SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ex6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		4 / 8 LEU C  99
HIS C  96
LEU C 348
LEU C  88
 None
HEM  C 502 (-3.9A)
HEM  C 502 ( 4.3A)
HEM  C 502 (-3.7A)
 1.07A 1e7cA-5ex6C:
3.3		 1e7cA-5ex6C:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		4 / 7 THR C  63
SER C  62
HIS C 345
LEU C 348
 None
None
HEM  C 502 (-3.6A)
HEM  C 502 ( 4.3A)
 1.14A 1ibgL-5ex6C:
undetectable		 1ibgL-5ex6C:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		5 / 12 LEU C 371
LEU C 252
ALA C 268
ALA C 272
VAL C 249
 None
 0.93A 1kt4A-5ex6C:
undetectable		 1kt4A-5ex6C:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		4 / 8 ILE C  73
GLY C  75
ILE C 292
GLU C 293
 None
 0.75A 1mrjA-5ex6C:
undetectable		 1mrjA-5ex6C:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		5 / 12 LEU C  88
ASN C  87
GLY C  86
ARG C  98
THR C 287
 HEM  C 502 (-3.7A)
None
None
None
HEM  C 502 (-3.5A)
 1.46A 1p93A-5ex6C:
2.4		 1p93A-5ex6C:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		5 / 10 LEU C 355
LEU C 352
ILE C 119
GLU C 201
LEU C 155
 None
HEM  C 502 ( 4.9A)
None
None
None
 1.02A 1wopA-5ex6C:
undetectable		 1wopA-5ex6C:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		4 / 7 ARG C 317
GLU C 275
ASN C 255
ALA C 251
 None
 1.13A 2ejgB-5ex6C:
undetectable		 2ejgB-5ex6C:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		5 / 12 MET C 233
GLU C 201
MET C 212
GLY C 106
LEU C 103
 HEM  C 502 (-3.7A)
None
None
None
None
 1.13A 2j7xA-5ex6C:
2.4		 2j7xA-5ex6C:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		5 / 12 GLY C 390
LEU C 252
GLY C 248
GLY C 246
LEU C 276
 None
 0.97A 2nxeB-5ex6C:
undetectable		 2nxeB-5ex6C:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		4 / 6 LEU C 357
TRP C 365
MET C 130
LEU C 139
 None
 1.26A 2oz7A-5ex6C:
undetectable		 2oz7A-5ex6C:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		5 / 9 LEU C 209
ILE C 210
GLY C 211
LEU C 103
GLU C 216
 None
 1.13A 3ai9X-5ex6C:
undetectable		 3ai9X-5ex6C:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		5 / 12 LEU C 139
LEU C 394
ILE C 391
THR C 380
LEU C 247
 None
 0.98A 3gcsA-5ex6C:
undetectable		 3gcsA-5ex6C:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		5 / 12 LEU C  88
ASN C  87
GLY C  86
ARG C  98
THR C 287
 HEM  C 502 (-3.7A)
None
None
None
HEM  C 502 (-3.5A)
 1.44A 3gn8A-5ex6C:
2.4		 3gn8A-5ex6C:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		5 / 12 LEU C  88
ASN C  87
GLY C  86
ARG C  98
THR C 287
 HEM  C 502 (-3.7A)
None
None
None
HEM  C 502 (-3.5A)
 1.42A 3gn8B-5ex6C:
undetectable		 3gn8B-5ex6C:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		5 / 12 MET C 244
LEU C 247
LEU C 250
ALA C 251
LEU C 276
 None
 0.98A 3olsA-5ex6C:
undetectable		 3olsA-5ex6C:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		5 / 12 LEU C 152
ALA C 353
GLY C 349
GLY C 237
ASP C 238
 HEM  C 502 (-4.9A)
HEM  C 502 ( 3.8A)
HEM  C 502 ( 3.7A)
HEM  C 502 (-3.5A)
None
 1.22A 3ou7A-5ex6C:
undetectable		 3ou7A-5ex6C:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		5 / 12 GLY C 246
ASP C 138
ILE C 140
GLY C 390
PHE C 382
 None
 1.20A 3ps9A-5ex6C:
undetectable		 3ps9A-5ex6C:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		4 / 6 PRO C 105
GLY C 106
LEU C 209
GLU C 216
 None
 1.01A 3zqtA-5ex6C:
undetectable		 3zqtA-5ex6C:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		4 / 6 ILE C 140
ASP C 145
GLY C 390
VAL C 282
 None
 1.03A 4oltA-5ex6C:
undetectable		 4oltA-5ex6C:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		4 / 6 ILE C 140
ASP C 145
GLY C 390
VAL C 282
 None
 1.07A 4oltB-5ex6C:
undetectable		 4oltB-5ex6C:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		5 / 12 LEU C  88
ASN C  87
GLY C  86
ARG C  98
THR C 287
 HEM  C 502 (-3.7A)
None
None
None
HEM  C 502 (-3.5A)
 1.48A 4p6xA-5ex6C:
2.0		 4p6xA-5ex6C:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		5 / 12 LEU C  88
ASN C  87
GLY C  86
ARG C  98
THR C 287
 HEM  C 502 (-3.7A)
None
None
None
HEM  C 502 (-3.5A)
 1.49A 4p6xE-5ex6C:
undetectable		 4p6xE-5ex6C:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		5 / 12 LEU C  88
ASN C  87
GLY C  86
ARG C  98
THR C 287
 HEM  C 502 (-3.7A)
None
None
None
HEM  C 502 (-3.5A)
 1.43A 4p6xI-5ex6C:
undetectable		 4p6xI-5ex6C:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		5 / 9 ALA C 261
LEU C 280
LEU C 252
ASN C 255
LEU C 276
 None
 1.34A 4x30A-5ex6C:
undetectable		 4x30A-5ex6C:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		3 / 3 VAL C 396
LEU C 280
MET C 244
 None
 0.73A 5ikrA-5ex6C:
undetectable		 5ikrA-5ex6C:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		5 / 12 VAL C 396
LEU C 280
MET C 244
GLY C 248
LEU C 253
 None
 1.18A 5iktB-5ex6C:
undetectable		 5iktB-5ex6C:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		3 / 3 GLN C 300
TRP C  43
VAL C 308
 None
 0.72A 6auuA-5ex6C:
2.1		 6auuA-5ex6C:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		4 / 7 ALA C 363
THR C 362
TYR C 361
VAL C 123
 None
 0.84A 6cduA-5ex6C:
1.5
6cduE-5ex6C:
1.5		 6cduA-5ex6C:
22.03
6cduE-5ex6C:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5ex6 CYTOCHROME P450
(Streptomyces
toyocaensis) 		4 / 7 VAL C 123
ALA C 363
THR C 362
TYR C 361
 None
 0.84A 6cduH-5ex6C:
undetectable
6cduI-5ex6C:
undetectable		 6cduH-5ex6C:
22.03
6cduI-5ex6C:
22.03