SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5evl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		4 / 6 VAL A 337
VAL A  55
ASN A  43
ILE A  17
 None
 0.97A 1e06A-5evlA:
1.2		 1e06A-5evlA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		5 / 10 GLY A 286
LEU A 284
VAL A 350
ALA A 292
ASN A 289
 None
None
None
None
SO4  A 402 (-2.9A)
 1.35A 1fpqA-5evlA:
undetectable		 1fpqA-5evlA:
20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		5 / 10 GLY A  64
ASN A 153
TYR A 223
THR A 316
GLY A 317
 None
None
None
SO4  A 403 (-4.0A)
SO4  A 403 (-3.5A)
 1.31A 1kvlA-5evlA:
53.6		 1kvlA-5evlA:
47.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		5 / 10 LEU A 120
GLN A 121
TYR A 151
THR A 316
GLY A 317
 None
None
SO4  A 403 (-4.8A)
SO4  A 403 (-4.0A)
SO4  A 403 (-3.5A)
 0.84A 1kvlA-5evlA:
53.6		 1kvlA-5evlA:
47.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		7 / 10 LEU A 120
TYR A 151
ASN A 153
TYR A 223
LYS A 315
THR A 316
GLY A 317
 None
SO4  A 403 (-4.8A)
None
None
SO4  A 403 (-3.2A)
SO4  A 403 (-4.0A)
SO4  A 403 (-3.5A)
 0.40A 1kvlA-5evlA:
53.6		 1kvlA-5evlA:
47.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		4 / 8 ASP A 172
GLY A 160
SER A  67
ASP A 219
 None
 0.83A 1m4iA-5evlA:
undetectable		 1m4iA-5evlA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		5 / 9 ALA A 251
LEU A 248
TYR A 235
LEU A 179
HIS A 256
 None
 1.19A 1y7iA-5evlA:
undetectable		 1y7iA-5evlA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		5 / 10 ALA A 251
LEU A 248
TYR A 235
LEU A 179
HIS A 256
 None
 1.17A 1y7iB-5evlA:
undetectable		 1y7iB-5evlA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		5 / 12 ALA A 222
GLY A 224
MET A 175
LEU A 180
LEU A 183
 None
 0.96A 2hw2A-5evlA:
undetectable		 2hw2A-5evlA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		5 / 10 LEU A 158
GLY A 160
LEU A 162
LEU A 107
ALA A  90
 None
 0.97A 2v3kA-5evlA:
undetectable		 2v3kA-5evlA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		5 / 12 LYS A  68
ASN A 153
LYS A 315
THR A 316
GLY A 317
 None
None
SO4  A 403 (-3.2A)
SO4  A 403 (-4.0A)
SO4  A 403 (-3.5A)
 0.54A 3huoA-5evlA:
16.0		 3huoA-5evlA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		5 / 10 GLY A 224
GLU A 176
MET A 175
LEU A  63
ILE A  66
 None
 1.30A 3kvrA-5evlA:
undetectable		 3kvrA-5evlA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		6 / 12 SER A  65
LYS A  68
ASN A 153
GLY A 317
THR A 319
ARG A 349
 SO4  A 403 (-2.6A)
None
None
SO4  A 403 (-3.5A)
None
SO4  A 403 ( 4.8A)
 1.00A 3mzeA-5evlA:
7.0		 3mzeA-5evlA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		6 / 12 SER A  65
LYS A  68
ASN A 153
THR A 316
GLY A 317
THR A 319
 SO4  A 403 (-2.6A)
None
None
SO4  A 403 (-4.0A)
SO4  A 403 (-3.5A)
None
 0.68A 3mzeA-5evlA:
7.0		 3mzeA-5evlA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		3 / 3 LEU A 364
ARG A 351
ASN A 314
 None
 0.78A 3qxvD-5evlA:
undetectable		 3qxvD-5evlA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		5 / 12 GLY A  52
GLY A  28
ALA A  47
THR A  56
ASP A  58
 None
 0.97A 3sugA-5evlA:
undetectable		 3sugA-5evlA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		5 / 9 LEU A  86
ALA A 163
GLY A 157
ILE A 156
LEU A 108
 None
 1.03A 3u7sA-5evlA:
undetectable		 3u7sA-5evlA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		4 / 7 GLU A 176
ILE A 190
VAL A 337
PHE A  70
 None
 1.01A 4a97H-5evlA:
undetectable		 4a97H-5evlA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ID5_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		5 / 12 LEU A 110
VAL A 101
TYR A 136
PRO A 141
PRO A 145
 None
 1.32A 4id5A-5evlA:
0.4		 4id5A-5evlA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFV_A_T27A601_1
(EXORIBONUCLEASE H,
P66 RT)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		5 / 12 LEU A 110
VAL A 101
TYR A 136
PRO A 141
PRO A 145
 None
 1.30A 4ifvA-5evlA:
0.2		 4ifvA-5evlA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFY_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		5 / 12 LEU A 110
VAL A 101
TYR A 136
PRO A 141
PRO A 145
 None
 1.29A 4ifyA-5evlA:
0.3		 4ifyA-5evlA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG3_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		5 / 12 LEU A 110
VAL A 101
TYR A 136
PRO A 141
PRO A 145
 None
 1.31A 4ig3A-5evlA:
0.7		 4ig3A-5evlA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFB_A_T27A607_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H,
EXORIBONUCLEA P66 RT)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		5 / 12 LEU A 110
VAL A 101
TYR A 136
PRO A 141
PRO A 145
 None
 1.35A 4kfbA-5evlA:
undetectable		 4kfbA-5evlA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		5 / 9 ALA A  90
TYR A  93
GLY A  75
PHE A 159
SER A 166
 None
 1.42A 4mmeA-5evlA:
0.5		 4mmeA-5evlA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		5 / 12 TYR A 235
LEU A 183
GLY A  76
ALA A 251
SER A 255
 None
 1.04A 4rrxA-5evlA:
undetectable		 4rrxA-5evlA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		5 / 12 TYR A 235
LEU A 183
GLY A  76
ALA A 251
SER A 255
 None
 1.05A 4rrxB-5evlA:
undetectable		 4rrxB-5evlA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		5 / 12 LEU A 183
LEU A 269
LEU A 179
ALA A  80
LEU A  84
 None
 1.08A 5ienB-5evlA:
undetectable		 5ienB-5evlA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		5 / 12 LEU A 327
VAL A 360
VAL A 334
GLY A 335
ILE A 336
 None
 0.79A 5j2tC-5evlA:
undetectable		 5j2tC-5evlA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		4 / 7 LEU A 120
LYS A 315
ILE A  66
THR A 316
 None
SO4  A 403 (-3.2A)
None
SO4  A 403 (-4.0A)
 1.41A 5ljcA-5evlA:
1.0		 5ljcA-5evlA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		5 / 12 LEU A 110
LEU A 162
ALA A  90
SER A 100
TYR A 135
 None
 1.10A 5ljeA-5evlA:
undetectable		 5ljeA-5evlA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		4 / 8 GLY A 157
GLU A 221
ALA A 220
PHE A 122
 None
SO4  A 401 (-2.9A)
None
None
 0.95A 5mvsB-5evlA:
undetectable		 5mvsB-5evlA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5evl BETA-LACTAMASE
(Chromobacterium
violaceum) 		5 / 11 VAL A 337
ALA A  32
LEU A  63
THR A  59
ALA A  30
 None
 1.31A 6dk1C-5evlA:
undetectable		 6dk1C-5evlA:
21.05