SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eyf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXF_A_MTXA1278_1 (PTERIDINE REDUCTASE 2)	5eyf	GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN (Enterococcus faecium)	5 / 10	ARG A 118 TYR A 226 ASP A 68 TYR A 128 THR A 198	GGL A 301 (-2.9A) GGL A 301 (-4.8A) None None None	1.28A	1mxfA-5eyfA: undetectable	1mxfA-5eyfA: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXF_B_MTXB2278_1 (PTERIDINE REDUCTASE 2)	5eyf	GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN (Enterococcus faecium)	5 / 11	ARG A 118 TYR A 226 ASP A 68 TYR A 128 THR A 198	GGL A 301 (-2.9A) GGL A 301 (-4.8A) None None None	1.32A	1mxfB-5eyfA: undetectable	1mxfB-5eyfA: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXF_C_MTXC3278_1 (PTERIDINE REDUCTASE 2)	5eyf	GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN (Enterococcus faecium)	5 / 11	ARG A 118 TYR A 226 ASP A 68 TYR A 128 THR A 198	GGL A 301 (-2.9A) GGL A 301 (-4.8A) None None None	1.32A	1mxfC-5eyfA: undetectable	1mxfC-5eyfA: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXF_D_MTXD4278_1 (PTERIDINE REDUCTASE 2)	5eyf	GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN (Enterococcus faecium)	5 / 11	ARG A 118 TYR A 226 ASP A 68 TYR A 128 THR A 198	GGL A 301 (-2.9A) GGL A 301 (-4.8A) None None None	1.32A	1mxfD-5eyfA: undetectable	1mxfD-5eyfA: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NB9_A_RBFA401_1 (HYPOTHETICAL PROTEIN FLJ11149)	5eyf	GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN (Enterococcus faecium)	5 / 9	ILE A 33 ARG A 36 LEU A 80 ILE A 43 ASP A 106	None	1.34A	1nb9A-5eyfA: undetectable	1nb9A-5eyfA: 18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DTJ_B_THRB402_0 (ASPARTOKINASE)	5eyf	GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN (Enterococcus faecium)	5 / 9	ILE A 109 ILE A 43 GLY A 46 ALA A 107 THR A 76	None	1.39A	2dtjA-5eyfA: undetectable 2dtjB-5eyfA: undetectable	2dtjA-5eyfA: 23.62 2dtjB-5eyfA: 23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_C_SAMC300_0 (PUTATIVE RRNA METHYLASE)	5eyf	GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN (Enterococcus faecium)	5 / 12	GLY A 206 GLY A 132 LEU A 53 THR A 111 THR A 113	None None None GGL A 301 (-3.9A) GGL A 301 (-4.0A)	1.03A	3eeyC-5eyfA: undetectable	3eeyC-5eyfA: 24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_E_SAME300_0 (PUTATIVE RRNA METHYLASE)	5eyf	GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN (Enterococcus faecium)	5 / 12	GLY A 206 GLY A 132 LEU A 53 THR A 111 THR A 113	None None None GGL A 301 (-3.9A) GGL A 301 (-4.0A)	1.07A	3eeyE-5eyfA: undetectable	3eeyE-5eyfA: 24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_F_SAMF300_0 (PUTATIVE RRNA METHYLASE)	5eyf	GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN (Enterococcus faecium)	5 / 12	GLY A 206 GLY A 132 LEU A 53 THR A 111 THR A 113	None None None GGL A 301 (-3.9A) GGL A 301 (-4.0A)	1.15A	3eeyF-5eyfA: undetectable	3eeyF-5eyfA: 24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3S_E_9PLE1_1 (CYTOCHROME P450 2A13)	5eyf	GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN (Enterococcus faecium)	4 / 8	PHE A 262 ALA A 131 ASN A 201 THR A 51	None	0.92A	3t3sE-5eyfA: undetectable	3t3sE-5eyfA: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TF1_A_ACTA191_0 (METHYL-ACCEPTING CHEMOTAXIS PROTEIN)	5eyf	GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN (Enterococcus faecium)	4 / 5	THR A 198 ILE A 167 PHE A 221 LEU A 149	None	1.46A	3tf1A-5eyfA: undetectable	3tf1A-5eyfA: 21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y1D_D_DVAD5_0 (CYCLIC HEXAPEPTIDE CYC[NDPOPPKID] INTEGRASE)	5eyf	GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN (Enterococcus faecium)	3 / 3	GLU A 180 LYS A 159 ASN A 181	None	1.00A	4y1dA-5eyfA: undetectable 4y1dD-5eyfA: undetectable	4y1dA-5eyfA: 21.83 4y1dD-5eyfA: 2.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IWU_A_ERYA404_1 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	5eyf	GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN (Enterococcus faecium)	4 / 6	GLY A 55 ILE A 97 ARG A 96 TYR A 128	None None GGL A 301 (-3.1A) None	1.07A	5iwuA-5eyfA: undetectable	5iwuA-5eyfA: 20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L4E_D_EDPD402_1 (PROTON-GATED ION CHANNEL)	5eyf	GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN (Enterococcus faecium)	4 / 8	THR A 111 SER A 93 THR A 199 SER A 163	GGL A 301 (-3.9A) GGL A 301 (-2.6A) None GGL A 301 ( 4.1A)	0.76A	5l4eA-5eyfA: undetectable 5l4eB-5eyfA: undetectable 5l4eC-5eyfA: undetectable 5l4eD-5eyfA: undetectable 5l4eE-5eyfA: undetectable	5l4eA-5eyfA: 24.59 5l4eB-5eyfA: 24.59 5l4eC-5eyfA: 24.59 5l4eD-5eyfA: 24.59 5l4eE-5eyfA: 24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L4E_D_EDPD402_1 (PROTON-GATED ION CHANNEL)	5eyf	GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN (Enterococcus faecium)	4 / 8	THR A 199 SER A 163 THR A 111 SER A 93	None GGL A 301 ( 4.1A) GGL A 301 (-3.9A) GGL A 301 (-2.6A)	0.75A	5l4eA-5eyfA: undetectable 5l4eB-5eyfA: undetectable 5l4eC-5eyfA: undetectable 5l4eD-5eyfA: undetectable 5l4eE-5eyfA: undetectable	5l4eA-5eyfA: 24.59 5l4eB-5eyfA: 24.59 5l4eC-5eyfA: 24.59 5l4eD-5eyfA: 24.59 5l4eE-5eyfA: 24.59

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MXF_A_MTXA1278_1","PTERIDINE REDUCTASE 2","5eyf","GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN","Enterococcus faecium",5,"ARG A 118;TYR A 226;ASP A  68;TYR A 128;THR A 198","GGL A 301 (-2.9A);GGL A 301 (-4.8A);None;None;None","1.28A","1mxfA-5eyfA:undetectable","1mxfA-5eyfA:21.58"],["1MXF_B_MTXB2278_1","PTERIDINE REDUCTASE 2","5eyf","GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN","Enterococcus faecium",5,"ARG A 118;TYR A 226;ASP A  68;TYR A 128;THR A 198","GGL A 301 (-2.9A);GGL A 301 (-4.8A);None;None;None","1.32A","1mxfB-5eyfA:undetectable","1mxfB-5eyfA:21.58"],["1MXF_C_MTXC3278_1","PTERIDINE REDUCTASE 2","5eyf","GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN","Enterococcus faecium",5,"ARG A 118;TYR A 226;ASP A  68;TYR A 128;THR A 198","GGL A 301 (-2.9A);GGL A 301 (-4.8A);None;None;None","1.32A","1mxfC-5eyfA:undetectable","1mxfC-5eyfA:21.58"],["1MXF_D_MTXD4278_1","PTERIDINE REDUCTASE 2","5eyf","GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN","Enterococcus faecium",5,"ARG A 118;TYR A 226;ASP A  68;TYR A 128;THR A 198","GGL A 301 (-2.9A);GGL A 301 (-4.8A);None;None;None","1.32A","1mxfD-5eyfA:undetectable","1mxfD-5eyfA:21.58"],["1NB9_A_RBFA401_1","HYPOTHETICAL PROTEIN FLJ11149","5eyf","GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN","Enterococcus faecium",5,"ILE A  33;ARG A  36;LEU A  80;ILE A  43;ASP A 106","None","1.34A","1nb9A-5eyfA:undetectable","1nb9A-5eyfA:18.93"],["2DTJ_B_THRB402_0","ASPARTOKINASE","5eyf","GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN","Enterococcus faecium",5,"ILE A 109;ILE A  43;GLY A  46;ALA A 107;THR A  76","None","1.39A","2dtjA-5eyfA:undetectable;2dtjB-5eyfA:undetectable","2dtjA-5eyfA:23.62;2dtjB-5eyfA:23.62"],["3EEY_C_SAMC300_0","PUTATIVE RRNA METHYLASE","5eyf","GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN","Enterococcus faecium",5,"GLY A 206;GLY A 132;LEU A  53;THR A 111;THR A 113","None;None;None;GGL A 301 (-3.9A);GGL A 301 (-4.0A)","1.03A","3eeyC-5eyfA:undetectable","3eeyC-5eyfA:24.25"],["3EEY_E_SAME300_0","PUTATIVE RRNA METHYLASE","5eyf","GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN","Enterococcus faecium",5,"GLY A 206;GLY A 132;LEU A  53;THR A 111;THR A 113","None;None;None;GGL A 301 (-3.9A);GGL A 301 (-4.0A)","1.07A","3eeyE-5eyfA:undetectable","3eeyE-5eyfA:24.25"],["3EEY_F_SAMF300_0","PUTATIVE RRNA METHYLASE","5eyf","GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN","Enterococcus faecium",5,"GLY A 206;GLY A 132;LEU A  53;THR A 111;THR A 113","None;None;None;GGL A 301 (-3.9A);GGL A 301 (-4.0A)","1.15A","3eeyF-5eyfA:undetectable","3eeyF-5eyfA:24.25"],["3T3S_E_9PLE1_1","CYTOCHROME P450 2A13","5eyf","GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN","Enterococcus faecium",4,"PHE A 262;ALA A 131;ASN A 201;THR A  51","None","0.92A","3t3sE-5eyfA:undetectable","3t3sE-5eyfA:16.67"],["3TF1_A_ACTA191_0","METHYL-ACCEPTING CHEMOTAXIS PROTEIN","5eyf","GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN","Enterococcus faecium",4,"THR A 198;ILE A 167;PHE A 221;LEU A 149","None","1.46A","3tf1A-5eyfA:undetectable","3tf1A-5eyfA:21.57"],["4Y1D_D_DVAD5_0","CYCLIC HEXAPEPTIDE CYC[NDPOPPKID];INTEGRASE","5eyf","GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN","Enterococcus faecium",3,"GLU A 180;LYS A 159;ASN A 181","None","1.00A","4y1dA-5eyfA:undetectable;4y1dD-5eyfA:undetectable","4y1dA-5eyfA:21.83;4y1dD-5eyfA:2.14"],["5IWU_A_ERYA404_1","MACROLIDE 2'-PHOSPHOTRANSFERASE II","5eyf","GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN","Enterococcus faecium",4,"GLY A  55;ILE A  97;ARG A  96;TYR A 128","None;None;GGL A 301 (-3.1A);None","1.07A","5iwuA-5eyfA:undetectable","5iwuA-5eyfA:20.52"],["5L4E_D_EDPD402_1","PROTON-GATED ION CHANNEL;PROTON-GATED ION CHANNEL;PROTON-GATED ION CHANNEL;PROTON-GATED ION CHANNEL;PROTON-GATED ION CHANNEL","5eyf","GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN","Enterococcus faecium",4,"THR A 111;SER A  93;THR A 199;SER A 163","GGL A 301 (-3.9A);GGL A 301 (-2.6A);None;GGL A 301 ( 4.1A)","0.76A","5l4eA-5eyfA:undetectable;5l4eB-5eyfA:undetectable;5l4eC-5eyfA:undetectable;5l4eD-5eyfA:undetectable;5l4eE-5eyfA:undetectable","5l4eA-5eyfA:24.59;5l4eB-5eyfA:24.59;5l4eC-5eyfA:24.59;5l4eD-5eyfA:24.59;5l4eE-5eyfA:24.59"],["5L4E_D_EDPD402_1","PROTON-GATED ION CHANNEL;PROTON-GATED ION CHANNEL;PROTON-GATED ION CHANNEL;PROTON-GATED ION CHANNEL;PROTON-GATED ION CHANNEL","5eyf","GLUTAMATE ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN","Enterococcus faecium",4,"THR A 199;SER A 163;THR A 111;SER A  93","None;GGL A 301 ( 4.1A);GGL A 301 (-3.9A);GGL A 301 (-2.6A)","0.75A","5l4eA-5eyfA:undetectable;5l4eB-5eyfA:undetectable;5l4eC-5eyfA:undetectable;5l4eD-5eyfA:undetectable;5l4eE-5eyfA:undetectable","5l4eA-5eyfA:24.59;5l4eB-5eyfA:24.59;5l4eC-5eyfA:24.59;5l4eD-5eyfA:24.59;5l4eE-5eyfA:24.59"]]