SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5exe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		4 / 8 CYH C 135
ASP C 137
GLY C 111
GLY C 112
 None
None
5SR  C 402 (-3.4A)
5SR  C 402 (-4.0A)
 0.91A 1ekjA-5exeC:
undetectable
1ekjB-5exeC:
undetectable		 1ekjA-5exeC:
22.36
1ekjB-5exeC:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		4 / 7 CYH C 135
ASP C 137
GLY C 111
GLY C 112
 None
None
5SR  C 402 (-3.4A)
5SR  C 402 (-4.0A)
 0.85A 1ekjE-5exeC:
undetectable
1ekjF-5exeC:
undetectable		 1ekjE-5exeC:
22.36
1ekjF-5exeC:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		4 / 8 CYH C 135
ASP C 137
GLY C 111
GLY C 112
 None
None
5SR  C 402 (-3.4A)
5SR  C 402 (-4.0A)
 0.88A 1ekjE-5exeC:
undetectable
1ekjF-5exeC:
undetectable		 1ekjE-5exeC:
22.36
1ekjF-5exeC:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 8 PHE A 298
ALA A 293
PHE A 267
VAL A 292
 None
 0.83A 1epbB-5exeA:
undetectable		 1epbB-5exeA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		3 / 4 VAL B  63
TRP B  49
TRP B  18
 None
 1.44A 1gmkC-5exeB:
undetectable
1gmkD-5exeB:
undetectable		 1gmkC-5exeB:
3.52
1gmkD-5exeB:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		5 / 11 ALA B  38
LEU B 186
LEU B  35
ILE B 170
ALA B 167
 None
 1.04A 1ha2A-5exeB:
undetectable		 1ha2A-5exeB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		4 / 8 VAL C 114
PRO C 179
HIS C 222
GLU C 139
 None
 0.94A 1jtvA-5exeC:
2.2		 1jtvA-5exeC:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 12 GLY A  97
SER A  96
GLU A  98
ILE A 208
HIS A 197
 None
 1.21A 1kyvA-5exeA:
4.2
1kyvE-5exeA:
6.0		 1kyvA-5exeA:
17.81
1kyvE-5exeA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 11 ILE A 208
HIS A 197
GLY A  97
SER A  96
GLU A  98
 None
 1.18A 1kyvA-5exeA:
4.2
1kyvB-5exeA:
3.1		 1kyvA-5exeA:
17.81
1kyvB-5exeA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 12 ILE A 208
HIS A 197
GLY A  97
SER A  96
GLU A  98
 None
 1.19A 1kyvB-5exeA:
3.1
1kyvC-5exeA:
3.1		 1kyvB-5exeA:
17.81
1kyvC-5exeA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 12 ILE A 208
HIS A 197
GLY A  97
SER A  96
GLU A  98
 None
 1.19A 1kyvC-5exeA:
3.1
1kyvD-5exeA:
3.2		 1kyvC-5exeA:
17.81
1kyvD-5exeA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 12 ILE A 208
HIS A 197
GLY A  97
SER A  96
GLU A  98
 None
 1.18A 1kyvD-5exeA:
3.2
1kyvE-5exeA:
6.1		 1kyvD-5exeA:
17.81
1kyvE-5exeA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica;
Moorella
thermoacetica) 		5 / 12 GLY C 145
THR C 144
GLY A  35
SER A  38
TYR A  33
 None
5SR  C 402 (-3.6A)
None
None
None
 1.25A 1nbiC-5exeC:
2.4		 1nbiC-5exeC:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica;
Moorella
thermoacetica) 		5 / 12 GLY C 145
THR C 144
GLY A  35
SER A  38
TYR A  33
 None
5SR  C 402 (-3.6A)
None
None
None
 1.26A 1nbiD-5exeC:
2.8		 1nbiD-5exeC:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		5 / 12 LEU B  35
THR B  36
ALA B  39
GLU B  42
ILE B  87
 None
 0.73A 1qknA-5exeB:
undetectable		 1qknA-5exeB:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 VAL A 363
VAL A 279
PHE A 372
GLU A 367
 None
 1.05A 1zzrA-5exeA:
undetectable
1zzrB-5exeA:
undetectable		 1zzrA-5exeA:
22.34
1zzrB-5exeA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 PHE A 372
GLU A 367
VAL A 363
VAL A 279
 None
 1.04A 1zzrA-5exeA:
undetectable
1zzrB-5exeA:
undetectable		 1zzrA-5exeA:
22.34
1zzrB-5exeA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 VAL A 363
VAL A 279
PHE A 372
GLU A 367
 None
 1.04A 1zzuA-5exeA:
undetectable
1zzuB-5exeA:
undetectable		 1zzuA-5exeA:
22.34
1zzuB-5exeA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 PHE A 372
GLU A 367
VAL A 363
VAL A 279
 None
 1.06A 1zzuA-5exeA:
undetectable
1zzuB-5exeA:
undetectable		 1zzuA-5exeA:
22.34
1zzuB-5exeA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 11 GLY A  97
SER A  96
GLU A  98
ILE A 208
HIS A 197
 None
 1.17A 2a58A-5exeA:
5.7
2a58E-5exeA:
3.2		 2a58A-5exeA:
18.32
2a58E-5exeA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 12 ILE A 208
HIS A 197
GLY A  97
SER A  96
GLU A  98
 None
 1.15A 2a58A-5exeA:
5.7
2a58B-5exeA:
5.8		 2a58A-5exeA:
18.32
2a58B-5exeA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 12 ILE A 208
HIS A 197
GLY A  97
SER A  96
GLU A  98
 None
 1.16A 2a58B-5exeA:
5.7
2a58C-5exeA:
3.2		 2a58B-5exeA:
18.32
2a58C-5exeA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 11 ILE A 208
HIS A 197
GLY A  97
SER A  96
GLU A  98
 None
 1.16A 2a58C-5exeA:
3.2
2a58D-5exeA:
3.2		 2a58C-5exeA:
18.32
2a58D-5exeA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 12 ILE A 208
HIS A 197
GLY A  97
SER A  96
GLU A  98
 None
 1.15A 2a58D-5exeA:
3.2
2a58E-5exeA:
3.2		 2a58D-5exeA:
18.32
2a58E-5exeA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 8 ASP A 168
GLY A 360
PHE A 117
ASP A 116
 None
None
None
5SR  C 402 (-3.3A)
 0.92A 2aouA-5exeA:
2.2		 2aouA-5exeA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		4 / 8 TYR A 170
ARG B  29
GLU B  50
VAL A  11
 None
 1.16A 2fl5E-5exeA:
undetectable
2fl5F-5exeA:
undetectable		 2fl5E-5exeA:
20.98
2fl5F-5exeA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		3 / 3 LYS C 180
TYR C 252
PRO C 179
 None
 1.27A 2j9cC-5exeC:
undetectable		 2j9cC-5exeC:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		4 / 5 ALA B  34
ALA B 195
ALA B 144
VAL B 147
 None
 0.89A 2nyrB-5exeB:
2.2		 2nyrB-5exeB:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		3 / 3 LEU B  95
ASN B 248
ARG B  20
 None
 0.93A 2qhfA-5exeB:
undetectable		 2qhfA-5exeB:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		4 / 8 TYR B 200
MET B 196
ALA B  34
ALA B  38
 None
 0.87A 2wx2B-5exeB:
undetectable		 2wx2B-5exeB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 5 ARG A 152
ALA A 238
ASP A 240
GLU A 241
 None
 1.35A 2xrzA-5exeA:
undetectable		 2xrzA-5exeA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 VAL A 363
VAL A 279
PHE A 372
GLU A 367
 None
 0.98A 3dqrA-5exeA:
undetectable
3dqrB-5exeA:
undetectable		 3dqrA-5exeA:
22.25
3dqrB-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 PHE A 372
GLU A 367
VAL A 363
VAL A 279
 None
 1.03A 3dqrA-5exeA:
undetectable
3dqrB-5exeA:
undetectable		 3dqrA-5exeA:
22.25
3dqrB-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		5 / 12 VAL B  32
ALA B  38
ALA B  39
LEU B 186
VAL B  17
 None
 0.84A 3fc6C-5exeB:
undetectable		 3fc6C-5exeB:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica;
Moorella
thermoacetica) 		5 / 12 ILE C   5
VAL C 201
ILE B 269
ILE C 197
ALA C  39
 None
 0.99A 3fpjA-5exeC:
2.5		 3fpjA-5exeC:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		5 / 12 GLY B 172
ALA B 177
THR B 178
ALA B 203
ALA B 167
 None
 1.00A 3g89A-5exeB:
undetectable		 3g89A-5exeB:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		5 / 11 GLY B 172
ALA B 177
THR B 178
ALA B 203
ALA B 167
 None
 1.01A 3g89B-5exeB:
undetectable		 3g89B-5exeB:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		5 / 12 GLY B 172
ALA B 177
THR B 178
ALA B 203
ALA B 167
 None
 0.99A 3g8bA-5exeB:
undetectable		 3g8bA-5exeB:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		5 / 12 GLY B 172
ALA B 177
THR B 178
ALA B 203
ALA B 167
 None
 0.99A 3g8bB-5exeB:
undetectable		 3g8bB-5exeB:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 12 ASP A 183
ASP A 180
ILE A 181
ASP A  21
LEU A  19
 None
 1.31A 3iv6B-5exeA:
undetectable		 3iv6B-5exeA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 VAL A 363
VAL A 279
PHE A 372
GLU A 367
 None
 1.00A 3jx2A-5exeA:
undetectable
3jx2B-5exeA:
undetectable		 3jx2A-5exeA:
22.25
3jx2B-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 PHE A 372
GLU A 367
VAL A 363
VAL A 279
 None
 1.01A 3jx2A-5exeA:
undetectable
3jx2B-5exeA:
undetectable		 3jx2A-5exeA:
22.25
3jx2B-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 VAL A 363
VAL A 279
PHE A 372
GLU A 367
 None
 1.04A 3jx3A-5exeA:
undetectable
3jx3B-5exeA:
undetectable		 3jx3A-5exeA:
22.25
3jx3B-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 PHE A 372
GLU A 367
VAL A 363
VAL A 279
 None
 1.03A 3jx3A-5exeA:
undetectable
3jx3B-5exeA:
undetectable		 3jx3A-5exeA:
22.25
3jx3B-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 PHE A 372
GLU A 367
VAL A 363
VAL A 279
 None
 0.99A 3jx4A-5exeA:
undetectable
3jx4B-5exeA:
undetectable		 3jx4A-5exeA:
22.25
3jx4B-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 VAL A 363
VAL A 279
PHE A 372
GLU A 367
 None
 1.04A 3jx5A-5exeA:
undetectable
3jx5B-5exeA:
undetectable		 3jx5A-5exeA:
22.25
3jx5B-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 PHE A 372
GLU A 367
VAL A 363
VAL A 279
 None
 0.97A 3jx5A-5exeA:
undetectable
3jx5B-5exeA:
undetectable		 3jx5A-5exeA:
22.25
3jx5B-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 VAL A 363
VAL A 279
PHE A 372
GLU A 367
 None
 0.98A 3jx6A-5exeA:
1.0
3jx6B-5exeA:
undetectable		 3jx6A-5exeA:
22.25
3jx6B-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 PHE A 372
GLU A 367
VAL A 363
VAL A 279
 None
 1.09A 3jx6A-5exeA:
1.0
3jx6B-5exeA:
undetectable		 3jx6A-5exeA:
22.25
3jx6B-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 GLY A 154
CYH A 239
PHE A 242
PHE A 190
 None
 0.87A 3ko0D-5exeA:
undetectable
3ko0E-5exeA:
undetectable		 3ko0D-5exeA:
11.84
3ko0E-5exeA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 8 CYH A 239
PHE A 242
PHE A 190
GLY A 154
 None
 0.63A 3ko0O-5exeA:
undetectable
3ko0Q-5exeA:
undetectable		 3ko0O-5exeA:
11.84
3ko0Q-5exeA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 9 ILE A 149
GLU A 142
ARG A 294
ASP A 255
LEU A 235
 None
 1.46A 3mjrA-5exeA:
undetectable		 3mjrA-5exeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 9 ILE A 327
GLU A 337
GLN A 269
ARG A 299
ARG A 128
 None
 1.20A 3mjrA-5exeA:
undetectable		 3mjrA-5exeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 6 VAL A 363
VAL A 279
PHE A 372
GLU A 367
 None
 1.00A 3n61A-5exeA:
undetectable
3n61B-5exeA:
undetectable		 3n61A-5exeA:
22.25
3n61B-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 PHE A 372
GLU A 367
VAL A 363
VAL A 279
 None
 0.99A 3n61A-5exeA:
undetectable
3n61B-5exeA:
undetectable		 3n61A-5exeA:
22.25
3n61B-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 VAL A 363
VAL A 279
PHE A 372
GLU A 367
 None
 0.99A 3nljA-5exeA:
undetectable
3nljB-5exeA:
undetectable		 3nljA-5exeA:
22.25
3nljB-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 PHE A 372
GLU A 367
VAL A 363
VAL A 279
 None
 1.00A 3nljA-5exeA:
undetectable
3nljB-5exeA:
undetectable		 3nljA-5exeA:
22.25
3nljB-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 VAL A 363
VAL A 279
PHE A 372
GLU A 367
 None
 1.03A 3nlpA-5exeA:
undetectable
3nlpB-5exeA:
undetectable		 3nlpA-5exeA:
22.25
3nlpB-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 PHE A 372
GLU A 367
VAL A 363
VAL A 279
 None
 1.02A 3nlpA-5exeA:
undetectable
3nlpB-5exeA:
undetectable		 3nlpA-5exeA:
22.25
3nlpB-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 8 VAL A 363
VAL A 279
PHE A 372
GLU A 367
 None
 1.06A 3nlqA-5exeA:
undetectable
3nlqB-5exeA:
undetectable		 3nlqA-5exeA:
22.25
3nlqB-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 PHE A 372
GLU A 367
VAL A 363
VAL A 279
 None
 0.99A 3nlqA-5exeA:
undetectable
3nlqB-5exeA:
undetectable		 3nlqA-5exeA:
22.25
3nlqB-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 VAL A 363
VAL A 279
PHE A 372
GLU A 367
 None
 1.08A 3nlrA-5exeA:
undetectable
3nlrB-5exeA:
undetectable		 3nlrA-5exeA:
22.25
3nlrB-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 8 PHE A 372
GLU A 367
VAL A 363
VAL A 279
 None
 1.05A 3nlrA-5exeA:
undetectable
3nlrB-5exeA:
undetectable		 3nlrA-5exeA:
22.25
3nlrB-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		4 / 7 ILE C 219
LEU C 132
ALA C  39
ALA C  40
 None
 0.81A 3r9tB-5exeC:
undetectable		 3r9tB-5exeC:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 VAL A 363
VAL A 279
PHE A 372
GLU A 367
 None
 1.04A 4cx3A-5exeA:
undetectable
4cx3B-5exeA:
undetectable		 4cx3A-5exeA:
22.25
4cx3B-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 PHE A 372
GLU A 367
VAL A 363
VAL A 279
 None
 1.04A 4cx3A-5exeA:
undetectable
4cx3B-5exeA:
undetectable		 4cx3A-5exeA:
22.25
4cx3B-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 VAL A 363
VAL A 279
PHE A 372
GLU A 367
 None
 1.03A 4cx4A-5exeA:
undetectable
4cx4B-5exeA:
undetectable		 4cx4A-5exeA:
22.25
4cx4B-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 PHE A 372
GLU A 367
VAL A 363
VAL A 279
 None
 1.04A 4cx4A-5exeA:
undetectable
4cx4B-5exeA:
undetectable		 4cx4A-5exeA:
22.25
4cx4B-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 12 ASP A 123
THR A  78
ALA A 165
TYR A  92
CYH A 127
 None
 1.42A 4dajA-5exeA:
undetectable		 4dajA-5exeA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 11 ILE A 391
ALA A 356
GLY A 357
GLU A 120
GLY A 268
 None
 1.25A 4e47A-5exeA:
undetectable		 4e47A-5exeA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 11 ILE A 391
ALA A 356
GLY A 357
GLU A 120
GLY A 268
 None
 1.25A 4e47B-5exeA:
undetectable		 4e47B-5exeA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 11 ILE A 391
ALA A 356
GLY A 357
GLU A 120
GLY A 268
 None
 1.25A 4e47C-5exeA:
undetectable		 4e47C-5exeA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		4 / 8 ASP B  57
ASN C 143
CYH C  52
GLU B 154
 None
5SR  C 402 (-4.4A)
SF4  C 401 ( 2.3A)
None
 1.16A 4feuF-5exeB:
undetectable		 4feuF-5exeB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		4 / 8 ASP B  57
ASN C 143
CYH C  52
GLU B 154
 None
5SR  C 402 (-4.4A)
SF4  C 401 ( 2.3A)
None
 1.19A 4fewD-5exeB:
undetectable		 4fewD-5exeB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		4 / 8 ASP B  57
ASN C 143
CYH C  52
GLU B 154
 None
5SR  C 402 (-4.4A)
SF4  C 401 ( 2.3A)
None
 1.17A 4fewF-5exeB:
undetectable		 4fewF-5exeB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		4 / 8 ASP B  57
ASN C 143
CYH C  52
GLU B 154
 None
5SR  C 402 (-4.4A)
SF4  C 401 ( 2.3A)
None
 1.18A 4gkhB-5exeB:
undetectable		 4gkhB-5exeB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		4 / 8 ASP B  57
ASN C 143
CYH C  52
GLU B 154
 None
5SR  C 402 (-4.4A)
SF4  C 401 ( 2.3A)
None
 1.16A 4gkhD-5exeB:
undetectable		 4gkhD-5exeB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		4 / 8 ASP B  57
ASN C 143
CYH C  52
GLU B 154
 None
5SR  C 402 (-4.4A)
SF4  C 401 ( 2.3A)
None
 1.18A 4gkiA-5exeB:
undetectable		 4gkiA-5exeB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		4 / 8 ASP B  57
ASN C 143
CYH C  52
GLU B 154
 None
5SR  C 402 (-4.4A)
SF4  C 401 ( 2.3A)
None
 1.15A 4gkiC-5exeB:
undetectable		 4gkiC-5exeB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 11 ILE A 391
ALA A 356
GLY A 357
GLU A 120
GLY A 268
 None
 1.25A 4jdsA-5exeA:
undetectable		 4jdsA-5exeA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 11 ILE A 391
ALA A 356
GLY A 357
GLU A 120
GLY A 268
 None
 1.26A 4jdsB-5exeA:
undetectable		 4jdsB-5exeA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 11 ILE A 391
ALA A 356
GLY A 357
GLU A 120
GLY A 268
 None
 1.24A 4jdsC-5exeA:
undetectable		 4jdsC-5exeA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		5 / 12 ALA C 113
GLY C 111
SER C 149
GLY C  77
PHE C 133
 None
5SR  C 402 (-3.4A)
None
None
None
 1.26A 4obwA-5exeC:
2.9		 4obwA-5exeC:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		5 / 11 GLY C  77
GLY C  78
MET C 124
ILE C  47
GLY C  51
 None
None
None
None
5SR  C 402 (-3.3A)
 0.95A 4qoiA-5exeC:
undetectable
4qoiB-5exeC:
undetectable		 4qoiA-5exeC:
20.86
4qoiB-5exeC:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		5 / 11 CYH C 225
GLY C 145
THR C 144
ALA C 142
CYH C  52
 SF4  C 401 (-2.3A)
None
5SR  C 402 (-3.6A)
5SR  C 402 (-3.2A)
SF4  C 401 ( 2.3A)
 1.47A 4qvnH-5exeC:
undetectable
4qvnI-5exeC:
undetectable		 4qvnH-5exeC:
22.49
4qvnI-5exeC:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		5 / 11 CYH C 225
GLY C 145
THR C 144
ALA C 142
CYH C  52
 SF4  C 401 (-2.3A)
None
5SR  C 402 (-3.6A)
5SR  C 402 (-3.2A)
SF4  C 401 ( 2.3A)
 1.46A 4qvqH-5exeC:
undetectable
4qvqI-5exeC:
undetectable		 4qvqH-5exeC:
22.49
4qvqI-5exeC:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		5 / 11 CYH C 225
GLY C 145
THR C 144
ALA C 142
CYH C  52
 SF4  C 401 (-2.3A)
None
5SR  C 402 (-3.6A)
5SR  C 402 (-3.2A)
SF4  C 401 ( 2.3A)
 1.47A 4qvqV-5exeC:
undetectable
4qvqW-5exeC:
undetectable		 4qvqV-5exeC:
22.49
4qvqW-5exeC:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		5 / 12 PHE C 133
ALA C 108
LEU C 118
LEU C 189
LEU C 125
 None
 1.16A 4qzuC-5exeC:
undetectable		 4qzuC-5exeC:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 PHE A 372
GLU A 367
VAL A 363
VAL A 279
 None
 1.05A 5addA-5exeA:
undetectable
5addB-5exeA:
undetectable		 5addA-5exeA:
22.25
5addB-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 PHE A 372
GLU A 367
VAL A 363
VAL A 279
 None
 1.03A 5adeA-5exeA:
undetectable
5adeB-5exeA:
undetectable		 5adeA-5exeA:
22.25
5adeB-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 11 ILE A 391
ALA A 356
GLY A 357
GLU A 120
GLY A 268
 None
 1.28A 5ayfA-5exeA:
undetectable		 5ayfA-5exeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 VAL A 363
VAL A 279
PHE A 372
GLU A 367
 None
 1.01A 5g0pA-5exeA:
undetectable
5g0pB-5exeA:
undetectable		 5g0pA-5exeA:
22.25
5g0pB-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 PHE A 372
GLU A 367
VAL A 363
VAL A 279
 None
 1.00A 5g0pA-5exeA:
undetectable
5g0pB-5exeA:
undetectable		 5g0pA-5exeA:
22.25
5g0pB-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica;
Moorella
thermoacetica) 		5 / 12 ALA A  51
THR C 148
GLN C 147
SER A  38
THR A  34
 None
 0.97A 5hfjB-5exeA:
undetectable		 5hfjB-5exeA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 12 ASP A  46
ALA A  45
THR A  34
THR A  78
GLU A  39
 None
 1.28A 5hfjC-5exeA:
undetectable		 5hfjC-5exeA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		6 / 12 PRO C  12
ALA C  11
LEU C  31
LEU C   2
ILE C 105
MET C 107
 None
 1.46A 5hv1A-5exeC:
undetectable		 5hv1A-5exeC:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		5 / 11 ASP C 177
ARG C 299
PHE C 249
TYR C 218
ILE C 182
 None
 1.30A 5hw8B-5exeC:
undetectable		 5hw8B-5exeC:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 12 GLU A 142
ASP A 168
GLY A 270
MET A 273
ALA A 293
 None
 1.37A 5kc4A-5exeA:
undetectable		 5kc4A-5exeA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		3 / 3 THR C 194
PRO C 179
ASP C 177
 None
 0.94A 5l8dB-5exeC:
undetectable		 5l8dB-5exeC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		4 / 4 GLN B 134
THR B 178
THR B  16
LEU B  90
 None
 1.48A 5m5kA-5exeB:
3.9		 5m5kA-5exeB:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		3 / 3 THR C 194
PRO C 179
ASP C 177
 None
 0.94A 5mwuB-5exeC:
undetectable		 5mwuB-5exeC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		5 / 12 LEU B 186
ALA B  38
ILE B  31
ALA B 171
ILE B  15
 None
 1.27A 5nm5B-5exeB:
undetectable		 5nm5B-5exeB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 8 GLY A  73
ARG A 203
VAL A 199
ASP A 201
 None
 1.07A 5vlmA-5exeA:
undetectable		 5vlmA-5exeA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica;
Moorella
thermoacetica) 		5 / 12 TYR A  28
GLY C 112
LEU C 121
CYH C 135
ASP C 115
 5SR  C 402 (-4.9A)
5SR  C 402 (-4.0A)
None
None
None
 1.26A 5yniA-5exeA:
undetectable		 5yniA-5exeA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		5 / 9 VAL C 181
GLY C 112
TYR C 218
ASP C 110
GLY C 109
 None
5SR  C 402 (-4.0A)
None
MG  C 403 ( 2.5A)
5SR  C 402 (-3.5A)
 1.30A 5zniA-5exeC:
undetectable		 5zniA-5exeC:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		5 / 9 VAL B 174
GLY B 163
VAL B 190
ASP B  27
GLY B 165
 None
 1.38A 5zniA-5exeB:
undetectable		 5zniA-5exeB:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		5 / 12 GLY B 172
ILE B  69
GLY B 179
ALA B  38
ALA B  39
 None
 1.07A 6c2mD-5exeB:
undetectable		 6c2mD-5exeB:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		5 / 11 ALA B  19
VAL B  17
VAL B 112
ALA B 173
ALA B 140
 None
 1.09A 6h1lB-5exeB:
undetectable		 6h1lB-5exeB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica;
Moorella
thermoacetica) 		4 / 6 ASP B  54
TYR B  66
GLU B  81
GLU A 361
 None
 1.46A 6mn5A-5exeB:
undetectable		 6mn5A-5exeB:
13.56