SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5evo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5evo DEHYDROASCORBATE
REDUCTASE
(Cenchrus
americanus) 		5 / 12 HIS A 134
THR A  92
SER A 148
LEU A 131
VAL A 180
 None
 1.38A 3u9fJ-5evoA:
undetectable
3u9fL-5evoA:
undetectable		 3u9fJ-5evoA:
22.18
3u9fL-5evoA:
22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5D9W_A_ASCA301_0
(DEHYDROASCORBATE
REDUCTASE)		 5evo DEHYDROASCORBATE
REDUCTASE
(Cenchrus
americanus) 		8 / 9 LYS A   8
ASP A  19
PRO A  21
PHE A 104
HIS A 160
GLY A 206
TRP A 207
LYS A 210
 GOL  A 302 (-2.9A)
GOL  A 302 (-3.0A)
GOL  A 302 (-4.8A)
None
None
GOL  A 302 (-3.6A)
GOL  A 302 (-3.8A)
GOL  A 302 (-3.3A)
 0.46A 5d9wA-5evoA:
24.0		 5d9wA-5evoA:
77.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5evo DEHYDROASCORBATE
REDUCTASE
(Cenchrus
americanus) 		3 / 3 GLY A  18
VAL A   5
MET A  39
 None
 0.61A 5ycpA-5evoA:
undetectable		 5ycpA-5evoA:
16.11