SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eyb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 5eyb DNA-BINDING PROTEIN
REB1
(Schizosaccharomy
ces
pombe) 		3 / 3 TRP A 395
ARG A 352
THR A 396
 None
 0.92A 1df7A-5eybA:
undetectable		 1df7A-5eybA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 5eyb DNA-BINDING PROTEIN
REB1
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A 232
THR A 246
VAL A 243
 None
 0.86A 1hxbA-5eybA:
undetectable		 1hxbA-5eybA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5eyb DNA-BINDING PROTEIN
REB1
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A 340
ILE A 271
TRP A 272
 None
 1.23A 1m8eB-5eybA:
undetectable		 1m8eB-5eybA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 5eyb DNA-BINDING PROTEIN
REB1
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 239
ARG A 294
ASP A 240
ALA A 158
GLN A 244
 None
 1.30A 1oltA-5eybA:
undetectable		 1oltA-5eybA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 5eyb DNA-BINDING PROTEIN
REB1
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A 340
ASP A 348
ASP A 355
 None
 0.88A 2ejtA-5eybA:
undetectable		 2ejtA-5eybA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 5eyb DNA-BINDING PROTEIN
REB1
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A 232
THR A 246
VAL A 243
 None
 0.73A 2q64A-5eybA:
undetectable		 2q64A-5eybA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5eyb DNA-BINDING PROTEIN
REB1
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A 232
THR A 246
VAL A 243
 None
 0.82A 2qakA-5eybA:
undetectable		 2qakA-5eybA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 5eyb DNA-BINDING PROTEIN
REB1
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE A 249
PHE A 283
ILE A 280
PHE A 267
 None
 1.17A 2qb4A-5eybA:
undetectable		 2qb4A-5eybA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 5eyb DNA-BINDING PROTEIN
REB1
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A 313
TYR A 307
ASN A 269
 None
 0.89A 4ffwB-5eybA:
undetectable		 4ffwB-5eybA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 5eyb DNA-BINDING PROTEIN
REB1
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A 358
ASP A 355
ARG A 407
 None
 0.62A 4wq4B-5eybA:
undetectable		 4wq4B-5eybA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5eyb DNA-BINDING PROTEIN
REB1
(Schizosaccharomy
ces
pombe) 		5 / 10 PHE A 283
ILE A 280
ILE A 271
VAL A 303
ALA A 296
 None
 1.19A 5nukA-5eybA:
undetectable		 5nukA-5eybA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5eyb DNA-BINDING PROTEIN
REB1
(Schizosaccharomy
ces
pombe) 		4 / 5 ARG A 462
LEU A 466
GLN A 464
PHE A 467
 None
 1.11A 6nmpP-5eybA:
undetectable
6nmpW-5eybA:
undetectable		 6nmpP-5eybA:
18.77
6nmpW-5eybA:
10.12