SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5exk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 GLN A 270
LEU A 233
LEU A 220
SER A 226
 None
 1.08A 1hk3A-5exkA:
undetectable		 1hk3A-5exkA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 4 GLY A 221
LEU A 220
GLY A 223
ARG A 261
 None
 1.38A 1j7kA-5exkA:
undetectable		 1j7kA-5exkA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 159
GLY A 132
PHE A 170
GLY A 161
VAL A 203
 None
 1.33A 2fqyA-5exkA:
undetectable		 2fqyA-5exkA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A  83
VAL A  54
THR A 121
 None
None
MET  A 404 (-3.7A)
 0.83A 2nmzA-5exkA:
undetectable		 2nmzA-5exkA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 PRO A 193
ILE A 191
ARG A 192
ASP A  86
 None
None
MET  A 404 ( 2.9A)
IMD  A 405 (-3.9A)
 1.50A 2rhmD-5exkA:
1.5		 2rhmD-5exkA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 PHE A 195
CYH A  85
PHE A  87
 MET  A 404 ( 4.4A)
SF4  A 402 ( 2.3A)
SF4  A 402 ( 4.6A)
 1.08A 3cr5X-5exkA:
undetectable		 3cr5X-5exkA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 243
ALA A 295
GLU A 153
LEU A 155
VAL A 244
 None
None
None
MET  A 404 ( 4.6A)
None
 1.13A 3ix9A-5exkA:
undetectable		 3ix9A-5exkA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A  83
VAL A  54
THR A 121
 None
None
MET  A 404 (-3.7A)
 0.76A 3k4vD-5exkA:
undetectable		 3k4vD-5exkA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  76
ALA A 138
VAL A 169
ALA A 207
LEU A 212
 None
 1.17A 3ozuA-5exkA:
undetectable		 3ozuA-5exkA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 151
THR A 150
LEU A 115
GLU A 175
 None
 1.03A 3ps9A-5exkA:
undetectable		 3ps9A-5exkA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 229
SER A 226
GLY A 221
ARG A 261
 None
 1.39A 3v4tA-5exkA:
undetectable
3v4tD-5exkA:
undetectable		 3v4tA-5exkA:
24.31
3v4tD-5exkA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 127
TYR A 136
GLY A 132
GLY A  93
ASP A 126
 None
 1.14A 4blvB-5exkA:
undetectable		 4blvB-5exkA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 9 THR A 139
LEU A  98
LEU A 135
GLY A  77
VAL A 106
 None
 1.36A 4c9kB-5exkA:
undetectable		 4c9kB-5exkA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 210
ALA A 206
LEU A 204
SER A 172
VAL A 169
 None
 1.07A 4or0A-5exkA:
undetectable		 4or0A-5exkA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 9 ALA A 210
ALA A 206
LEU A 204
LEU A 166
SER A 172
VAL A 169
 None
 1.25A 4or0B-5exkA:
undetectable		 4or0B-5exkA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 6 GLY A  50
GLU A  49
ASP A  99
ASP A  79
 None
 0.91A 4uckB-5exkA:
undetectable		 4uckB-5exkA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 282
VAL A 283
GLU A 276
VAL A 244
LEU A 233
 None
 1.12A 4yb6A-5exkA:
undetectable
4yb6E-5exkA:
undetectable		 4yb6A-5exkA:
22.50
4yb6E-5exkA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 282
VAL A 283
GLU A 276
VAL A 244
LEU A 233
 None
 1.12A 4yb6B-5exkA:
undetectable
4yb6C-5exkA:
undetectable		 4yb6B-5exkA:
22.50
4yb6C-5exkA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 282
VAL A 283
GLU A 276
VAL A 244
LEU A 233
 None
 1.16A 4yb6C-5exkA:
undetectable
4yb6F-5exkA:
undetectable		 4yb6C-5exkA:
22.50
4yb6F-5exkA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 233
GLY A 282
VAL A 283
GLU A 276
VAL A 244
 None
 1.17A 4yb6A-5exkA:
undetectable
4yb6D-5exkA:
undetectable		 4yb6A-5exkA:
22.50
4yb6D-5exkA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 233
GLY A 282
VAL A 283
GLU A 276
VAL A 244
 None
 1.16A 4yb6D-5exkA:
undetectable
4yb6E-5exkA:
undetectable		 4yb6D-5exkA:
22.50
4yb6E-5exkA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 233
GLY A 282
VAL A 283
GLU A 276
VAL A 244
 None
 1.09A 4yb6B-5exkA:
undetectable
4yb6F-5exkA:
undetectable		 4yb6B-5exkA:
22.50
4yb6F-5exkA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 143
PHE A  74
SER A 109
ALA A 118
 None
 1.09A 5msdA-5exkA:
2.9		 5msdA-5exkA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 227
GLU A 228
LEU A 236
ALA A 232
LEU A 220
 None
 1.21A 5nd7B-5exkA:
3.4		 5nd7B-5exkA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5exk LIPOYL SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 227
PHE A 271
ARG A 261
 None
 1.11A 5yw0A-5exkA:
undetectable		 5yw0A-5exkA:
23.18