SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ets'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_A_ADNA501_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 5ets 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE
(Staphylococcus
aureus) 		4 / 4 PHE B 123
ASN B  56
PHE B  54
ASN B  53
 5RX  B 202 (-3.3A)
5RX  B 202 (-3.2A)
5RX  B 202 (-3.4A)
None
 1.35A 2zbuA-5etsB:
0.0		 2zbuA-5etsB:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_C_ADNC503_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 5ets 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE
(Staphylococcus
aureus) 		4 / 4 PHE B 123
ASN B  56
PHE B  54
ASN B  53
 5RX  B 202 (-3.3A)
5RX  B 202 (-3.2A)
5RX  B 202 (-3.4A)
None
 1.39A 2zbuC-5etsB:
0.0		 2zbuC-5etsB:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5ets 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE
(Staphylococcus
aureus) 		5 / 10 GLN B  69
ILE B   2
LEU B   6
VAL B  96
LEU B  26
 None
 1.05A 3gwxA-5etsB:
undetectable		 3gwxA-5etsB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ets 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE
(Staphylococcus
aureus) 		3 / 3 GLN B  62
THR B  63
LEU B  99
 None
 0.72A 3ondA-5etsB:
undetectable		 3ondA-5etsB:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ets 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE
(Staphylococcus
aureus) 		3 / 3 GLN B  62
THR B  63
LEU B  99
 None
 0.71A 3ondB-5etsB:
undetectable		 3ondB-5etsB:
17.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 5ets 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE
(Staphylococcus
aureus) 		5 / 8 GLY B   9
THR B  43
ASN B  56
ARG B  92
PHE B 123
 5RX  B 202 ( 4.4A)
5RX  B 202 (-3.8A)
5RX  B 202 (-3.2A)
APC  B 201 ( 3.1A)
5RX  B 202 (-3.3A)
 0.45A 4m5mA-5etsB:
26.4		 4m5mA-5etsB:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5ets 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE
(Staphylococcus
aureus) 		4 / 7 ASN B  11
ASP B  97
GLY B   7
ASN B  56
 5RX  B 202 (-3.8A)
MG  B 204 (-2.5A)
None
5RX  B 202 (-3.2A)
 1.06A 5x7pA-5etsB:
undetectable		 5x7pA-5etsB:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5ets 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE
(Staphylococcus
aureus) 		4 / 7 VAL B 144
VAL B 135
ILE B 131
ASP B 130
 None
 0.84A 5yf9B-5etsB:
undetectable		 5yf9B-5etsB:
20.25