SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ewn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		3 / 3 ALA A 376
VAL A 353
TRP A 351
 None
 0.97A 1av2A-5ewnA:
undetectable
1av2B-5ewnA:
undetectable		 1av2A-5ewnA:
6.37
1av2B-5ewnA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		3 / 3 ALA A 376
VAL A 369
TRP A 351
 None
 0.87A 1av2A-5ewnA:
undetectable
1av2B-5ewnA:
undetectable		 1av2A-5ewnA:
6.37
1av2B-5ewnA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		3 / 3 TRP A 351
ALA A 376
VAL A 369
 None
 0.90A 1av2C-5ewnA:
undetectable
1av2D-5ewnA:
undetectable		 1av2C-5ewnA:
6.37
1av2D-5ewnA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		3 / 3 ARG A 179
ILE A 102
TRP A 350
 None
 1.20A 1m8eB-5ewnA:
undetectable		 1m8eB-5ewnA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		5 / 11 THR A 319
SER A 320
PHE A 367
VAL A 326
PHE A 297
 None
 1.49A 1q23G-5ewnA:
undetectable		 1q23G-5ewnA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		3 / 3 ALA A 376
VAL A 353
TRP A 351
 None
 0.96A 1w5uA-5ewnA:
undetectable
1w5uB-5ewnA:
undetectable		 1w5uA-5ewnA:
6.37
1w5uB-5ewnA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		3 / 3 ALA A 376
VAL A 369
TRP A 351
 None
 0.87A 1w5uA-5ewnA:
undetectable
1w5uB-5ewnA:
undetectable		 1w5uA-5ewnA:
6.37
1w5uB-5ewnA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		3 / 3 TRP A 351
ALA A 376
VAL A 369
 None
 0.87A 1w5uA-5ewnA:
undetectable
1w5uB-5ewnA:
undetectable		 1w5uA-5ewnA:
6.37
1w5uB-5ewnA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD6_0
(GRAMICIDIN D)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		4 / 4 TRP A 351
TRP A 324
ALA A 376
VAL A 353
 None
 1.17A 1w5uC-5ewnA:
undetectable
1w5uD-5ewnA:
undetectable		 1w5uC-5ewnA:
6.37
1w5uD-5ewnA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		3 / 3 ALA A 376
VAL A 369
TRP A 351
 None
 0.90A 2izqA-5ewnA:
undetectable
2izqB-5ewnA:
undetectable		 2izqA-5ewnA:
6.37
2izqB-5ewnA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC6_0
(GRAMICIDIN D)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		4 / 4 ALA A 376
VAL A 353
TRP A 351
TRP A 324
 None
 1.22A 2izqC-5ewnA:
undetectable
2izqD-5ewnA:
undetectable		 2izqC-5ewnA:
6.37
2izqD-5ewnA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		3 / 3 TRP A 351
ALA A 376
VAL A 369
 None
 0.87A 2izqC-5ewnA:
undetectable
2izqD-5ewnA:
undetectable		 2izqC-5ewnA:
6.37
2izqD-5ewnA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		4 / 5 LEU A 112
GLN A 406
THR A 405
THR A 218
 None
 1.32A 2zj0C-5ewnA:
undetectable		 2zj0C-5ewnA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		4 / 4 LEU A 112
GLN A 406
THR A 405
THR A 218
 None
 1.31A 2zj0D-5ewnA:
undetectable		 2zj0D-5ewnA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		4 / 4 LEU A 244
GLN A 239
THR A 231
THR A  91
 None
 1.50A 2zj0D-5ewnA:
undetectable		 2zj0D-5ewnA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		4 / 5 LEU A 112
GLN A 406
THR A 405
THR A 218
 None
 1.36A 3ce6B-5ewnA:
undetectable		 3ce6B-5ewnA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		3 / 3 ARG A 179
ILE A 102
TRP A 350
 None
 1.15A 3e68A-5ewnA:
undetectable		 3e68A-5ewnA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		3 / 3 TRP A 351
ALA A 376
VAL A 369
 None
 0.97A 3l8lA-5ewnA:
undetectable
3l8lB-5ewnA:
undetectable		 3l8lA-5ewnA:
6.37
3l8lB-5ewnA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		3 / 3 TRP A 351
ALA A 376
VAL A 369
 None
 0.92A 3l8lC-5ewnA:
undetectable
3l8lD-5ewnA:
undetectable		 3l8lC-5ewnA:
6.37
3l8lD-5ewnA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		4 / 5 ASN A 214
ASP A 375
GLU A 316
SER A 216
 None
 1.45A 3p2kC-5ewnA:
undetectable		 3p2kC-5ewnA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		4 / 7 ARG A 365
VAL A 277
PHE A 367
GLU A 280
 None
 1.47A 4jseA-5ewnA:
undetectable
4jseB-5ewnA:
undetectable		 4jseA-5ewnA:
21.32
4jseB-5ewnA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		3 / 3 LYS A 195
PRO A 196
SER A 197
 None
 0.46A 4k50I-5ewnA:
undetectable		 4k50I-5ewnA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		5 / 12 LEU A 158
LEU A 144
HIS A 181
ARG A 159
ILE A 225
 None
 0.99A 4x1fA-5ewnA:
undetectable		 4x1fA-5ewnA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		3 / 3 ASN A 290
SER A 366
ARG A 317
 None
 0.90A 5b2qA-5ewnA:
undetectable		 5b2qA-5ewnA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 5ewn STRUCTURAL PROTEIN
(Mamastrovirus
1) 		3 / 3 ARG A 365
ARG A 317
ARG A 361
 None
 0.82A 5vcgA-5ewnA:
undetectable		 5vcgA-5ewnA:
22.54