SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eui'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FM6_X_BRLX504_1 (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA)	5eui	HBB PROTEIN (Ochotona princeps)	5 / 12	PHE B 71 GLY B 74 HIS B 92 LEU B 106 LEU B 141	HEM B 201 (-4.3A) None HEM B 201 (-3.3A) HEM B 201 (-4.0A) HEM B 201 (-4.9A)	1.20A	1fm6X-5euiB: undetectable	1fm6X-5euiB: 20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GSE_A_EAAA224_1 (GLUTATHIONE TRANSFERASE)	5eui	HBB PROTEIN (Ochotona princeps)	5 / 12	GLY B 74 LEU B 78 LEU B 3 VAL B 1 ALA B 140	None	1.22A	1gseA-5euiB: undetectable	1gseA-5euiB: 20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LH6_A_NIOA155_1 (LEGHEMOGLOBIN A (NICOTINATE MET))	5eui	HBB PROTEIN (Ochotona princeps)	4 / 7	PHE B 42 PHE B 45 VAL B 67 HIS B 92	HEM B 201 (-4.0A) None HEM B 201 ( 4.0A) HEM B 201 (-3.3A)	0.81A	1lh6A-5euiB: 14.1	1lh6A-5euiB: 22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2TSR_D_D16D609_1 (THYMIDYLATE SYNTHASE)	5eui	HBB PROTEIN (Ochotona princeps)	5 / 9	ASP B 47 LEU B 48 GLY B 46 PHE B 45 THR B 38	None None None None HEM B 201 (-4.1A)	1.44A	2tsrD-5euiB: undetectable	2tsrD-5euiB: 17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WZD_A_LEVA1201_2 (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2)	5eui	HBB PROTEIN (Ochotona princeps)	4 / 5	LYS B 8 VAL B 1 LEU B 81 ASP B 79	None	1.06A	3wzdA-5euiB: undetectable	3wzdA-5euiB: 19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NOO_C_D16C402_1 (THYMIDYLATE SYNTHASE)	5eui	HBB PROTEIN (Ochotona princeps)	4 / 6	ASP B 47 LEU B 48 GLY B 46 PHE B 45	None	1.04A	5nooC-5euiB: undetectable	5nooC-5euiB: 21.80

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FM6_X_BRLX504_1","PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA","5eui","HBB PROTEIN","Ochotona princeps",5,"PHE B  71;GLY B  74;HIS B  92;LEU B 106;LEU B 141","HEM B 201 (-4.3A);None;HEM B 201 (-3.3A);HEM B 201 (-4.0A);HEM B 201 (-4.9A)","1.20A","1fm6X-5euiB:undetectable","1fm6X-5euiB:20.82"],["1GSE_A_EAAA224_1","GLUTATHIONE TRANSFERASE","5eui","HBB PROTEIN","Ochotona princeps",5,"GLY B  74;LEU B  78;LEU B   3;VAL B   1;ALA B 140","None","1.22A","1gseA-5euiB:undetectable","1gseA-5euiB:20.98"],["1LH6_A_NIOA155_1","LEGHEMOGLOBIN A (NICOTINATE MET)","5eui","HBB PROTEIN","Ochotona princeps",4,"PHE B  42;PHE B  45;VAL B  67;HIS B  92","HEM B 201 (-4.0A);None;HEM B 201 ( 4.0A);HEM B 201 (-3.3A)","0.81A","1lh6A-5euiB:14.1","1lh6A-5euiB:22.58"],["2TSR_D_D16D609_1","THYMIDYLATE SYNTHASE","5eui","HBB PROTEIN","Ochotona princeps",5,"ASP B  47;LEU B  48;GLY B  46;PHE B  45;THR B  38","None;None;None;None;HEM B 201 (-4.1A)","1.44A","2tsrD-5euiB:undetectable","2tsrD-5euiB:17.88"],["3WZD_A_LEVA1201_2","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","5eui","HBB PROTEIN","Ochotona princeps",4,"LYS B   8;VAL B   1;LEU B  81;ASP B  79","None","1.06A","3wzdA-5euiB:undetectable","3wzdA-5euiB:19.03"],["5NOO_C_D16C402_1","THYMIDYLATE SYNTHASE","5eui","HBB PROTEIN","Ochotona princeps",4,"ASP B  47;LEU B  48;GLY B  46;PHE B  45","None","1.04A","5nooC-5euiB:undetectable","5nooC-5euiB:21.80"]]