SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5exp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 5exp TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 327
LEU A 331
ILE A 153
ARG A 340
VAL A 182
 None
None
None
None
EDO  A 404 (-4.6A)
 1.25A 1hrkB-5expA:
3.0		 1hrkB-5expA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 5exp TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 174
SER A 176
ASP A 357
THR A 178
GLY A 177
 None
None
None
SO4  A 401 (-4.4A)
SO4  A 401 ( 3.4A)
 1.24A 2hmaA-5expA:
undetectable		 2hmaA-5expA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 5exp TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 328
PRO A 387
VAL A 383
GLY A 382
 None
 0.97A 2qd5A-5expA:
2.3		 2qd5A-5expA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 5exp TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 324
LEU A 327
LEU A 331
ASN A 361
VAL A 362
 None
None
None
None
EDO  A 404 (-4.2A)
 1.15A 3dcjA-5expA:
undetectable
3dcjB-5expA:
undetectable		 3dcjA-5expA:
25.75
3dcjB-5expA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 5exp TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		5 / 11 PHE A 299
LEU A 262
LEU A 259
LEU A 244
LEU A 171
 None
 0.88A 4dm8A-5expA:
undetectable		 4dm8A-5expA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5exp TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		3 / 3 MET A 159
GLN A 158
ARG A 157
 None
 1.12A 5ewzB-5expA:
undetectable		 5ewzB-5expA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 5exp TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 246
GLY A 174
SER A 176
GLY A 177
 None
None
None
SO4  A 401 ( 3.4A)
 1.08A 5kprA-5expA:
undetectable		 5kprA-5expA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5exp TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		3 / 3 MET A 159
GLN A 158
ARG A 157
 None
 1.11A 5m35B-5expA:
undetectable		 5m35B-5expA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 5exp TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		5 / 10 VAL A 280
LEU A 244
ARG A 233
GLY A 232
PHE A 234
 None
 1.07A 5mxbA-5expA:
undetectable		 5mxbA-5expA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5exp TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		3 / 3 MET A 159
GLN A 158
ARG A 157
 None
 1.12A 6fn9A-5expA:
undetectable		 6fn9A-5expA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5exp TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		3 / 3 MET A 159
GLN A 158
ARG A 157
 None
 1.13A 6fnaB-5expA:
undetectable		 6fnaB-5expA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5exp TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		3 / 3 MET A 159
GLN A 158
ARG A 157
 None
 1.12A 6fnbA-5expA:
undetectable		 6fnbA-5expA:
22.60