SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ewu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_B_LNRB200_1
(D7R4 PROTEIN)		 5ewu MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 GLU A1110
ILE A1135
ARG A1136
ASP A1102
ASP A1184
 None
 0.95A 2qeoB-5ewuA:
undetectable		 2qeoB-5ewuA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5ewu MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 GLY A1088
SER A1087
TRP A1033
 MG  A1402 (-3.9A)
BEZ  A1401 (-2.5A)
None
 0.92A 4e7cD-5ewuA:
1.6		 4e7cD-5ewuA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ewu MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 VAL A1084
LEU A1030
LEU A1045
MET A1107
 None
 1.01A 4o1zA-5ewuA:
undetectable		 4o1zA-5ewuA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5ewu MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 MET A1281
GLU A1291
GLU A1287
TYR A1286
 None
 1.37A 4r87I-5ewuA:
undetectable		 4r87I-5ewuA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5ewu MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 MET A1281
TRP A1277
GLU A1291
TYR A1286
 None
 1.23A 4r87J-5ewuA:
undetectable
4r87L-5ewuA:
undetectable		 4r87J-5ewuA:
19.85
4r87L-5ewuA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 5ewu MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		6 / 11 LEU A1030
VAL A1031
ASN A1085
PHE A1197
LEU A1201
SER A1227
 None
 1.48A 4zbqA-5ewuA:
undetectable		 4zbqA-5ewuA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_NPSA602_1
(SERUM ALBUMIN)		 5ewu MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A1030
ASN A1085
PHE A1197
LEU A1201
SER A1227
 None
 1.47A 5dbyA-5ewuA:
1.8		 5dbyA-5ewuA:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 5ewu MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		6 / 6 TRP A1033
GLY A1034
THR A1035
SER A1087
VAL A1089
HIS A1223
 None
BEZ  A1401 (-3.6A)
BEZ  A1401 (-2.6A)
BEZ  A1401 (-2.5A)
BEZ  A1401 (-4.0A)
BEZ  A1401 (-3.5A)
 0.00A 5ewuA-5ewuA:
68.6		 5ewuA-5ewuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 5ewu MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		6 / 6 TRP A1033
GLY A1034
THR A1035
SER A1087
VAL A1089
HIS A1223
 None
BEZ  A1401 (-3.6A)
BEZ  A1401 (-2.6A)
BEZ  A1401 (-2.5A)
BEZ  A1401 (-4.0A)
BEZ  A1401 (-3.5A)
 0.43A 5ewuB-5ewuA:
63.2		 5ewuB-5ewuA:
100.00