SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eue'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		5 / 12 ALA A 207
LEU A 172
ALA A 243
VAL A 241
ALA A 194
 None
 1.12A 1sa1A-5eueA:
undetectable
1sa1B-5eueA:
undetectable		 1sa1A-5eueA:
21.85
1sa1B-5eueA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		5 / 12 ALA A 207
LEU A 172
ALA A 243
VAL A 241
ALA A 194
 None
 1.10A 1sa1C-5eueA:
undetectable
1sa1D-5eueA:
undetectable		 1sa1C-5eueA:
21.85
1sa1D-5eueA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		4 / 6 LEU A 444
MET A 424
MET A 421
LEU A 461
 None
 1.20A 2oz7A-5eueA:
undetectable		 2oz7A-5eueA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		4 / 8 THR A 218
PRO A 219
GLU A 233
ALA A 229
 None
 1.05A 2v41G-5eueA:
undetectable
2v41H-5eueA:
undetectable		 2v41G-5eueA:
18.85
2v41H-5eueA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		3 / 3 GLU A 372
LEU A 375
ASP A 376
 None
 0.28A 3ko0A-5eueA:
undetectable		 3ko0A-5eueA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		3 / 3 GLU A 372
LEU A 375
ASP A 376
 None
 0.22A 3ko0T-5eueA:
undetectable		 3ko0T-5eueA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		5 / 12 TYR A 312
HIS A 448
ALA A 385
LEU A 382
LEU A 282
 LLP  A 311 ( 4.8A)
None
None
None
None
 1.13A 3ozwB-5eueA:
2.2		 3ozwB-5eueA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		5 / 10 LEU A 323
PHE A 295
PHE A 297
GLY A 152
PHE A 280
 None
 1.40A 3qpsA-5eueA:
undetectable		 3qpsA-5eueA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		4 / 6 GLY A 102
VAL A 407
HIS A 441
SER A 101
 PO4  A 602 ( 3.8A)
None
None
None
 1.13A 3tj7A-5eueA:
undetectable
3tj7B-5eueA:
undetectable		 3tj7A-5eueA:
16.67
3tj7B-5eueA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		4 / 6 GLY A 102
VAL A 407
HIS A 441
SER A 101
 PO4  A 602 ( 3.8A)
None
None
None
 1.09A 3tj7C-5eueA:
undetectable
3tj7D-5eueA:
undetectable		 3tj7C-5eueA:
16.67
3tj7D-5eueA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		4 / 6 VAL A 407
HIS A 441
SER A 101
GLY A 102
 None
None
None
PO4  A 602 ( 3.8A)
 1.06A 3tj7C-5eueA:
undetectable
3tj7D-5eueA:
undetectable		 3tj7C-5eueA:
16.67
3tj7D-5eueA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		4 / 5 LEU A 215
PHE A 204
PRO A 197
ALA A 200
 None
 1.49A 3vm4A-5eueA:
undetectable		 3vm4A-5eueA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		4 / 6 ALA A 226
GLY A 248
PRO A 247
VAL A 253
 None
LLP  A 311 ( 4.7A)
None
None
 0.92A 4dubA-5eueA:
undetectable		 4dubA-5eueA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		4 / 5 HIS A 441
TYR A 105
GLY A 102
SER A 101
 None
LLP  A 311 (-3.9A)
PO4  A 602 ( 3.8A)
None
 1.20A 4fu8A-5eueA:
undetectable		 4fu8A-5eueA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		5 / 12 ASN A 432
GLY A 248
GLY A 252
ILE A 281
GLY A 279
 None
LLP  A 311 ( 4.7A)
None
None
None
 0.99A 4obwB-5eueA:
2.8		 4obwB-5eueA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		5 / 12 ALA A 148
THR A 147
LEU A 323
GLY A 158
ALA A 156
 None
 1.17A 4ypmA-5eueA:
undetectable		 4ypmA-5eueA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		4 / 5 HIS A 441
SER A 101
GLY A 102
TYR A 105
 None
None
PO4  A 602 ( 3.8A)
LLP  A 311 (-3.9A)
 1.44A 5yodH-5eueA:
undetectable		 5yodH-5eueA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		4 / 7 ALA A 362
THR A 361
VAL A 143
TRP A 363
 None
 0.81A 6cduA-5eueA:
undetectable
6cduE-5eueA:
undetectable		 6cduA-5eueA:
18.87
6cduE-5eueA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		4 / 6 VAL A 143
TRP A 363
ALA A 362
THR A 361
 None
 0.78A 6cduB-5eueA:
undetectable
6cduC-5eueA:
undetectable		 6cduB-5eueA:
18.87
6cduC-5eueA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		4 / 7 VAL A 143
TRP A 363
ALA A 362
THR A 361
 None
 0.83A 6cduH-5eueA:
undetectable
6cduI-5eueA:
undetectable		 6cduH-5eueA:
18.87
6cduI-5eueA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		5 / 11 VAL A 164
SER A 320
THR A 319
VAL A 160
ALA A 362
 None
 1.28A 6dryA-5eueA:
undetectable		 6dryA-5eueA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		4 / 6 GLU A 140
TRP A 363
ALA A 360
GLN A 122
 None
 1.41A 6f6jC-5eueA:
undetectable
6f6jD-5eueA:
undetectable		 6f6jC-5eueA:
22.35
6f6jD-5eueA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		4 / 5 GLN A 333
THR A 349
THR A 309
GLY A 162
 None
 1.21A 6gbnC-5eueA:
2.5		 6gbnC-5eueA:
22.55