SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ewq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5ewq AMIDASE
(Bacillus
anthracis) 		4 / 6 VAL A 508
GLY A 509
LEU A 463
GLU A 458
 None
 1.00A 1fduD-5ewqA:
undetectable		 1fduD-5ewqA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 5ewq AMIDASE
(Bacillus
anthracis) 		4 / 8 GLN A 384
LEU A 283
LEU A 480
SER A 451
 None
 1.16A 1hk2A-5ewqA:
undetectable		 1hk2A-5ewqA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 5ewq AMIDASE
(Bacillus
anthracis) 		4 / 7 GLU A 489
GLU A 247
ILE A 252
LEU A 268
 None
 1.42A 1q0yH-5ewqA:
undetectable
1q0yL-5ewqA:
undetectable		 1q0yH-5ewqA:
16.63
1q0yL-5ewqA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 5ewq AMIDASE
(Bacillus
anthracis) 		4 / 7 LEU A 517
PHE A 518
GLY A 521
ILE A 358
 None
 0.81A 2bdmA-5ewqA:
undetectable		 2bdmA-5ewqA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5ewq AMIDASE
(Bacillus
anthracis) 		6 / 11 GLN A 258
ALA A 254
ALA A 189
GLY A 230
THR A 233
ALA A 232
 None
 1.34A 2f16H-5ewqA:
undetectable
2f16I-5ewqA:
undetectable		 2f16H-5ewqA:
19.11
2f16I-5ewqA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5ewq AMIDASE
(Bacillus
anthracis) 		6 / 11 GLN A 258
ALA A 254
ALA A 189
GLY A 230
THR A 233
ALA A 232
 None
 1.34A 2f16V-5ewqA:
undetectable
2f16W-5ewqA:
undetectable		 2f16V-5ewqA:
19.11
2f16W-5ewqA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 5ewq AMIDASE
(Bacillus
anthracis) 		4 / 5 ILE A 277
PRO A 278
PHE A 390
ILE A 412
 None
 0.87A 2hjhA-5ewqA:
undetectable		 2hjhA-5ewqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5ewq AMIDASE
(Bacillus
anthracis) 		3 / 3 ASN A 416
ARG A 423
ASP A 165
 None
 0.99A 2qe6A-5ewqA:
undetectable		 2qe6A-5ewqA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5ewq AMIDASE
(Bacillus
anthracis) 		5 / 12 VAL A  69
SER A 110
ALA A 237
ASP A 238
ARG A 291
 None
 1.42A 2qm9A-5ewqA:
undetectable		 2qm9A-5ewqA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 5ewq AMIDASE
(Bacillus
anthracis) 		5 / 7 ASN A 215
SER A 225
ALA A 257
ALA A 256
ALA A 254
 None
 1.36A 3a2qA-5ewqA:
38.0		 3a2qA-5ewqA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 5ewq AMIDASE
(Bacillus
anthracis) 		4 / 7 VAL A 448
SER A 451
THR A 282
LEU A 283
 None
 1.09A 3arrA-5ewqA:
undetectable		 3arrA-5ewqA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 5ewq AMIDASE
(Bacillus
anthracis) 		4 / 7 TYR A  94
LEU A  76
THR A 292
ASP A 238
 None
 1.03A 3fwgB-5ewqA:
undetectable		 3fwgB-5ewqA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 5ewq AMIDASE
(Bacillus
anthracis) 		4 / 8 ALA A 172
THR A 150
VAL A 244
VAL A 142
 None
 0.73A 3me6B-5ewqA:
undetectable		 3me6B-5ewqA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5ewq AMIDASE
(Bacillus
anthracis) 		5 / 11 GLN A 258
ALA A 189
GLY A 230
THR A 233
ALA A 232
 None
 1.30A 3mg0H-5ewqA:
undetectable
3mg0I-5ewqA:
undetectable		 3mg0H-5ewqA:
19.11
3mg0I-5ewqA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5ewq AMIDASE
(Bacillus
anthracis) 		6 / 11 GLN A 258
ALA A 254
ALA A 189
GLY A 230
THR A 233
ALA A 232
 None
 1.32A 3mg0V-5ewqA:
undetectable
3mg0W-5ewqA:
undetectable		 3mg0V-5ewqA:
19.11
3mg0W-5ewqA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5ewq AMIDASE
(Bacillus
anthracis) 		5 / 12 GLY A 230
GLY A 245
ALA A 243
ALA A 290
ALA A 296
 None
 1.07A 3sudA-5ewqA:
undetectable		 3sudA-5ewqA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5ewq AMIDASE
(Bacillus
anthracis) 		5 / 12 GLY A 230
GLY A 245
ALA A 243
ALA A 290
ALA A 296
 None
 1.03A 3sudD-5ewqA:
undetectable		 3sudD-5ewqA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5ewq AMIDASE
(Bacillus
anthracis) 		5 / 12 GLY A 245
ALA A 243
ALA A 290
ALA A 296
ASP A 295
 None
 1.02A 3sudD-5ewqA:
undetectable		 3sudD-5ewqA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 5ewq AMIDASE
(Bacillus
anthracis) 		4 / 7 SER A 227
GLY A 250
THR A 249
SER A 192
 None
 0.70A 4ac9C-5ewqA:
undetectable		 4ac9C-5ewqA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5ewq AMIDASE
(Bacillus
anthracis) 		4 / 7 ASP A 323
ASP A 295
ASN A 301
GLU A 181
 None
 1.11A 4fexB-5ewqA:
undetectable		 4fexB-5ewqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5ewq AMIDASE
(Bacillus
anthracis) 		4 / 8 ASP A 323
ASP A 295
ASN A 301
GLU A 181
 None
 1.12A 4gkhB-5ewqA:
undetectable		 4gkhB-5ewqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5ewq AMIDASE
(Bacillus
anthracis) 		4 / 8 ASP A 323
ASP A 295
ASN A 301
GLU A 181
 None
 1.13A 4gkiC-5ewqA:
undetectable		 4gkiC-5ewqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 5ewq AMIDASE
(Bacillus
anthracis) 		4 / 5 GLU A 247
SER A 228
ARG A 265
SER A 227
 None
 1.33A 4k17B-5ewqA:
undetectable		 4k17B-5ewqA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 5ewq AMIDASE
(Bacillus
anthracis) 		5 / 12 GLY A 250
ALA A 483
ALA A 286
ARG A 273
ASP A 284
 None
 1.17A 4kicA-5ewqA:
undetectable		 4kicA-5ewqA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 5ewq AMIDASE
(Bacillus
anthracis) 		4 / 7 TYR A  94
ALA A 122
ILE A 140
PHE A 184
 None
 1.03A 4uymA-5ewqA:
undetectable		 4uymA-5ewqA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 5ewq AMIDASE
(Bacillus
anthracis) 		4 / 7 TYR A  94
ALA A 122
ILE A 140
PHE A 184
 None
 0.99A 4uymB-5ewqA:
undetectable		 4uymB-5ewqA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 5ewq AMIDASE
(Bacillus
anthracis) 		4 / 5 LEU A 362
TYR A 524
ALA A 494
ASN A 530
 None
 1.09A 4y03B-5ewqA:
undetectable		 4y03B-5ewqA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5ewq AMIDASE
(Bacillus
anthracis) 		5 / 11 GLN A 258
ALA A 189
GLY A 230
THR A 233
ALA A 232
 None
 1.35A 5bxnV-5ewqA:
undetectable
5bxnW-5ewqA:
undetectable		 5bxnV-5ewqA:
19.26
5bxnW-5ewqA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 5ewq AMIDASE
(Bacillus
anthracis) 		4 / 4 VAL A 293
GLU A 525
GLY A 521
LEU A 490
 None
 1.27A 5g5gC-5ewqA:
undetectable		 5g5gC-5ewqA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5ewq AMIDASE
(Bacillus
anthracis) 		5 / 12 GLY A 230
MET A 191
ASN A 190
ALA A 158
ASN A 147
 None
 1.49A 5kc4A-5ewqA:
undetectable		 5kc4A-5ewqA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5ewq AMIDASE
(Bacillus
anthracis) 		5 / 9 VAL A 111
GLU A 100
LEU A  46
ASN A 104
ILE A  49
 None
 1.24A 5mzpA-5ewqA:
undetectable		 5mzpA-5ewqA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 5ewq AMIDASE
(Bacillus
anthracis) 		5 / 9 ALA A 243
ALA A 189
SER A 231
VAL A 148
GLY A 187
 None
 1.25A 6bklA-5ewqA:
undetectable
6bklB-5ewqA:
undetectable
6bklC-5ewqA:
undetectable
6bklD-5ewqA:
undetectable		 6bklA-5ewqA:
4.90
6bklB-5ewqA:
4.90
6bklC-5ewqA:
4.90
6bklD-5ewqA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 5ewq AMIDASE
(Bacillus
anthracis) 		4 / 6 SER A 227
ALA A 189
ALA A 232
SER A 231
 None
 0.89A 6bocA-5ewqA:
undetectable
6bocB-5ewqA:
undetectable
6bocC-5ewqA:
undetectable
6bocD-5ewqA:
undetectable		 6bocA-5ewqA:
4.90
6bocB-5ewqA:
4.90
6bocC-5ewqA:
4.90
6bocD-5ewqA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5ewq AMIDASE
(Bacillus
anthracis) 		4 / 4 ASP A 295
ILE A 140
PRO A 141
LEU A 242
 None
 1.15A 6mkeA-5ewqA:
undetectable		 6mkeA-5ewqA:
11.63