SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ex8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 5ex8 CYTOCHROME P450
(Streptomyces
toyocaensis) 		5 / 9 ILE A 217
LEU A 343
VAL A 225
GLY A  83
LEU A 205
 None
HEM  A 401 ( 4.0A)
None
None
None
 1.10A 1e7bA-5ex8A:
3.3		 1e7bA-5ex8A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 5ex8 CYTOCHROME P450
(Streptomyces
toyocaensis) 		4 / 8 LEU A  96
HIS A  93
LEU A 343
LEU A  85
 None
HEM  A 401 (-3.9A)
HEM  A 401 ( 4.0A)
HEM  A 401 (-3.9A)
 0.97A 1e7cA-5ex8A:
undetectable		 1e7cA-5ex8A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 5ex8 CYTOCHROME P450
(Streptomyces
toyocaensis) 		4 / 6 PHE A 112
LEU A 153
VAL A 229
MET A 230
 None
None
HEM  A 401 ( 4.3A)
None
 0.66A 1hk1A-5ex8A:
3.1		 1hk1A-5ex8A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 5ex8 CYTOCHROME P450
(Streptomyces
toyocaensis) 		4 / 7 PHE A 112
LEU A 153
VAL A 229
MET A 230
 None
None
HEM  A 401 ( 4.3A)
None
 0.67A 1hk3A-5ex8A:
2.7		 1hk3A-5ex8A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ex8 CYTOCHROME P450
(Streptomyces
toyocaensis) 		3 / 3 VAL A 225
ALA A 226
HIS A 193
 None
 0.73A 1q23J-5ex8A:
undetectable		 1q23J-5ex8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5ex8 CYTOCHROME P450
(Streptomyces
toyocaensis) 		3 / 3 ARG A 239
VAL A 137
TRP A 142
 EDO  A 409 (-4.3A)
EDO  A 409 (-4.5A)
EDO  A 409 (-4.2A)
 1.18A 1qwcA-5ex8A:
undetectable		 1qwcA-5ex8A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5ex8 CYTOCHROME P450
(Streptomyces
toyocaensis) 		4 / 7 PHE A 104
LEU A  85
GLY A  83
VAL A 209
 None
HEM  A 401 (-3.9A)
None
None
 0.97A 1t88A-5ex8A:
33.7		 1t88A-5ex8A:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5ex8 CYTOCHROME P450
(Streptomyces
toyocaensis) 		4 / 8 GLY A  74
THR A  75
ALA A  76
ALA A  77
 None
 0.52A 2ej3A-5ex8A:
undetectable		 2ej3A-5ex8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5ex8 CYTOCHROME P450
(Streptomyces
toyocaensis) 		5 / 12 PHE A 186
PHE A 228
GLY A 224
THR A 223
LEU A  85
 None
EDO  A 402 (-4.2A)
EDO  A 415 (-3.7A)
EDO  A 415 ( 4.3A)
HEM  A 401 (-3.9A)
 1.24A 2zifA-5ex8A:
undetectable		 2zifA-5ex8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5ex8 CYTOCHROME P450
(Streptomyces
toyocaensis) 		5 / 12 PHE A 186
PHE A 228
GLY A 224
THR A 223
LEU A  85
 None
EDO  A 402 (-4.2A)
EDO  A 415 (-3.7A)
EDO  A 415 ( 4.3A)
HEM  A 401 (-3.9A)
 1.20A 2zifB-5ex8A:
undetectable		 2zifB-5ex8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 5ex8 CYTOCHROME P450
(Streptomyces
toyocaensis) 		4 / 4 LEU A  61
ILE A 293
GLY A  62
PHE A  66
 None
None
EDO  A 410 (-3.6A)
None
 0.90A 4dc3A-5ex8A:
undetectable		 4dc3A-5ex8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 5ex8 CYTOCHROME P450
(Streptomyces
toyocaensis) 		4 / 6 ARG A  69
GLY A  78
ASP A  89
HIS A 340
 None
None
None
HEM  A 401 (-3.8A)
 1.24A 4lajA-5ex8A:
undetectable
4lajB-5ex8A:
undetectable		 4lajA-5ex8A:
21.06
4lajB-5ex8A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ex8 CYTOCHROME P450
(Streptomyces
toyocaensis) 		4 / 6 VAL A 249
LEU A 366
LEU A 387
MET A 273
 None
None
None
HEM  A 401 ( 4.9A)
 0.94A 4o1zA-5ex8A:
undetectable		 4o1zA-5ex8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5ex8 CYTOCHROME P450
(Streptomyces
toyocaensis) 		4 / 6 PHE A 228
GLY A  83
ILE A 217
LEU A 205
 EDO  A 402 (-4.2A)
None
None
None
 0.69A 4o8fB-5ex8A:
2.4		 4o8fB-5ex8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ex8 CYTOCHROME P450
(Streptomyces
toyocaensis) 		3 / 3 ARG A 239
VAL A 137
TRP A 142
 EDO  A 409 (-4.3A)
EDO  A 409 (-4.5A)
EDO  A 409 (-4.2A)
 1.08A 5fvoA-5ex8A:
undetectable		 5fvoA-5ex8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_A_IPHA101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5ex8 CYTOCHROME P450
(Streptomyces
toyocaensis) 		4 / 5 CYH A 306
HIS A 340
LEU A  61
HIS A 283
 None
HEM  A 401 (-3.8A)
None
HEM  A 401 ( 3.7A)
 1.47A 5hrqA-5ex8A:
undetectable
5hrqB-5ex8A:
undetectable
5hrqF-5ex8A:
undetectable		 5hrqA-5ex8A:
4.30
5hrqB-5ex8A:
5.71
5hrqF-5ex8A:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5ex8 CYTOCHROME P450
(Streptomyces
toyocaensis) 		4 / 6 HIS A 283
CYH A 306
HIS A 340
LEU A  61
 HEM  A 401 ( 3.7A)
None
HEM  A 401 (-3.8A)
None
 1.44A 5hrqH-5ex8A:
undetectable
5hrqK-5ex8A:
undetectable
5hrqL-5ex8A:
undetectable		 5hrqH-5ex8A:
5.71
5hrqK-5ex8A:
4.30
5hrqL-5ex8A:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5ex8 CYTOCHROME P450
(Streptomyces
toyocaensis) 		5 / 12 ILE A 217
ALA A 216
GLY A 210
GLY A  83
VAL A 225
 None
 1.11A 5i75A-5ex8A:
2.0		 5i75A-5ex8A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5ex8 CYTOCHROME P450
(Streptomyces
toyocaensis) 		3 / 3 LYS A 281
ASP A 279
ARG A  16
 None
EDO  A 407 ( 3.5A)
None
 1.08A 5jwaA-5ex8A:
undetectable
5jwaH-5ex8A:
undetectable		 5jwaA-5ex8A:
21.77
5jwaH-5ex8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 5ex8 CYTOCHROME P450
(Streptomyces
toyocaensis) 		4 / 8 ILE A 375
TYR A 275
VAL A 249
ASP A 370
 EDO  A 408 ( 4.4A)
None
None
None
 1.09A 5vlmF-5ex8A:
undetectable		 5vlmF-5ex8A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ex8 CYTOCHROME P450
(Streptomyces
toyocaensis) 		3 / 3 GLN A 296
TRP A  49
VAL A 304
 None
 0.74A 6auuA-5ex8A:
undetectable		 6auuA-5ex8A:
20.90