SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ex1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUM_H_BEZH1601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5ex1 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN TYPE
(Hirschia
baltica) 		5 / 9 ALA A 152
TYR A 167
LEU A 151
GLY A 184
GLY A 149
 None
 1.39A 1rumH-5ex1A:
undetectable
1rumL-5ex1A:
undetectable		 1rumH-5ex1A:
18.82
1rumL-5ex1A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 5ex1 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN TYPE
(Hirschia
baltica) 		4 / 5 PHE A  63
PHE A 166
PHE A  77
VAL A  38
 None
 1.24A 2lh6A-5ex1A:
undetectable		 2lh6A-5ex1A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5ex1 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN TYPE
(Hirschia
baltica) 		4 / 8 ILE A  40
PHE A  63
GLY A  88
GLY A  89
 None
 0.62A 2qx4A-5ex1A:
undetectable
2qx4B-5ex1A:
undetectable		 2qx4A-5ex1A:
22.92
2qx4B-5ex1A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5ex1 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN TYPE
(Hirschia
baltica) 		4 / 6 ILE A  40
PHE A  63
GLY A  88
GLY A  89
 None
 0.66A 2qx6A-5ex1A:
undetectable
2qx6B-5ex1A:
undetectable		 2qx6A-5ex1A:
22.92
2qx6B-5ex1A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5ex1 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN TYPE
(Hirschia
baltica) 		5 / 10 ILE A  32
MET A 153
PHE A 183
ALA A  61
ALA A  56
 None
 1.36A 3lw5B-5ex1A:
undetectable		 3lw5B-5ex1A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 5ex1 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN TYPE
(Hirschia
baltica) 		4 / 5 LEU A  51
GLY A 184
PHE A 183
PHE A  63
 None
 1.20A 3smtA-5ex1A:
undetectable		 3smtA-5ex1A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5ex1 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN TYPE
(Hirschia
baltica) 		4 / 4 LEU A  48
ILE A  49
GLY A 189
ILE A 168
 None
 0.85A 5dzk3-5ex1A:
undetectable
5dzkm-5ex1A:
undetectable		 5dzk3-5ex1A:
1.80
5dzkm-5ex1A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5ex1 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN TYPE
(Hirschia
baltica) 		4 / 4 ILE A  49
GLY A 189
ILE A 168
LEU A  48
 None
 0.90A 5dzkl-5ex1A:
undetectable
5dzkz-5ex1A:
undetectable		 5dzkl-5ex1A:
19.30
5dzkz-5ex1A:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 5ex1 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN TYPE
(Hirschia
baltica) 		5 / 12 LEU A  51
PHE A 166
GLY A 162
ILE A  49
THR A 169
 None
 1.06A 5veuH-5ex1A:
undetectable		 5veuH-5ex1A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 5ex1 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN TYPE
(Hirschia
baltica) 		4 / 5 GLY A 214
ASP A 215
ARG A 198
GLN A  87
 None
 1.39A 5zrfB-5ex1A:
undetectable		 5zrfB-5ex1A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 5ex1 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN TYPE
(Hirschia
baltica) 		4 / 6 GLN A  64
ASN A  36
LEU A 222
SER A 224
 None
 1.26A 6ekuA-5ex1A:
undetectable		 6ekuA-5ex1A:
17.22