SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5exr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		3 / 3 GLN D 437
HIS D 431
PRO D 439
 None
 0.60A 1d8cA-5exrD:
2.0		 1d8cA-5exrD:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		5 / 12 LEU D 377
LEU D 420
VAL D 421
SER D 416
LEU D 574
 None
 1.25A 1db1A-5exrD:
undetectable		 1db1A-5exrD:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 MET C 776
ASP C 632
ARG C 688
MET C 689
 None
 1.10A 1dtlA-5exrC:
undetectable		 1dtlA-5exrC:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		4 / 8 LEU D 476
ARG D 427
PHE D 378
GLY D 379
 None
 1.02A 1fapB-5exrD:
undetectable		 1fapB-5exrD:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5exr DNA PRIMASE LARGE
SUBUNIT
(Homo
sapiens) 		3 / 3 GLN B 446
ILE B 276
HIS B 292
 None
 0.75A 1fm9A-5exrB:
undetectable		 1fm9A-5exrB:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
DNA PRIMASE LARGE
SUBUNIT
(Homo
sapiens) 		4 / 8 GLN B  27
LEU B  45
ARG B  49
LEU C1451
 None
 1.08A 1hk3A-5exrB:
2.7		 1hk3A-5exrB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 GLU C1350
LEU C1050
ALA C1056
LEU C1048
 None
 0.97A 1hwiB-5exrC:
4.8		 1hwiB-5exrC:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 GLU C1350
LEU C1050
ALA C1056
LEU C1048
 None
 0.97A 1hwiC-5exrC:
4.9		 1hwiC-5exrC:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5exr DNA PRIMASE LARGE
SUBUNIT
(Homo
sapiens) 		3 / 3 GLN B 446
ILE B 276
HIS B 292
 None
 0.75A 1k74A-5exrB:
undetectable		 1k74A-5exrB:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5exr DNA PRIMASE LARGE
SUBUNIT
(Homo
sapiens) 		4 / 8 HIS B 382
PHE B 365
LYS B 369
SER B 352
 None
 1.11A 1kb9A-5exrB:
undetectable
1kb9C-5exrB:
undetectable
1kb9D-5exrB:
undetectable
1kb9E-5exrB:
undetectable		 1kb9A-5exrB:
23.97
1kb9C-5exrB:
20.39
1kb9D-5exrB:
18.88
1kb9E-5exrB:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 GLY C1092
LEU C1087
ILE C1119
ILE C1112
HIS C1217
 None
 1.09A 1kyvA-5exrC:
undetectable
1kyvE-5exrC:
undetectable		 1kyvA-5exrC:
9.50
1kyvE-5exrC:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 ILE C1112
HIS C1217
GLY C1092
LEU C1087
ILE C1119
 None
 1.12A 1kyvB-5exrC:
undetectable
1kyvC-5exrC:
undetectable		 1kyvB-5exrC:
9.50
1kyvC-5exrC:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 ILE C1112
HIS C1217
GLY C1092
LEU C1087
ILE C1119
 None
 1.11A 1kyvC-5exrC:
undetectable
1kyvD-5exrC:
undetectable		 1kyvC-5exrC:
9.50
1kyvD-5exrC:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 ILE C1112
HIS C1217
GLY C1092
LEU C1087
ILE C1119
 None
 1.11A 1kyvD-5exrC:
undetectable
1kyvE-5exrC:
undetectable		 1kyvD-5exrC:
9.50
1kyvE-5exrC:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA8_0
(GRAMICIDIN A)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 4 GLY C 363
VAL C 365
TRP C 345
TRP C 498
 None
 1.50A 1nrmA-5exrC:
undetectable		 1nrmA-5exrC:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA8_0
(GRAMICIDIN A)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 4 GLY C 363
VAL C 365
TRP C 345
TRP C 498
 None
 1.41A 1nt5A-5exrC:
undetectable		 1nt5A-5exrC:
1.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB8_0
(GRAMICIDIN A)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 4 GLY C 363
VAL C 365
TRP C 345
TRP C 498
 None
 1.41A 1nt5B-5exrC:
undetectable		 1nt5B-5exrC:
1.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 PHE C 542
LEU C 563
ALA C 749
LEU C 647
PHE C 622
 None
 1.16A 1og5A-5exrC:
undetectable		 1og5A-5exrC:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 PHE C 542
LEU C 563
ALA C 749
LEU C 647
PHE C 622
 None
 1.16A 1og5B-5exrC:
undetectable		 1og5B-5exrC:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 LEU C1212
ILE C1216
VAL C1220
PHE C1133
ARG C1115
 None
 1.18A 1wsvA-5exrC:
undetectable		 1wsvA-5exrC:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 GLY C1240
THR C1237
ALA C1236
VAL C1248
 None
 0.86A 2a1hA-5exrC:
undetectable
2a1hB-5exrC:
undetectable		 2a1hA-5exrC:
16.01
2a1hB-5exrC:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 5exr DNA PRIMASE LARGE
SUBUNIT
(Homo
sapiens) 		4 / 7 SER B 352
LEU B 311
GLY B 315
ILE B 276
 None
 1.12A 2bdmA-5exrB:
undetectable		 2bdmA-5exrB:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 11 PHE C 861
ILE C 983
THR C1003
VAL C1029
TYR C1033
 None
 1.35A 2gl0B-5exrC:
undetectable
2gl0C-5exrC:
undetectable		 2gl0B-5exrC:
10.41
2gl0C-5exrC:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 PHE C 861
ILE C 983
THR C1003
VAL C1029
TYR C1033
 None
 1.41A 2gl0D-5exrC:
undetectable
2gl0E-5exrC:
undetectable		 2gl0D-5exrC:
10.41
2gl0E-5exrC:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 11 PHE C 861
ILE C 983
THR C1003
VAL C1029
TYR C1033
 None
 1.35A 2gl0E-5exrC:
undetectable
2gl0F-5exrC:
1.3		 2gl0E-5exrC:
10.41
2gl0F-5exrC:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		4 / 6 ASN C 549
HIS C 553
ILE C 728
THR D 309
 None
 1.04A 2hkkA-5exrC:
undetectable		 2hkkA-5exrC:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		4 / 7 SER D 418
SER D 415
THR D 413
ASN D 368
 None
 1.05A 2i91A-5exrD:
undetectable		 2i91A-5exrD:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		4 / 7 SER D 418
SER D 415
THR D 413
ASN D 368
 None
 1.04A 2i91B-5exrD:
2.1		 2i91B-5exrD:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 6 ILE C 629
ARG C 664
ILE C 662
PHE C 622
 None
 0.97A 2q72A-5exrC:
undetectable		 2q72A-5exrC:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 6 ILE C1006
LEU C 858
LEU C 984
ASP C1004
 None
 1.00A 2rlfA-5exrC:
undetectable
2rlfD-5exrC:
undetectable		 2rlfA-5exrC:
3.55
2rlfD-5exrC:
3.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		5 / 9 ILE D 367
ILE D 409
PHE D 422
ILE D 598
VAL D 389
 None
 1.28A 2ygpA-5exrD:
undetectable		 2ygpA-5exrD:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 HIS C 794
ASN C 774
ILE C 775
TRP C 345
 None
 1.40A 3ccfB-5exrC:
undetectable		 3ccfB-5exrC:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		5 / 12 ARG D 545
GLU D 169
ARG D 597
ASN D 166
TYR D 546
 None
 1.27A 3ckzA-5exrD:
undetectable		 3ckzA-5exrD:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 PHE C 583
VAL C 585
ALA C 612
THR C 745
ILE C 557
 None
 1.30A 3dl9B-5exrC:
undetectable		 3dl9B-5exrC:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 10 ILE C 662
PHE C 622
LEU C 623
ALA C 624
ILE C 639
 None
 1.02A 3falC-5exrC:
undetectable		 3falC-5exrC:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		3 / 3 GLU D 218
VAL D 219
CYH D 222
 None
 1.02A 3fbxA-5exrD:
undetectable		 3fbxA-5exrD:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 11 ILE C 662
PHE C 622
LEU C 623
ALA C 624
ILE C 639
 None
 0.95A 3fc6A-5exrC:
undetectable		 3fc6A-5exrC:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 VAL C 340
VAL C 378
PHE C 343
HIS C 342
 None
 1.04A 3fhxB-5exrC:
undetectable		 3fhxB-5exrC:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5exr DNA PRIMASE LARGE
SUBUNIT
(Homo
sapiens) 		3 / 3 ASN B 374
MET B 288
PHE B 365
 None
 1.02A 3g4lD-5exrB:
undetectable		 3g4lD-5exrB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		5 / 12 GLY D 255
LEU D 296
VAL D 270
LEU D 231
TYR D 235
 None
 1.16A 3g9eA-5exrD:
undetectable		 3g9eA-5exrD:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		5 / 12 LEU D 394
ILE D 401
CYH D 405
LEU D 382
ASP D 358
 None
 1.20A 3ko0A-5exrD:
undetectable
3ko0B-5exrD:
undetectable
3ko0C-5exrD:
undetectable
3ko0D-5exrD:
undetectable		 3ko0A-5exrD:
13.78
3ko0B-5exrD:
13.78
3ko0C-5exrD:
13.78
3ko0D-5exrD:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		5 / 11 ASP D 358
LEU D 382
LEU D 394
ILE D 401
CYH D 405
 None
 1.20A 3ko0A-5exrD:
undetectable
3ko0B-5exrD:
undetectable
3ko0I-5exrD:
undetectable
3ko0J-5exrD:
undetectable		 3ko0A-5exrD:
13.78
3ko0B-5exrD:
13.78
3ko0I-5exrD:
13.78
3ko0J-5exrD:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		5 / 12 LEU D 394
ILE D 401
CYH D 405
LEU D 382
ASP D 358
 None
 1.23A 3ko0K-5exrD:
undetectable
3ko0L-5exrD:
undetectable
3ko0S-5exrD:
undetectable
3ko0T-5exrD:
undetectable		 3ko0K-5exrD:
13.78
3ko0L-5exrD:
13.78
3ko0S-5exrD:
13.78
3ko0T-5exrD:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		5 / 12 LEU D 382
LEU D 394
ILE D 401
CYH D 405
ASP D 358
 None
 1.19A 3ko0K-5exrD:
undetectable
3ko0L-5exrD:
undetectable
3ko0M-5exrD:
undetectable
3ko0N-5exrD:
undetectable		 3ko0K-5exrD:
13.78
3ko0L-5exrD:
13.78
3ko0M-5exrD:
13.78
3ko0N-5exrD:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		5 / 12 ASP D 358
LEU D 382
LEU D 394
ILE D 401
CYH D 405
 None
 1.18A 3ko0M-5exrD:
undetectable
3ko0N-5exrD:
undetectable
3ko0O-5exrD:
undetectable
3ko0P-5exrD:
undetectable		 3ko0M-5exrD:
13.78
3ko0N-5exrD:
13.78
3ko0O-5exrD:
13.78
3ko0P-5exrD:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		5 / 12 LEU D 377
LEU D 420
VAL D 421
SER D 416
LEU D 574
 None
 1.26A 3m7rA-5exrD:
undetectable		 3m7rA-5exrD:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		4 / 7 PRO D 359
TYR D 357
THR D 356
ILE D 355
 None
 0.81A 3p50A-5exrD:
undetectable		 3p50A-5exrD:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		4 / 7 PRO D 359
TYR D 357
THR D 356
ILE D 355
 None
 0.80A 3p50B-5exrD:
undetectable		 3p50B-5exrD:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		4 / 7 PRO D 359
TYR D 357
THR D 356
ILE D 355
 None
 0.81A 3p50C-5exrD:
undetectable		 3p50C-5exrD:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		4 / 7 PRO D 359
TYR D 357
THR D 356
ILE D 355
 None
 0.79A 3p50D-5exrD:
undetectable		 3p50D-5exrD:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		4 / 7 PRO D 359
TYR D 357
THR D 356
ILE D 355
 None
 0.82A 3p50E-5exrD:
undetectable		 3p50E-5exrD:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		4 / 5 CYH D 346
PRO D 424
THR D 472
THR D 563
 None
 1.50A 3q07B-5exrD:
undetectable		 3q07B-5exrD:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		4 / 7 VAL D 302
LEU D 272
PHE D 297
LEU D 265
 None
 1.05A 3qeoB-5exrD:
undetectable		 3qeoB-5exrD:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 10 ARG C1222
VAL C1220
ILE C1216
GLN C1215
ILE C1079
 None
 1.36A 3retA-5exrC:
1.4
3retB-5exrC:
1.0		 3retA-5exrC:
7.75
3retB-5exrC:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5exr DNA PRIMASE LARGE
SUBUNIT
(Homo
sapiens) 		4 / 7 THR B 363
HIS B 443
ASN B 445
TYR B 362
 None
 1.41A 4a3uA-5exrB:
undetectable		 4a3uA-5exrB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5exr DNA PRIMASE LARGE
SUBUNIT
(Homo
sapiens) 		4 / 7 THR B 363
HIS B 443
ASN B 445
TYR B 362
 None
 1.45A 4a3uB-5exrB:
undetectable		 4a3uB-5exrB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLU C 615
ILE C 558
VAL C 653
GLN D 248
PHE C 642
 None
 1.25A 4fglA-5exrC:
undetectable
4fglB-5exrC:
undetectable		 4fglA-5exrC:
12.21
4fglB-5exrC:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 ILE C 944
ALA C 765
MET C 776
LEU C 570
LYS C 572
 None
 1.29A 4gh8B-5exrC:
undetectable		 4gh8B-5exrC:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
DNA PRIMASE LARGE
SUBUNIT
(Homo
sapiens) 		4 / 4 LEU B 108
LEU C1451
GLN B 247
GLU B  43
 None
 1.00A 4i41A-5exrB:
undetectable		 4i41A-5exrB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 LEU C 708
VAL C 712
ILE C 755
ILE C 752
ALA C 541
 None
 0.98A 4ltwA-5exrC:
undetectable		 4ltwA-5exrC:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 ILE C 771
ALA C 953
GLN C 946
LEU C 764
ILE C 768
 None
 1.05A 4m2xC-5exrC:
undetectable		 4m2xC-5exrC:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		3 / 3 SER D 205
ASP D 521
ASP D 215
 None
 0.82A 4mwzA-5exrD:
undetectable		 4mwzA-5exrD:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		4 / 7 PHE D 525
TYR D 435
ILE D 502
LEU D 531
 None
 1.08A 4uymB-5exrD:
undetectable		 4uymB-5exrD:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		4 / 8 ARG D 578
PHE D 327
VAL D 467
ASP D 536
 None
 1.10A 4xqgA-5exrD:
undetectable		 4xqgA-5exrD:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		4 / 8 ARG D 578
PHE D 327
VAL D 467
ASP D 536
 None
 1.10A 4xqgB-5exrD:
undetectable		 4xqgB-5exrD:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 6 ILE C 868
PHE C 872
ILE C 983
GLU C 982
 None
 1.09A 4zzcA-5exrC:
undetectable
4zzcB-5exrC:
undetectable		 4zzcA-5exrC:
15.25
4zzcB-5exrC:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 6 ILE C 868
PHE C 872
ILE C 983
GLU C 982
 None
 1.10A 4zzcB-5exrC:
undetectable
4zzcC-5exrC:
undetectable		 4zzcB-5exrC:
15.25
4zzcC-5exrC:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 5exr DNA PRIMASE LARGE
SUBUNIT
(Homo
sapiens) 		4 / 6 ILE B 186
PHE B 151
ILE B 217
GLU B 221
 None
 1.07A 4zzcB-5exrB:
2.2
4zzcC-5exrB:
2.1		 4zzcB-5exrB:
21.36
4zzcC-5exrB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 LEU C 911
PHE C 441
ILE C 910
 None
 0.74A 5dzk1-5exrC:
undetectable
5dzkF-5exrC:
undetectable
5dzkM-5exrC:
undetectable		 5dzk1-5exrC:
1.16
5dzkF-5exrC:
12.36
5dzkM-5exrC:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		3 / 3 LEU D 420
PHE D 455
ILE D 410
 None
 0.73A 5dzk1-5exrD:
undetectable
5dzkF-5exrD:
1.9
5dzkM-5exrD:
undetectable		 5dzk1-5exrD:
1.83
5dzkF-5exrD:
16.44
5dzkM-5exrD:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 4 LEU C 537
ILE C 633
PRO C 763
LEU C 766
 None
 1.21A 5eb3A-5exrC:
undetectable		 5eb3A-5exrC:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 TYR C 797
PHE C 417
ILE C 427
TYR C 457
PHE C 389
 None
 1.31A 5esgA-5exrC:
undetectable		 5esgA-5exrC:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		3 / 3 MET D 341
GLN D 339
ARG D 185
 None
 0.93A 5ewzB-5exrD:
undetectable		 5ewzB-5exrD:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 5exr DNA PRIMASE LARGE
SUBUNIT
(Homo
sapiens) 		3 / 3 ASP B 436
SER B  62
TYR B  63
 None
 0.59A 5glmA-5exrB:
undetectable		 5glmA-5exrB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		4 / 6 LEU D 477
THR D 472
GLN D 437
MET D 518
 None
 1.28A 5h8tA-5exrD:
undetectable		 5h8tA-5exrD:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5exr DNA PRIMASE LARGE
SUBUNIT
(Homo
sapiens) 		5 / 12 ASP B 361
ILE B 349
GLY B 310
LEU B 313
GLY B 344
 None
 1.17A 5i71A-5exrB:
undetectable		 5i71A-5exrB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5exr DNA PRIMASE LARGE
SUBUNIT
(Homo
sapiens) 		5 / 12 ASP B 361
ILE B 349
GLY B 310
LEU B 313
GLY B 344
 None
 1.18A 5i75A-5exrB:
undetectable		 5i75A-5exrB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 9 ILE C 639
LEU C 644
THR C 685
ARG C 664
ILE C 662
 None
 1.35A 5ifuB-5exrC:
undetectable		 5ifuB-5exrC:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		3 / 3 MET D 341
GLN D 339
ARG D 185
 None
 0.91A 5m35B-5exrD:
undetectable		 5m35B-5exrD:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		3 / 3 MET D 341
GLN D 339
ARG D 185
 None
 0.90A 5m36A-5exrD:
undetectable		 5m36A-5exrD:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		5 / 12 ILE D 539
LEU D 462
PHE D 378
LEU D 499
LEU D 477
 None
 1.30A 5tiwA-5exrD:
undetectable		 5tiwA-5exrD:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		5 / 12 GLU D 543
GLY D 565
VAL D 171
GLY D 560
ARG D 427
 None
 1.06A 5vooE-5exrD:
2.3		 5vooE-5exrD:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		4 / 6 HIS D 431
VAL D 456
LEU D 202
GLN D 454
 None
 1.27A 5xdhA-5exrD:
undetectable
5xdhC-5exrD:
undetectable		 5xdhA-5exrD:
9.08
5xdhC-5exrD:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		4 / 6 GLN D 454
HIS D 431
VAL D 456
LEU D 202
 None
 1.27A 5xdhA-5exrD:
undetectable
5xdhC-5exrD:
undetectable		 5xdhA-5exrD:
9.08
5xdhC-5exrD:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5exr DNA PRIMASE LARGE
SUBUNIT
(Homo
sapiens) 		3 / 3 GLN B 446
ILE B 276
HIS B 292
 None
 0.68A 5z12B-5exrB:
undetectable		 5z12B-5exrB:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 TYR C 349
ARG C 682
THR C 685
 None
 1.04A 5z84J-5exrC:
undetectable		 5z84J-5exrC:
4.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		4 / 8 LEU D 377
PHE D 422
ARG D 407
LEU D 360
 None
 0.80A 5zcoA-5exrD:
undetectable
5zcoJ-5exrD:
undetectable		 5zcoA-5exrD:
21.16
5zcoJ-5exrD:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		5 / 10 ALA D 529
TYR D 509
PRO D 514
GLU D 516
VAL D 219
 None
 1.29A 6b89A-5exrD:
undetectable		 6b89A-5exrD:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		5 / 10 VAL D 557
LEU D 538
LEU D 576
GLY D 560
VAL D 593
 None
 1.19A 6eu9B-5exrD:
undetectable		 6eu9B-5exrD:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		3 / 3 MET D 341
GLN D 339
ARG D 185
 None
 0.90A 6fn9A-5exrD:
undetectable		 6fn9A-5exrD:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens;
Homo
sapiens) 		4 / 4 ILE D 520
MET D 518
GLN D 515
ARG C1358
 None
 1.32A 6fn9B-5exrD:
0.0		 6fn9B-5exrD:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		3 / 3 MET D 341
GLN D 339
ARG D 185
 None
 0.94A 6fnaB-5exrD:
undetectable		 6fnaB-5exrD:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens;
Homo
sapiens) 		3 / 3 MET D 518
GLN D 515
ARG C1358
 None
 1.15A 6fnaB-5exrD:
undetectable		 6fnaB-5exrD:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		3 / 3 MET D 341
GLN D 339
ARG D 185
 None
 0.91A 6fnbA-5exrD:
undetectable		 6fnbA-5exrD:
16.92