SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ew5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 5ew5 COLICIN-E9
(Escherichia
coli) 		4 / 8 VAL A 199
SER A 198
ASN A 196
ASP A 188
 None
 1.24A 1hwiB-5ew5A:
undetectable		 1hwiB-5ew5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 5ew5 COLICIN-E9
(Escherichia
coli) 		4 / 7 VAL A 199
SER A 198
ASN A 196
ASP A 188
 None
 1.09A 1hwiC-5ew5A:
undetectable		 1hwiC-5ew5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 5ew5 COLICIN-E9
(Escherichia
coli) 		4 / 7 VAL A 199
SER A 198
ASN A 196
ASP A 188
 None
 1.10A 1hwiD-5ew5A:
undetectable		 1hwiD-5ew5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 5ew5 COLICIN-E9
(Escherichia
coli) 		4 / 8 VAL A 199
SER A 198
ASN A 196
ASP A 188
 None
 1.23A 1hwkA-5ew5A:
undetectable		 1hwkA-5ew5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 5ew5 COLICIN-E9
(Escherichia
coli) 		4 / 8 VAL A 199
SER A 198
ASN A 196
ASP A 188
 None
 1.21A 1hwkC-5ew5A:
undetectable		 1hwkC-5ew5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 5ew5 COLICIN-E9
(Escherichia
coli) 		4 / 8 VAL A 199
SER A 198
ASN A 196
ASP A 188
 None
 1.21A 1hwkD-5ew5A:
undetectable		 1hwkD-5ew5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 5ew5 COLICIN-E9
(Escherichia
coli) 		4 / 6 ALA A 414
LYS A 417
ASP A 421
ALA A 422
 None
 0.44A 1iwhA-5ew5A:
undetectable		 1iwhA-5ew5A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 5ew5 COLICIN-E9
(Escherichia
coli) 		5 / 12 GLY A 219
ILE A 233
SER A 234
ALA A 212
SER A 279
 None
 1.09A 1ve3B-5ew5A:
undetectable		 1ve3B-5ew5A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 5ew5 COLICIN-E9
(Escherichia
coli) 		5 / 12 ALA A 474
PRO A 483
GLY A 467
ASP A 473
LEU A 471
 None
 1.09A 2nv4A-5ew5A:
undetectable		 2nv4A-5ew5A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 5ew5 COLICIN-E9
(Escherichia
coli) 		5 / 12 ALA A 474
PRO A 483
GLY A 467
ASP A 473
LEU A 471
 None
 1.12A 2nv4B-5ew5A:
undetectable		 2nv4B-5ew5A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5ew5 COLICIN-E9
(Escherichia
coli) 		4 / 8 SER A 198
ASN A 196
ILE A 197
ASP A 188
 None
 1.09A 2v57A-5ew5A:
undetectable		 2v57A-5ew5A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5ew5 COLICIN-E9
(Escherichia
coli) 		4 / 8 SER A 198
ASN A 196
ILE A 197
ASP A 188
 None
 1.09A 2v57C-5ew5A:
undetectable		 2v57C-5ew5A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5ew5 COLICIN-E9
(Escherichia
coli) 		5 / 12 ALA A 271
ILE A 225
LEU A 231
VAL A 105
ILE A 107
 None
 1.32A 3adsB-5ew5A:
undetectable		 3adsB-5ew5A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5ew5 COLICIN-E9
(Escherichia
coli) 		5 / 11 THR A 268
VAL A 288
ILE A 156
ASN A 196
ILE A 197
 None
 1.18A 3kpcA-5ew5A:
undetectable		 3kpcA-5ew5A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 5ew5 COLICIN-E9
(Escherichia
coli) 		5 / 12 GLY A 266
ARG A 185
PRO A  93
ASP A 189
LEU A 137
 None
 1.10A 3m6vA-5ew5A:
undetectable		 3m6vA-5ew5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 5ew5 COLICIN-E9
(Escherichia
coli) 		5 / 12 GLY A 266
ARG A 185
PRO A  93
ASP A 189
LEU A 137
 None
 1.10A 3m6vB-5ew5A:
undetectable		 3m6vB-5ew5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 5ew5 COLICIN-E9
(Escherichia
coli) 		4 / 6 ILE A 156
ASP A 164
GLY A  91
VAL A 200
 None
 0.94A 3n3iA-5ew5A:
undetectable		 3n3iA-5ew5A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 5ew5 COLICIN-E9
(Escherichia
coli) 		4 / 7 PHE A 275
VAL A 284
ILE A 273
SER A 106
 None
 0.77A 3pglA-5ew5A:
undetectable		 3pglA-5ew5A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 5ew5 COLICIN-E9
(Escherichia
coli) 		4 / 8 GLU A 336
ASP A 337
ARG A 432
ARG A 433
 None
 1.06A 4uhxA-5ew5A:
undetectable		 4uhxA-5ew5A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 5ew5 COLICIN-E9
(Escherichia
coli) 		5 / 12 ASN A 236
SER A 106
ARG A 217
PRO A 218
SER A 238
 None
 1.32A 4uroA-5ew5A:
undetectable		 4uroA-5ew5A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 5ew5 COLICIN-E9
(Escherichia
coli) 		5 / 12 ASN A 236
SER A 106
ARG A 217
PRO A 218
SER A 238
 None
 1.28A 4uroB-5ew5A:
undetectable		 4uroB-5ew5A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 5ew5 COLICIN-E9
(Escherichia
coli) 		5 / 12 ASN A 236
SER A 106
ARG A 217
PRO A 218
SER A 238
 None
 1.32A 4uroD-5ew5A:
undetectable		 4uroD-5ew5A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 5ew5 COLICIN-E9
(Escherichia
coli) 		3 / 3 ARG A 433
ASP A 337
ARG A 432
 None
 0.63A 4wq4B-5ew5A:
undetectable		 4wq4B-5ew5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 5ew5 COLICIN-E9
(Escherichia
coli) 		3 / 3 VAL A 317
PHE A 498
ARG A 502
 None
 0.95A 4xr4B-5ew5A:
undetectable		 4xr4B-5ew5A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5ew5 COLICIN-E9
(Escherichia
coli) 		3 / 3 ARG A 432
ASN A 341
ASP A 421
 None
 0.92A 5gwxA-5ew5A:
undetectable		 5gwxA-5ew5A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 5ew5 COLICIN-E9
(Escherichia
coli) 		5 / 12 VAL A 230
PRO A 229
PHE A 275
ILE A 273
ASN A 232
 None
 1.39A 5hgcA-5ew5A:
undetectable		 5hgcA-5ew5A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 5ew5 COLICIN-E9
(Escherichia
coli) 		3 / 3 PRO A 169
SER A 171
SER A 172
 None
 0.50A 6bpyA-5ew5A:
undetectable		 6bpyA-5ew5A:
20.42