SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5evi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 GLN B 119
TYR B 221
VAL B 211
GLY B 214
 None
 1.15A 1ekjC-5eviB:
undetectable
1ekjD-5eviB:
undetectable		 1ekjC-5eviB:
21.35
1ekjD-5eviB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 VAL B 211
GLY B 214
GLN B 119
TYR B 221
 None
 1.22A 1ekjC-5eviB:
undetectable
1ekjD-5eviB:
undetectable		 1ekjC-5eviB:
21.35
1ekjD-5eviB:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE
(Pseudomonas
syringae
group
genomosp.
3) 		6 / 10 GLN B 119
TYR B 149
ASN B 151
TYR B 221
LYS B 313
GLY B 315
 None
 0.67A 1kvlA-5eviB:
54.5		 1kvlA-5eviB:
41.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE
(Pseudomonas
syringae
group
genomosp.
3) 		6 / 10 GLN B 119
TYR B 149
ASN B 151
TYR B 221
THR B 314
GLY B 315
 None
 0.35A 1kvlA-5eviB:
54.5		 1kvlA-5eviB:
41.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE
(Pseudomonas
syringae
group
genomosp.
3) 		6 / 10 GLY B  62
GLN B 119
ASN B 151
TYR B 221
THR B 314
GLY B 315
 None
 1.22A 1kvlA-5eviB:
54.5		 1kvlA-5eviB:
41.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 PHE B 116
LEU B 108
LEU B 216
LEU B 130
MET B 131
 None
 1.35A 1p33A-5eviB:
undetectable		 1p33A-5eviB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 11 ALA B 220
ILE B 154
PHE B 134
LEU B 100
ILE B 160
 None
 1.24A 2h42A-5eviB:
undetectable		 2h42A-5eviB:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 PHE B  39
ILE B 231
GLY B  35
ILE B 238
 EDO  B 401 ( 4.6A)
None
MLY  B  36 ( 2.4A)
None
 0.95A 2qwxA-5eviB:
undetectable
2qwxB-5eviB:
undetectable		 2qwxA-5eviB:
21.20
2qwxB-5eviB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 PHE B 134
PHE B 116
ILE B 103
GLY B 158
 None
 0.89A 2v0mC-5eviB:
undetectable		 2v0mC-5eviB:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE
(Pseudomonas
syringae
group
genomosp.
3) 		6 / 12 SER B  63
LYS B  66
ASN B 151
GLY B 315
THR B 317
ARG B 347
 None
 0.99A 3mzeA-5eviB:
7.0		 3mzeA-5eviB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE
(Pseudomonas
syringae
group
genomosp.
3) 		6 / 12 SER B  63
LYS B  66
ASN B 151
THR B 314
GLY B 315
THR B 317
 None
 0.72A 3mzeA-5eviB:
7.0		 3mzeA-5eviB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 TYR B 149
HIS B 111
ARG B 147
 None
 1.17A 4e7bC-5eviB:
undetectable		 4e7bC-5eviB:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 ALA B 338
GLY B 321
SER B 316
GLY B  26
ASN B  22
 MLY  B 340 ( 4.0A)
MLY  B 340 ( 3.1A)
None
None
None
 1.08A 4obwA-5eviB:
undetectable		 4obwA-5eviB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 PHE B  39
ILE B 231
GLY B  35
ILE B 238
 EDO  B 401 ( 4.6A)
None
MLY  B  36 ( 2.4A)
None
 0.85A 4qogA-5eviB:
undetectable
4qogB-5eviB:
undetectable		 4qogA-5eviB:
21.20
4qogB-5eviB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 ILE B 238
THR B  67
ARG B 255
LEU B  61
LEU B 230
 None
None
None
MLY  B 224 ( 4.9A)
None
 1.38A 4qynB-5eviB:
1.0		 4qynB-5eviB:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 LEU B 350
GLU B 346
ASN B  22
ILE B  24
 MLY  B 349 ( 4.6A)
MLY  B 349 ( 4.5A)
None
MLY  B 340 ( 4.7A)
 0.94A 4ww7A-5eviB:
undetectable		 4ww7A-5eviB:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 4 LEU B 130
LEU B 156
GLY B 155
GLU B 219
 None
 1.11A 5hhjA-5eviB:
undetectable		 5hhjA-5eviB:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 9 ILE B  29
ALA B  30
ILE B  31
ALA B 351
LEU B 355
 None
 1.05A 5mvmA-5eviB:
undetectable
5mvmE-5eviB:
undetectable		 5mvmA-5eviB:
13.78
5mvmE-5eviB:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 ARG B 255
VAL B 324
PHE B 326
GLU B 235
 None
 1.49A 5vuyA-5eviB:
undetectable
5vuyB-5eviB:
undetectable		 5vuyA-5eviB:
22.35
5vuyB-5eviB:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 5 LEU B 282
ILE B 118
MET B 264
GLY B 263
 None
 1.08A 6hd6A-5eviB:
undetectable		 6hd6A-5eviB:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 PRO B 121
VAL B 124
TYR B 221
ILE B 215
PHE B 134
 None
 1.15A 6j20A-5eviB:
undetectable		 6j20A-5eviB:
21.19