SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eum'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5eum LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA
(Haemophilus
influenzae) 		4 / 8 ALA A 512
GLY A 489
THR A 518
ILE A 524
 None
 0.64A 1gtnI-5eumA:
undetectable
1gtnJ-5eumA:
undetectable		 1gtnI-5eumA:
15.66
1gtnJ-5eumA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5eum LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA
(Haemophilus
influenzae) 		5 / 10 LEU A 465
ALA A 464
ILE A 468
ALA A 443
PHE A 475
 None
 1.16A 1xp0A-5eumA:
undetectable		 1xp0A-5eumA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5eum LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA
(Haemophilus
influenzae) 		5 / 12 ILE A 553
ALA A 550
LEU A 571
HIS A 581
PHE A 585
 None
 1.45A 1y0xX-5eumA:
undetectable		 1y0xX-5eumA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5eum LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA
(Haemophilus
influenzae) 		3 / 3 LEU A 571
HIS A 581
LYS A 578
 None
 1.07A 1y7iA-5eumA:
undetectable		 1y7iA-5eumA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5eum LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA
(Haemophilus
influenzae) 		5 / 12 ILE A 455
ALA A 458
ALA A 459
ILE A 438
LEU A 501
 None
 0.93A 2aclG-5eumA:
undetectable		 2aclG-5eumA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5eum LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA
(Haemophilus
influenzae) 		4 / 7 ILE A 412
LEU A 407
VAL A 506
ARG A 421
 None
 0.79A 2wd9A-5eumA:
undetectable		 2wd9A-5eumA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5eum LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA
(Haemophilus
influenzae) 		4 / 8 ILE A 412
LEU A 407
VAL A 506
ARG A 421
 None
 0.77A 2wd9B-5eumA:
undetectable		 2wd9B-5eumA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 5eum LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA
(Haemophilus
influenzae) 		5 / 9 LEU A 544
ALA A 541
ILE A 553
GLY A 381
ILE A 547
 MLI  A 609 (-3.9A)
None
None
None
None
 0.91A 3nu4B-5eumA:
undetectable		 3nu4B-5eumA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5eum LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA
(Haemophilus
influenzae) 		4 / 7 PHE A 467
GLU A 469
ARG A 493
ILE A 438
 None
None
MLI  A 608 (-3.3A)
None
 1.48A 4cx7C-5eumA:
undetectable
4cx7D-5eumA:
undetectable		 4cx7C-5eumA:
21.17
4cx7D-5eumA:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EUM_B_ACTB603_0
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 5eum LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA
(Haemophilus
influenzae) 		4 / 4 ALA A 439
ASN A 440
ARG A 452
ILE A 455
 None
 0.03A 5eumB-5eumA:
42.7		 5eumB-5eumA:
100.00