SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ey0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 5ey0 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Staphylococcus
aureus) 		5 / 12 LEU B 179
LYS B 223
ILE B 190
LEU B 221
ILE B 230
 None
 0.93A 2d0kA-5ey0B:
undetectable		 2d0kA-5ey0B:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 5ey0 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Staphylococcus
aureus) 		5 / 12 LEU B 224
VAL B 229
GLY B 228
LEU B 179
ALA B 175
 None
 0.94A 2egvA-5ey0B:
undetectable		 2egvA-5ey0B:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 5ey0 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Staphylococcus
aureus) 		5 / 12 LEU B 224
VAL B 229
GLY B 228
LEU B 179
ALA B 175
 None
 0.96A 2egvB-5ey0B:
undetectable		 2egvB-5ey0B:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 5ey0 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Staphylococcus
aureus) 		4 / 6 ASP B 133
ARG B 130
THR B  37
ASP B 139
 None
 1.08A 2j2pE-5ey0B:
undetectable
2j2pF-5ey0B:
undetectable		 2j2pE-5ey0B:
20.67
2j2pF-5ey0B:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 5ey0 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Staphylococcus
aureus) 		5 / 10 LEU B 224
VAL B 229
GLY B 228
LEU B 179
ALA B 175
 None
 0.93A 2v3kA-5ey0B:
undetectable		 2v3kA-5ey0B:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 5ey0 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Staphylococcus
aureus) 		5 / 12 VAL B  42
LEU B 126
THR B 125
THR B  35
ASN B  38
 None
 0.95A 3a35A-5ey0B:
undetectable		 3a35A-5ey0B:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 5ey0 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Staphylococcus
aureus) 		5 / 12 VAL B  42
LEU B 126
THR B 125
THR B  35
ASN B  38
 None
 1.01A 3a35B-5ey0B:
undetectable		 3a35B-5ey0B:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 5ey0 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Staphylococcus
aureus) 		5 / 12 VAL B  42
LEU B 126
THR B 125
THR B  35
ASN B  38
 None
 0.98A 3a3bA-5ey0B:
undetectable		 3a3bA-5ey0B:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5ey0 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Staphylococcus
aureus) 		4 / 6 LEU B 179
TYR B 181
LEU B 253
GLU B 188
 None
 1.18A 4f3tA-5ey0B:
undetectable		 4f3tA-5ey0B:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD305_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5ey0 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Staphylococcus
aureus) 		4 / 4 ILE B  62
LEU B  57
LYS B  58
ASN B  38
 None
 1.03A 4g19D-5ey0B:
undetectable		 4g19D-5ey0B:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5ey0 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Staphylococcus
aureus) 		5 / 11 ALA B 227
LEU B 224
GLU B 183
LYS B 184
LEU B 253
 None
 0.92A 4wg0C-5ey0B:
undetectable
4wg0D-5ey0B:
undetectable
4wg0E-5ey0B:
undetectable		 4wg0C-5ey0B:
4.01
4wg0D-5ey0B:
4.01
4wg0E-5ey0B:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5ey0 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Staphylococcus
aureus) 		5 / 11 ALA B 227
LEU B 224
GLU B 183
LYS B 184
LEU B 253
 None
 0.95A 4wg0E-5ey0B:
undetectable
4wg0F-5ey0B:
undetectable
4wg0G-5ey0B:
undetectable		 4wg0E-5ey0B:
4.01
4wg0F-5ey0B:
4.01
4wg0G-5ey0B:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 5ey0 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Staphylococcus
aureus) 		5 / 9 LEU B  14
THR B  35
VAL B  39
VAL B  27
LEU B 128
 None
 1.43A 4wnvA-5ey0B:
undetectable		 4wnvA-5ey0B:
22.00