SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ewt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 5ewt EXODEOXYRIBONUCLEASE
III XTH
(Sulfolobus
islandicus) 		5 / 12 GLY A 154
ALA A 155
ILE A 161
GLY A 163
ILE A 147
 None
 0.99A 1c6zA-5ewtA:
undetectable		 1c6zA-5ewtA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 5ewt EXODEOXYRIBONUCLEASE
III XTH
(Sulfolobus
islandicus) 		5 / 12 GLY A 154
ALA A 155
ILE A 161
GLY A 163
ILE A 147
 None
 1.00A 1c6zB-5ewtA:
undetectable		 1c6zB-5ewtA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 5ewt EXODEOXYRIBONUCLEASE
III XTH
(Sulfolobus
islandicus) 		4 / 6 PHE A  28
LEU A  19
VAL A   8
VAL A   4
 None
 0.98A 1e7aB-5ewtA:
undetectable		 1e7aB-5ewtA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 5ewt EXODEOXYRIBONUCLEASE
III XTH
(Sulfolobus
islandicus) 		5 / 12 GLY A 154
ALA A 155
ILE A 161
GLY A 163
ILE A 147
 None
 1.07A 1sduB-5ewtA:
undetectable		 1sduB-5ewtA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 5ewt EXODEOXYRIBONUCLEASE
III XTH
(Sulfolobus
islandicus) 		5 / 12 ILE A  31
GLY A 143
ALA A 105
PHE A  28
PRO A 241
 None
 1.15A 1sg9C-5ewtA:
2.4		 1sg9C-5ewtA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 5ewt EXODEOXYRIBONUCLEASE
III XTH
(Sulfolobus
islandicus) 		5 / 10 GLY A 154
ALA A 155
ILE A 161
GLY A 163
ILE A 147
 None
 1.00A 1t7iA-5ewtA:
undetectable		 1t7iA-5ewtA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5ewt EXODEOXYRIBONUCLEASE
III XTH
(Sulfolobus
islandicus) 		3 / 3 ASN A 123
TRP A 171
GLN A 167
 None
 1.34A 1xoqA-5ewtA:
undetectable		 1xoqA-5ewtA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 5ewt EXODEOXYRIBONUCLEASE
III XTH
(Sulfolobus
islandicus) 		3 / 3 LEU A  80
ARG A  90
ILE A  82
 None
 0.57A 2xn5B-5ewtA:
undetectable		 2xn5B-5ewtA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 5ewt EXODEOXYRIBONUCLEASE
III XTH
(Sulfolobus
islandicus) 		5 / 10 GLY A 154
ALA A 155
ILE A 161
GLY A 163
ILE A 147
 None
 1.06A 3el9B-5ewtA:
undetectable		 3el9B-5ewtA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 5ewt EXODEOXYRIBONUCLEASE
III XTH
(Sulfolobus
islandicus) 		3 / 3 LYS A 119
ILE A 242
PHE A 184
 None
 0.91A 3j7zS-5ewtA:
undetectable
3j7za-5ewtA:
undetectable		 3j7zS-5ewtA:
18.83
3j7za-5ewtA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5ewt EXODEOXYRIBONUCLEASE
III XTH
(Sulfolobus
islandicus) 		3 / 3 ASN A 146
ASP A 213
ARG A  12
 None
 0.90A 3k13A-5ewtA:
undetectable		 3k13A-5ewtA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 5ewt EXODEOXYRIBONUCLEASE
III XTH
(Sulfolobus
islandicus) 		5 / 10 LEU A  80
LEU A 141
VAL A 101
THR A  93
PHE A 145
 None
 1.47A 3tbgC-5ewtA:
undetectable		 3tbgC-5ewtA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5ewt EXODEOXYRIBONUCLEASE
III XTH
(Sulfolobus
islandicus) 		4 / 6 ASP A 238
ASP A 144
ASP A 111
ASN A 146
 None
 1.35A 4gkhJ-5ewtA:
undetectable		 4gkhJ-5ewtA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 5ewt EXODEOXYRIBONUCLEASE
III XTH
(Sulfolobus
islandicus) 		5 / 12 GLY A 154
ALA A 155
ILE A 161
GLY A 163
ILE A 147
 None
 0.99A 4njvD-5ewtA:
undetectable		 4njvD-5ewtA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 5ewt EXODEOXYRIBONUCLEASE
III XTH
(Sulfolobus
islandicus) 		4 / 4 ASN A   7
LEU A 210
PHE A 106
TYR A 214
 None
 1.23A 4u14A-5ewtA:
undetectable		 4u14A-5ewtA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 5ewt EXODEOXYRIBONUCLEASE
III XTH
(Sulfolobus
islandicus) 		3 / 3 ASN A   7
PHE A 106
TYR A 214
 None
 0.90A 4u15A-5ewtA:
undetectable		 4u15A-5ewtA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 5ewt EXODEOXYRIBONUCLEASE
III XTH
(Sulfolobus
islandicus) 		5 / 12 LEU A  94
ILE A 102
ILE A  77
PHE A 106
VAL A  30
 None
 0.91A 6ajiA-5ewtA:
undetectable		 6ajiA-5ewtA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 5ewt EXODEOXYRIBONUCLEASE
III XTH
(Sulfolobus
islandicus) 		5 / 12 LEU A  94
ILE A 102
ILE A  77
PHE A 145
VAL A  30
 None
 1.17A 6ajiA-5ewtA:
undetectable		 6ajiA-5ewtA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 5ewt EXODEOXYRIBONUCLEASE
III XTH
(Sulfolobus
islandicus) 		4 / 5 ASN A   9
GLY A 209
HIS A 239
ASP A 144
 None
 1.19A 6gh9A-5ewtA:
undetectable		 6gh9A-5ewtA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 5ewt EXODEOXYRIBONUCLEASE
III XTH
(Sulfolobus
islandicus) 		4 / 5 ASN A 146
GLY A  10
HIS A 239
ASP A 213
 None
 1.05A 6gh9A-5ewtA:
undetectable		 6gh9A-5ewtA:
13.71