SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ey5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 12 PHE B 238
PRO B 240
PHE B 241
PRO B 221
GLN B 212
 None
 1.30A 1fm4A-5ey5B:
undetectable		 1fm4A-5ey5B:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 5ey5 LBCA-B
(synthetic
construct) 		4 / 8 GLU B  75
ASN B  78
LEU B  45
LEU B  41
 None
 0.94A 1hwiB-5ey5B:
undetectable		 1hwiB-5ey5B:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 5ey5 LBCA-B
(synthetic
construct) 		4 / 8 GLU B  75
ASN B  78
LEU B  45
LEU B  41
 None
 0.97A 1hwiC-5ey5B:
undetectable		 1hwiC-5ey5B:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 11 VAL B 322
TYR B 354
GLU B 253
GLY B 229
LEU B 301
 None
None
None
PLP  B 501 ( 3.4A)
PLP  B 501 ( 4.9A)
 1.18A 1i9jH-5ey5B:
undetectable
1i9jL-5ey5B:
undetectable		 1i9jH-5ey5B:
20.33
1i9jL-5ey5B:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5ey5 LBCA-B
(synthetic
construct) 		4 / 8 ASP B 302
ASP B 135
GLY B 110
THR B 382
 None
 0.88A 1m4iA-5ey5B:
undetectable		 1m4iA-5ey5B:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5ey5 LBCATS-A
(synthetic
construct) 		4 / 7 ARG A 261
ALA A  45
ILE A 236
PRO A  21
 None
 1.10A 1oniA-5ey5A:
undetectable
1oniB-5ey5A:
undetectable		 1oniA-5ey5A:
22.75
1oniB-5ey5A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5ey5 LBCATS-A
(synthetic
construct) 		4 / 7 ILE A 236
PRO A  21
ARG A 261
ALA A  45
 None
 1.10A 1oniD-5ey5A:
undetectable
1oniE-5ey5A:
undetectable		 1oniD-5ey5A:
22.75
1oniE-5ey5A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5ey5 LBCATS-A
(synthetic
construct) 		4 / 7 ILE A 236
PRO A  21
ARG A 261
ALA A  45
 None
 1.08A 1oniG-5ey5A:
undetectable
1oniI-5ey5A:
undetectable		 1oniG-5ey5A:
22.75
1oniI-5ey5A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5ey5 LBCA-B
LBCATS-A
(synthetic
construct) 		4 / 8 THR B  16
TRP B 174
LEU A  58
MET B 171
 None
 1.11A 1uw6P-5ey5B:
undetectable
1uw6Q-5ey5B:
undetectable		 1uw6P-5ey5B:
20.51
1uw6Q-5ey5B:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5ey5 LBCA-B
LBCATS-A
(synthetic
construct) 		4 / 8 TRP B 174
LEU A  58
MET B 171
THR B  16
 None
 1.13A 1uw6P-5ey5B:
undetectable
1uw6T-5ey5B:
undetectable		 1uw6P-5ey5B:
20.51
1uw6T-5ey5B:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ey5 LBCA-B
(synthetic
construct) 		4 / 5 ILE B 259
LEU B 284
ALA B 265
GLU B 253
 None
 1.27A 1xvaA-5ey5B:
2.6
1xvaB-5ey5B:
2.6		 1xvaA-5ey5B:
23.50
1xvaB-5ey5B:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 5ey5 LBCA-B
LBCATS-A
(synthetic
construct) 		5 / 12 GLY B 289
GLN B 285
VAL B 275
THR A 101
ILE A  52
 None
 1.36A 1z95A-5ey5B:
undetectable		 1z95A-5ey5B:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 12 GLY B 341
ASN B  60
LEU B  61
GLY B 376
PHE B 333
 None
 1.15A 2f8lA-5ey5B:
2.1		 2f8lA-5ey5B:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 5ey5 LBCATS-A
(synthetic
construct) 		5 / 9 THR A  33
THR A  24
ALA A  25
LEU A  78
THR A  76
 None
 1.25A 2npnA-5ey5A:
undetectable		 2npnA-5ey5A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 5ey5 LBCA-B
(synthetic
construct) 		4 / 8 TYR B 354
SER B 373
LEU B 313
THR B  53
 None
PLP  B 501 (-2.4A)
None
None
 1.16A 2v0zO-5ey5B:
undetectable		 2v0zO-5ey5B:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 12 GLY B 113
ILE B  85
ASN B  78
ALA B  82
GLU B 106
 None
None
None
PLP  B 501 ( 3.1A)
None
 1.17A 2vdvE-5ey5B:
undetectable		 2vdvE-5ey5B:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 11 GLY B 113
ILE B  85
ASN B  78
ALA B  82
GLU B 106
 None
None
None
PLP  B 501 ( 3.1A)
None
 1.17A 2vdvF-5ey5B:
undetectable		 2vdvF-5ey5B:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 12 THR B 107
ILE B 184
GLY B 113
VAL B 143
VAL B 128
 None
 1.09A 2yvlA-5ey5B:
undetectable		 2yvlA-5ey5B:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 12 THR B 107
ILE B 184
GLY B 113
VAL B 143
VAL B 128
 None
 1.12A 2yvlB-5ey5B:
2.0		 2yvlB-5ey5B:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 12 THR B 107
ILE B 184
GLY B 113
VAL B 143
VAL B 128
 None
 1.12A 2yvlC-5ey5B:
2.3		 2yvlC-5ey5B:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 12 THR B 107
ILE B 184
GLY B 113
VAL B 143
VAL B 128
 None
 1.12A 2yvlD-5ey5B:
2.2		 2yvlD-5ey5B:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5ey5 LBCA-B
(synthetic
construct) 		3 / 3 THR B 382
SER B 296
LYS B 257
 None
 1.15A 3aocC-5ey5B:
undetectable		 3aocC-5ey5B:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5ey5 LBCATS-A
(synthetic
construct) 		4 / 7 PHE A 114
PHE A  82
LYS A  80
GLY A  75
 None
 0.89A 3em0B-5ey5A:
undetectable		 3em0B-5ey5A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 10 GLY B 278
GLN B  11
VAL B  13
ILE B 167
VAL B 189
 None
 1.20A 3fhjA-5ey5B:
undetectable		 3fhjA-5ey5B:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 9 GLY B 278
GLN B  11
VAL B  13
ILE B 167
VAL B 189
 None
 1.20A 3fi0A-5ey5B:
undetectable		 3fi0A-5ey5B:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 9 GLY B 278
GLN B  11
VAL B  13
ILE B 167
VAL B 189
 None
 1.17A 3fi0K-5ey5B:
undetectable		 3fi0K-5ey5B:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 9 GLY B 278
GLN B  11
VAL B  13
ILE B 167
VAL B 189
 None
 1.21A 3fi0M-5ey5B:
undetectable		 3fi0M-5ey5B:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5ey5 LBCA-B
(synthetic
construct) 		4 / 6 ILE B 368
VAL B 370
LEU B  72
LEU B  61
 None
 0.90A 3kp6A-5ey5B:
undetectable
3kp6B-5ey5B:
undetectable		 3kp6A-5ey5B:
18.01
3kp6B-5ey5B:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5ey5 LBCATS-A
(synthetic
construct) 		5 / 12 GLY A  26
ASP A  29
GLY A  51
GLY A  75
ILE A  52
 None
 1.18A 3ku1G-5ey5A:
undetectable		 3ku1G-5ey5A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 12 LYS B  84
GLY B 108
ALA B 109
ASP B 165
ALA B 166
 PLP  B 501 (-1.4A)
None
None
None
None
 1.26A 3nmuA-5ey5B:
undetectable
3nmuF-5ey5B:
undetectable		 3nmuA-5ey5B:
22.37
3nmuF-5ey5B:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 5ey5 LBCATS-A
(synthetic
construct) 		5 / 9 GLY A  44
ALA A  45
ASP A  46
ILE A  47
LEU A  40
 None
 0.77A 3ogpA-5ey5A:
undetectable		 3ogpA-5ey5A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 5ey5 LBCATS-A
(synthetic
construct) 		5 / 9 GLY A  44
ALA A  45
ASP A  46
ILE A  47
LEU A  40
 None
 0.82A 3ogpB-5ey5A:
undetectable		 3ogpB-5ey5A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 5ey5 LBCATS-A
(synthetic
construct) 		5 / 12 GLY A  44
ALA A  45
ASP A  46
ILE A  47
LEU A  40
 None
 0.81A 3ogqB-5ey5A:
undetectable		 3ogqB-5ey5A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 5ey5 LBCA-B
LBCATS-A
(synthetic
construct) 		4 / 7 ASP B 286
ASP B 288
TYR A 109
ARG A 113
 None
 1.29A 3s3oA-5ey5B:
undetectable		 3s3oA-5ey5B:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5ey5 LBCA-B
(synthetic
construct) 		3 / 3 ARG B  30
MET B  98
ARG B  97
 None
 1.49A 3uvvA-5ey5B:
undetectable		 3uvvA-5ey5B:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5ey5 LBCATS-A
(synthetic
construct) 		5 / 12 VAL A  81
LEU A  34
ILE A  48
LEU A  40
VAL A 253
 None
 1.15A 3w68A-5ey5A:
2.5		 3w68A-5ey5A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5ey5 LBCATS-A
(synthetic
construct) 		5 / 12 VAL A  81
LEU A  34
ILE A  48
LEU A  40
VAL A 253
 None
 1.07A 3w68B-5ey5A:
1.8		 3w68B-5ey5A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 5ey5 LBCA-B
(synthetic
construct) 		4 / 6 ALA B 234
GLY B 307
PRO B 308
VAL B 188
 None
 0.85A 4dubA-5ey5B:
1.4		 4dubA-5ey5B:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ID5_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 12 LEU B 313
VAL B 188
VAL B 228
PRO B 195
PRO B 308
 None
None
PLP  B 501 ( 4.6A)
None
None
 1.46A 4id5A-5ey5B:
undetectable		 4id5A-5ey5B:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFV_A_T27A601_1
(EXORIBONUCLEASE H,
P66 RT)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 12 LEU B 313
VAL B 188
VAL B 228
PRO B 195
PRO B 308
 None
None
PLP  B 501 ( 4.6A)
None
None
 1.43A 4ifvA-5ey5B:
undetectable		 4ifvA-5ey5B:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG3_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 12 LEU B 313
VAL B 188
VAL B 228
PRO B 195
PRO B 308
 None
None
PLP  B 501 ( 4.6A)
None
None
 1.43A 4ig3A-5ey5B:
undetectable		 4ig3A-5ey5B:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5ey5 LBCATS-A
(synthetic
construct) 		5 / 11 ALA A  67
ALA A  71
THR A  76
VAL A  81
LEU A  50
 None
 1.07A 4j6cA-5ey5A:
undetectable		 4j6cA-5ey5A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5ey5 LBCATS-A
(synthetic
construct) 		5 / 10 ALA A  67
ALA A  71
THR A  76
VAL A  81
LEU A  50
 None
 1.07A 4j6cB-5ey5A:
undetectable		 4j6cB-5ey5A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5ey5 LBCATS-A
(synthetic
construct) 		5 / 12 ALA A  67
ALA A  71
THR A  76
VAL A  81
LEU A  50
 None
 1.09A 4j6dA-5ey5A:
undetectable		 4j6dA-5ey5A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5ey5 LBCATS-A
(synthetic
construct) 		5 / 12 ALA A  67
ALA A  71
THR A  76
VAL A  81
LEU A  50
 None
 1.08A 4j6dB-5ey5A:
undetectable		 4j6dB-5ey5A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5ey5 LBCATS-A
(synthetic
construct) 		5 / 12 ALA A  67
ALA A  71
THR A  76
VAL A  81
LEU A  50
 None
 1.09A 4jbtA-5ey5A:
undetectable		 4jbtA-5ey5A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5ey5 LBCATS-A
(synthetic
construct) 		5 / 11 ALA A  67
ALA A  71
THR A  76
VAL A  81
LEU A  50
 None
 1.08A 4jbtB-5ey5A:
undetectable		 4jbtB-5ey5A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 5ey5 LBCATS-A
(synthetic
construct) 		5 / 12 ALA A 155
GLY A 181
GLU A  49
GLY A 211
PHE A 212
 None
None
G3P  A 301 (-3.1A)
G3P  A 301 ( 4.8A)
G3P  A 301 (-4.6A)
 1.11A 4r29B-5ey5A:
undetectable		 4r29B-5ey5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 12 GLY B 376
THR B 382
ASP B 377
ILE B 342
LEU B 346
 None
 1.17A 5bw4A-5ey5B:
undetectable		 5bw4A-5ey5B:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5ey5 LBCA-B
(synthetic
construct) 		4 / 7 ALA B 166
GLY B 132
SER B 160
GLY B 159
 None
 0.89A 5e26A-5ey5B:
undetectable
5e26B-5ey5B:
undetectable		 5e26A-5ey5B:
21.41
5e26B-5ey5B:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 5ey5 LBCA-B
(synthetic
construct) 		4 / 6 GLY B 230
SER B 187
VAL B 188
HIS B  83
 PLP  B 501 (-4.0A)
PLP  B 501 (-2.7A)
None
PLP  B 501 (-4.0A)
 1.12A 5ewuA-5ey5B:
2.4		 5ewuA-5ey5B:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 5ey5 LBCA-B
(synthetic
construct) 		4 / 6 GLY B 230
SER B 187
VAL B 188
HIS B  83
 PLP  B 501 (-4.0A)
PLP  B 501 (-2.7A)
None
PLP  B 501 (-4.0A)
 1.12A 5ewuB-5ey5B:
2.7		 5ewuB-5ey5B:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 5ey5 LBCATS-A
(synthetic
construct) 		4 / 6 ILE A  52
PHE A  54
PHE A  22
THR A 183
 None
None
G3P  A 301 ( 4.4A)
G3P  A 301 (-3.9A)
 1.24A 5g08A-5ey5A:
0.5		 5g08A-5ey5A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 12 ASP B 326
ALA B 266
ALA B 265
GLY B 262
THR B 261
 None
 1.04A 5igjA-5ey5B:
undetectable		 5igjA-5ey5B:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 5ey5 LBCA-B
LBCATS-A
(synthetic
construct) 		4 / 6 SER A  55
GLY B 289
ASN A 104
ILE B 292
 None
 1.07A 5j4nA-5ey5A:
undetectable		 5j4nA-5ey5A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5ey5 LBCA-B
(synthetic
construct) 		4 / 7 HIS B 112
HIS B 277
ILE B 185
VAL B 189
 None
 1.22A 5kkzC-5ey5B:
undetectable
5kkzE-5ey5B:
undetectable		 5kkzC-5ey5B:
19.36
5kkzE-5ey5B:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5ey5 LBCA-B
(synthetic
construct) 		4 / 7 HIS B 277
ILE B 185
VAL B 189
HIS B 112
 None
 1.19A 5kkzK-5ey5B:
undetectable
5kkzQ-5ey5B:
undetectable		 5kkzK-5ey5B:
21.96
5kkzQ-5ey5B:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 12 GLY B 132
VAL B 143
TYR B 183
ALA B 170
VAL B 128
 None
 1.19A 5n0oA-5ey5B:
undetectable		 5n0oA-5ey5B:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 12 GLY B 132
VAL B 143
TYR B 183
ALA B 170
VAL B 128
 None
 1.22A 5n0wA-5ey5B:
undetectable		 5n0wA-5ey5B:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 12 GLY B 132
TYR B 183
ILE B 104
ALA B 170
VAL B 128
 None
 1.12A 5n0xA-5ey5B:
undetectable		 5n0xA-5ey5B:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 12 GLY B 132
VAL B 143
TYR B 183
ALA B 170
VAL B 128
 None
 1.23A 5n0xB-5ey5B:
undetectable		 5n0xB-5ey5B:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5ey5 LBCATS-A
(synthetic
construct) 		4 / 7 VAL A 210
ILE A 208
VAL A 226
ALA A 227
 None
 0.74A 5osrA-5ey5A:
undetectable		 5osrA-5ey5A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5ey5 LBCA-B
(synthetic
construct) 		5 / 12 LEU B  21
VAL B  13
PRO B 191
PHE B   5
GLY B 231
 None
None
None
None
PLP  B 501 (-3.3A)
 1.26A 5xiqD-5ey5B:
undetectable		 5xiqD-5ey5B:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 5ey5 LBCA-B
(synthetic
construct) 		4 / 5 HIS B 350
ALA B 265
SER B 296
GLY B 256
 None
 1.15A 5yodB-5ey5B:
undetectable		 5yodB-5ey5B:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ey5 LBCA-B
(synthetic
construct) 		3 / 3 LEU B 268
ASN B 233
LEU B 301
 None
PLP  B 501 (-3.8A)
PLP  B 501 ( 4.9A)
 0.63A 6exiD-5ey5B:
3.0		 6exiD-5ey5B:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 12 SER B 298
THR B 162
ALA B 265
GLY B 108
ALA B 299
 None
 1.22A 6hwdV-5ey5B:
undetectable
6hwdb-5ey5B:
undetectable		 6hwdV-5ey5B:
14.24
6hwdb-5ey5B:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 12 SER B 298
THR B 162
ALA B 265
GLY B 108
ALA B 299
 None
 1.23A 6hwdH-5ey5B:
undetectable
6hwdN-5ey5B:
undetectable		 6hwdH-5ey5B:
14.24
6hwdN-5ey5B:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 5ey5 LBCA-B
(synthetic
construct) 		5 / 9 ALA B 299
GLY B 300
LEU B 301
GLY B 376
ARG B 138
 None
PLP  B 501 (-4.2A)
PLP  B 501 ( 4.9A)
None
None
 1.28A 6nm4B-5ey5B:
undetectable		 6nm4B-5ey5B:
18.56