SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ewx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2E1Q_A_SALA2006_1 (XANTHINE DEHYDROGENASE/OXIDAS E)	5ewx	ENDOLYSIN,IMMUNOGLOB ULIN G-BINDING PROTEIN A,ENDOLYSIN (Escherichia virus T4; Staphylococcus aureus)	4 / 6	PHE A 153 VAL A 87 LEU A 118 ALA A 129	None	1.05A	2e1qA-5ewxA: undetectable	2e1qA-5ewxA: 10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2E1Q_C_SALC4006_1 (XANTHINE DEHYDROGENASE/OXIDAS E)	5ewx	ENDOLYSIN,IMMUNOGLOB ULIN G-BINDING PROTEIN A,ENDOLYSIN (Escherichia virus T4; Staphylococcus aureus)	4 / 6	PHE A 153 VAL A 87 LEU A 118 ALA A 129	None	1.04A	2e1qC-5ewxA: undetectable	2e1qC-5ewxA: 10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OCT_A_1N1A663_2 (TYROSINE-PROTEIN KINASE BTK)	5ewx	ENDOLYSIN,IMMUNOGLOB ULIN G-BINDING PROTEIN A,ENDOLYSIN (Escherichia virus T4; Staphylococcus aureus)	4 / 5	PHE A 4 ILE A 100 MET A 1 PHE A 104	None	1.21A	3octA-5ewxA: 1.8	3octA-5ewxA: 22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OBW_A_SAMA602_0 (2-METHOXY-6-POLYPREN YL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL)	5ewx	ENDOLYSIN,IMMUNOGLOB ULIN G-BINDING PROTEIN A,ENDOLYSIN (Staphylococcus aureus; Escherichia virus T4)	5 / 12	TYR A 161 ILE A 3 MET A 1 ASN A 101 PHE A 104	None	1.20A	4obwA-5ewxA: undetectable	4obwA-5ewxA: 20.56

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2E1Q_A_SALA2006_1","XANTHINE DEHYDROGENASE\/OXIDASE","5ewx","ENDOLYSIN,IMMUNOGLOBULIN G-BINDING PROTEIN A,ENDOLYSIN","Escherichia virus T4;Staphylococcus aureus",4,"PHE A 153;VAL A  87;LEU A 118;ALA A 129","None","1.05A","2e1qA-5ewxA:undetectable","2e1qA-5ewxA:10.33"],["2E1Q_C_SALC4006_1","XANTHINE DEHYDROGENASE\/OXIDASE","5ewx","ENDOLYSIN,IMMUNOGLOBULIN G-BINDING PROTEIN A,ENDOLYSIN","Escherichia virus T4;Staphylococcus aureus",4,"PHE A 153;VAL A  87;LEU A 118;ALA A 129","None","1.04A","2e1qC-5ewxA:undetectable","2e1qC-5ewxA:10.33"],["3OCT_A_1N1A663_2","TYROSINE-PROTEIN KINASE BTK","5ewx","ENDOLYSIN,IMMUNOGLOBULIN G-BINDING PROTEIN A,ENDOLYSIN","Escherichia virus T4;Staphylococcus aureus",4,"PHE A   4;ILE A 100;MET A   1;PHE A 104","None","1.21A","3octA-5ewxA:1.8","3octA-5ewxA:22.10"],["4OBW_A_SAMA602_0","2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL","5ewx","ENDOLYSIN,IMMUNOGLOBULIN G-BINDING PROTEIN A,ENDOLYSIN","Staphylococcus aureus;Escherichia virus T4",5,"TYR A 161;ILE A   3;MET A   1;ASN A 101;PHE A 104","None","1.20A","4obwA-5ewxA:undetectable","4obwA-5ewxA:20.56"]]