SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ex2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 5ex2 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Hirschia
baltica) 		5 / 12 TYR A  58
LEU A 211
ILE A  49
GLY A 187
LEU A 171
 None
 0.96A 1cqeA-5ex2A:
undetectable		 1cqeA-5ex2A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 5ex2 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Hirschia
baltica) 		5 / 12 TYR A  58
LEU A 211
ILE A  49
GLY A 187
LEU A 171
 None
 0.97A 1cqeB-5ex2A:
undetectable		 1cqeB-5ex2A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5ex2 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Hirschia
baltica) 		5 / 12 TYR A  58
LEU A 211
ILE A  49
GLY A 187
LEU A 171
 None
 0.99A 1eqhA-5ex2A:
undetectable		 1eqhA-5ex2A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5ex2 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Hirschia
baltica) 		5 / 12 TYR A  58
LEU A 211
ILE A  49
GLY A 187
LEU A 171
 None
 0.95A 1eqhB-5ex2A:
undetectable		 1eqhB-5ex2A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ex2 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Hirschia
baltica) 		5 / 12 TYR A  58
LEU A 211
ILE A  49
GLY A 187
LEU A 171
 None
 0.96A 2aylB-5ex2A:
undetectable		 2aylB-5ex2A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 5ex2 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Hirschia
baltica) 		5 / 12 LEU A 211
GLN A 256
VAL A  52
VAL A 154
TRP A 186
 None
 1.30A 2qd4B-5ex2A:
undetectable		 2qd4B-5ex2A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ex2 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Hirschia
baltica) 		5 / 12 TYR A  58
LEU A 211
ILE A  49
GLY A 187
LEU A 171
 None
 1.00A 3n8xB-5ex2A:
undetectable		 3n8xB-5ex2A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 5ex2 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Hirschia
baltica) 		4 / 6 LEU A 190
GLU A  36
SER A 259
THR A 257
 None
 1.43A 3ropA-5ex2A:
undetectable		 3ropA-5ex2A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 5ex2 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Hirschia
baltica) 		3 / 3 VAL A 212
GLY A  60
LYS A  62
 None
 0.77A 4k50I-5ex2A:
undetectable		 4k50I-5ex2A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 5ex2 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Hirschia
baltica) 		4 / 6 ARG A 173
GLY A 192
ASP A 194
GLY A  31
 MG  A 302 (-4.1A)
None
None
None
 0.94A 4koeA-5ex2A:
undetectable
4koeB-5ex2A:
undetectable
4koeC-5ex2A:
undetectable		 4koeA-5ex2A:
18.70
4koeB-5ex2A:
18.70
4koeC-5ex2A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5ex2 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Hirschia
baltica) 		4 / 6 GLY A 192
ASP A 194
GLY A  31
ARG A 173
 None
None
None
MG  A 302 (-4.1A)
 0.92A 4z53A-5ex2A:
undetectable
4z53B-5ex2A:
undetectable		 4z53A-5ex2A:
17.21
4z53B-5ex2A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5ex2 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Hirschia
baltica) 		4 / 7 ARG A 173
GLY A 192
ASP A 194
GLY A  31
 MG  A 302 (-4.1A)
None
None
None
 0.96A 4z53A-5ex2A:
undetectable
4z53B-5ex2A:
undetectable		 4z53A-5ex2A:
17.21
4z53B-5ex2A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5ex2 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Hirschia
baltica) 		5 / 12 GLY A  60
ILE A  77
LEU A  81
GLY A  56
PHE A 169
 None
 0.78A 5d4uA-5ex2A:
undetectable		 5d4uA-5ex2A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5ex2 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Hirschia
baltica) 		5 / 12 GLY A  60
ILE A  77
LEU A  81
GLY A  56
PHE A 169
 None
 0.80A 5d4uB-5ex2A:
undetectable		 5d4uB-5ex2A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5ex2 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Hirschia
baltica) 		3 / 3 VAL A 251
HIS A 149
VAL A 153
 None
 0.66A 5jmnC-5ex2A:
undetectable		 5jmnC-5ex2A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 5ex2 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Hirschia
baltica) 		4 / 6 THR A 257
GLY A 124
PHE A 125
ILE A 103
 None
 0.77A 5kmfA-5ex2A:
undetectable
5kmfC-5ex2A:
undetectable		 5kmfA-5ex2A:
19.08
5kmfC-5ex2A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIY_A_OAQA302_0
(SULFOTRANSFERASE)		 5ex2 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Hirschia
baltica) 		5 / 11 ILE A 127
ASP A 180
VAL A 153
SER A 185
THR A 257
 None
 1.41A 5tiyA-5ex2A:
undetectable		 5tiyA-5ex2A:
19.23