SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5exx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5exx TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 185
GLU A 181
SER A 333
 None
None
C2E  A 502 (-2.4A)
 0.92A 2xctD-5exxA:
undetectable		 2xctD-5exxA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5exx TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		3 / 3 PRO A 251
LEU A 252
GLN A 255
 None
 0.72A 3hznG-5exxA:
undetectable
3hznH-5exxA:
undetectable		 3hznG-5exxA:
23.48
3hznH-5exxA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5exx TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 376
LEU A 368
ALA A 349
SER A 352
LEU A 353
 None
 1.02A 3ln1A-5exxA:
undetectable		 3ln1A-5exxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5exx TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 376
LEU A 368
ALA A 349
SER A 352
LEU A 353
 None
 1.00A 3ln1B-5exxA:
undetectable		 3ln1B-5exxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5exx TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 376
LEU A 368
ALA A 349
SER A 352
LEU A 353
 None
 1.02A 3ln1C-5exxA:
undetectable		 3ln1C-5exxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5exx TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 376
LEU A 368
ALA A 349
SER A 352
LEU A 353
 None
 1.02A 3n8xB-5exxA:
undetectable		 3n8xB-5exxA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5exx TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 306
ARG A 265
ASP A 167
 None
 1.00A 3wipG-5exxA:
undetectable
3wipH-5exxA:
undetectable		 3wipG-5exxA:
18.40
3wipH-5exxA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5exx TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 376
LEU A 368
ALA A 349
SER A 352
LEU A 353
 None
 1.01A 5jw1A-5exxA:
undetectable		 5jw1A-5exxA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJD_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5exx TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 303
LEU A 252
ILE A 206
ILE A 247
LEU A 215
 None
 1.07A 5ljdA-5exxA:
undetectable		 5ljdA-5exxA:
17.20