SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5exv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5exv HEMIN-DEGRADING
HEMS.CHUX DOMAIN
PROTEIN
(Vibrio
cholerae) 		4 / 5 THR A 131
ILE A 109
GLU A 107
PHE A 138
 None
 1.47A 4acaC-5exvA:
undetectable		 4acaC-5exvA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 5exv HEMIN-DEGRADING
HEMS.CHUX DOMAIN
PROTEIN
(Vibrio
cholerae) 		4 / 5 ASP A  33
HIS A  36
GLY A 134
ALA A 132
 None
 0.97A 5hwaA-5exvA:
undetectable		 5hwaA-5exvA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5exv HEMIN-DEGRADING
HEMS.CHUX DOMAIN
PROTEIN
(Vibrio
cholerae) 		3 / 3 LEU A  19
TYR A 141
SER A 124
 None
 0.77A 5iktA-5exvA:
undetectable		 5iktA-5exvA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 5exv HEMIN-DEGRADING
HEMS.CHUX DOMAIN
PROTEIN
(Vibrio
cholerae) 		3 / 3 ARG A 122
PHE A 119
GLY A 121
 None
 0.77A 6fgdA-5exvA:
undetectable		 6fgdA-5exvA:
18.23