SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ewp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5ewp ARO (ARMADILLO
REPEATS ONLY
PROTEIN)
(Plasmodium
falciparum) 		4 / 5 GLY A 166
ILE A 164
VAL A 130
SER A 162
 None
 1.14A 1rs7A-5ewpA:
undetectable		 1rs7A-5ewpA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5ewp ARO (ARMADILLO
REPEATS ONLY
PROTEIN)
(Plasmodium
falciparum) 		4 / 6 GLY A 166
ILE A 164
VAL A 130
SER A 162
 None
 1.10A 1rs7B-5ewpA:
undetectable		 1rs7B-5ewpA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 5ewp ARO (ARMADILLO
REPEATS ONLY
PROTEIN)
(Plasmodium
falciparum) 		4 / 7 LEU A  92
LEU A  89
ILE A  81
TYR A  46
 None
 1.13A 2hc4A-5ewpA:
undetectable		 2hc4A-5ewpA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 5ewp ARO (ARMADILLO
REPEATS ONLY
PROTEIN)
(Plasmodium
falciparum) 		5 / 12 ILE A  81
ALA A  83
LEU A 117
GLU A  53
ARG A  41
 None
 1.33A 3eigA-5ewpA:
undetectable		 3eigA-5ewpA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 5ewp ARO (ARMADILLO
REPEATS ONLY
PROTEIN)
(Plasmodium
falciparum) 		5 / 10 ASP A 226
LEU A 269
LYS A 243
VAL A 242
ILE A 195
 None
 1.33A 3kz7A-5ewpA:
undetectable		 3kz7A-5ewpA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5ewp ARO (ARMADILLO
REPEATS ONLY
PROTEIN)
(Plasmodium
falciparum) 		4 / 4 ASN A 200
SER A 266
LEU A 254
THR A 196
 None
 1.28A 4an2A-5ewpA:
undetectable		 4an2A-5ewpA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 5ewp ARO (ARMADILLO
REPEATS ONLY
PROTEIN)
(Plasmodium
falciparum) 		3 / 3 VAL A  51
TYR A 101
ALA A 104
 None
 0.42A 4ybnA-5ewpA:
undetectable		 4ybnA-5ewpA:
21.85