SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5evy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		3 / 3 TRP X  85
HIS X 224
MET X 217
 None
 0.83A 1l5qB-5evyX:
undetectable		 1l5qB-5evyX:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 12 GLY X 326
GLN X 327
ARG X 363
ILE X  63
PHE X 112
 None
 1.40A 1p93D-5evyX:
undetectable		 1p93D-5evyX:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 12 LEU X 329
ALA X 336
LEU X  24
VAL X  10
ILE X  58
 None
 0.99A 1s9pD-5evyX:
undetectable		 1s9pD-5evyX:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_C_RBTC8001_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN
RNA POLYMERASE SIGMA
FACTOR RPOD)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 11 GLN X 327
GLN X 368
ASP X 297
ARG X 372
SER X 371
 None
 1.43A 2a68C-5evyX:
0.0
2a68F-5evyX:
0.0		 2a68C-5evyX:
18.33
2a68F-5evyX:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A69_C_RPTC8001_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN
RNA POLYMERASE SIGMA
FACTOR RPOD)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 11 GLN X 327
GLN X 368
ASP X 297
ARG X 372
SER X 371
 None
 1.42A 2a69C-5evyX:
0.0
2a69F-5evyX:
1.7		 2a69C-5evyX:
18.33
2a69F-5evyX:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		3 / 3 ASP X 348
ASP X 154
ASN X 341
 None
 0.85A 2bm9D-5evyX:
undetectable		 2bm9D-5evyX:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 11 HIS X  87
ALA X  88
MET X 217
VAL X  94
GLY X 223
 None
 1.08A 2uxpB-5evyX:
undetectable		 2uxpB-5evyX:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 12 TYR X 134
PHE X 296
LEU X 299
ALA X 158
SER X 165
 None
 1.48A 3apvB-5evyX:
undetectable		 3apvB-5evyX:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 12 GLY X 191
SER X 284
LEU X 268
LEU X 198
TYR X 202
 None
 1.09A 3cs8A-5evyX:
undetectable		 3cs8A-5evyX:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 12 LEU X 353
LEU X 339
VAL X   8
ILE X 310
LEU X  20
 None
 1.16A 3datA-5evyX:
undetectable		 3datA-5evyX:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 12 LEU X 353
LEU X 339
VAL X   8
ILE X 310
LEU X  20
 None
 1.09A 3fl9B-5evyX:
undetectable		 3fl9B-5evyX:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 10 LEU X 353
LEU X 339
VAL X   8
ILE X 310
LEU X  20
 None
 1.04A 3fl9E-5evyX:
undetectable		 3fl9E-5evyX:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		4 / 6 MET X 115
LEU X  24
ILE X 107
ILE X  58
 None
 0.93A 3gcsA-5evyX:
undetectable		 3gcsA-5evyX:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 12 GLY X 326
GLN X 327
ARG X 363
ILE X  63
PHE X 112
 None
 1.43A 3mneA-5evyX:
undetectable		 3mneA-5evyX:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 12 ALA X  16
GLY X 328
ALA X 308
TYR X 356
LEU X  34
 FAD  X 501 (-2.8A)
None
None
None
None
 1.18A 3qxyA-5evyX:
undetectable		 3qxyA-5evyX:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 11 ALA X  16
GLY X 328
ALA X 308
TYR X 356
LEU X  34
 FAD  X 501 (-2.8A)
None
None
None
None
 1.18A 3rc0A-5evyX:
undetectable		 3rc0A-5evyX:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 9 LEU X 212
VAL X 230
GLY X 191
ILE X 285
THR X 195
 None
 1.14A 3spkA-5evyX:
undetectable		 3spkA-5evyX:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 9 LEU X 198
THR X 195
VAL X 193
THR X 227
ILE X 238
 None
 1.14A 3tbgD-5evyX:
undetectable		 3tbgD-5evyX:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		4 / 6 ILE X 220
TRP X  82
ILE X  81
TRP X  85
 None
 1.39A 3weoA-5evyX:
undetectable		 3weoA-5evyX:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		3 / 3 ARG X 167
PHE X 296
PRO X 298
 None
 0.87A 3zoaB-5evyX:
undetectable		 3zoaB-5evyX:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		4 / 6 GLY X 324
GLY X 326
ASN X  53
ILE X  15
 FAD  X 501 (-3.5A)
None
None
FAD  X 501 ( 4.2A)
 0.96A 4fglD-5evyX:
3.1		 4fglD-5evyX:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 12 GLY X 223
LEU X 219
SER X 243
ALA X 240
ARG X 260
 None
 1.02A 4qtuB-5evyX:
undetectable		 4qtuB-5evyX:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 12 VAL X 367
VAL X 303
GLU X 411
ILE X 310
HIS X 315
 None
 1.41A 4s0vA-5evyX:
3.5		 4s0vA-5evyX:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 12 GLY X 326
GLN X 327
ARG X 363
ILE X  63
PHE X 112
 None
 1.47A 4udcA-5evyX:
undetectable		 4udcA-5evyX:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 9 GLN X 368
GLY X 328
GLU X 330
ILE X 310
ALA X 159
 None
None
None
None
FAD  X 501 (-4.7A)
 1.35A 5entC-5evyX:
1.5		 5entC-5evyX:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 12 VAL X 141
GLU X 136
LEU X  24
ALA X 156
LEU X 353
 None
 1.39A 5nd2B-5evyX:
undetectable		 5nd2B-5evyX:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 12 ALA X 336
GLU X 345
ILE X 349
ARG X 306
VAL X   8
 None
 1.00A 5vlmE-5evyX:
1.8		 5vlmE-5evyX:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 12 GLU X 345
LEU X 352
ILE X 349
ARG X 306
VAL X   8
 None
 1.05A 5vlmE-5evyX:
1.8		 5vlmE-5evyX:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		4 / 5 TYR X 356
ARG X 360
MET X 335
LEU X  20
 None
 1.17A 5x19J-5evyX:
undetectable		 5x19J-5evyX:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		4 / 5 TYR X 356
ARG X 360
MET X 335
LEU X  20
 None
 1.17A 5x1bJ-5evyX:
undetectable		 5x1bJ-5evyX:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 11 ASP X 331
TYR X 356
VAL X 303
GLY X 305
VAL X 155
 None
 1.43A 6hu9A-5evyX:
1.9
6hu9E-5evyX:
undetectable
6hu9I-5evyX:
undetectable		 6hu9A-5evyX:
21.19
6hu9E-5evyX:
19.24
6hu9I-5evyX:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 10 ASP X 331
TYR X 356
VAL X 303
GLY X 305
VAL X 155
 None
 1.42A 6hu9L-5evyX:
undetectable
6hu9P-5evyX:
undetectable
6hu9T-5evyX:
undetectable		 6hu9L-5evyX:
21.19
6hu9P-5evyX:
19.24
6hu9T-5evyX:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 5evy SALICYLATE
HYDROXYLASE
(Pseudomonas
putida) 		5 / 12 ILE X  11
GLY X  12
GLY X  14
ALA X  19
VAL X 131
 None
FAD  X 501 ( 4.0A)
FAD  X 501 (-3.7A)
None
None
 0.86A 6iftA-5evyX:
undetectable		 6iftA-5evyX:
22.10