SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eyi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5eyi NON-STRUCTURAL
PROTEIN 11
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 5 PHE A 205
LEU A  50
PHE A 103
SER A   3
 None
None
None
PG0  A 303 (-3.6A)
 1.18A 1wrlC-5eyiA:
undetectable		 1wrlC-5eyiA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5eyi NON-STRUCTURAL
PROTEIN 11
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 7 LEU A  98
PHE A 205
LEU A  50
PHE A 103
 None
 0.86A 1wrlE-5eyiA:
undetectable
1wrlF-5eyiA:
undetectable		 1wrlE-5eyiA:
14.22
1wrlF-5eyiA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 5eyi NON-STRUCTURAL
PROTEIN 11
(Porcine
reproductive
and
respiratory
syndrome
virus) 		3 / 3 TYR A  69
GLY A 106
PHE A  76
 PG0  A 303 (-4.2A)
None
None
 0.59A 2m2pB-5eyiA:
undetectable		 2m2pB-5eyiA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 5eyi NON-STRUCTURAL
PROTEIN 11
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 7 ASP A 134
VAL A 140
ALA A 173
THR A 217
 None
None
None
CL  A 302 (-3.5A)
 1.00A 2q6oA-5eyiA:
undetectable		 2q6oA-5eyiA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 5eyi NON-STRUCTURAL
PROTEIN 11
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 5 ALA A 173
GLY A 133
CYH A 143
HIS A 144
 None
None
None
CL  A 302 (-4.8A)
 1.02A 2yldA-5eyiA:
undetectable		 2yldA-5eyiA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 5eyi NON-STRUCTURAL
PROTEIN 11
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 5 ALA A 173
GLY A 133
CYH A 143
HIS A 144
 None
None
None
CL  A 302 (-4.8A)
 1.09A 2ylgA-5eyiA:
undetectable		 2ylgA-5eyiA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5eyi NON-STRUCTURAL
PROTEIN 11
(Porcine
reproductive
and
respiratory
syndrome
virus) 		5 / 12 GLY A 106
ALA A  67
PHE A 103
THR A 105
LEU A 116
 None
 1.34A 3dh0A-5eyiA:
undetectable		 3dh0A-5eyiA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 5eyi NON-STRUCTURAL
PROTEIN 11
(Porcine
reproductive
and
respiratory
syndrome
virus) 		5 / 11 LEU A 186
LEU A 183
GLU A 120
ARG A 107
MET A 201
 None
 1.15A 3hm1B-5eyiA:
undetectable		 3hm1B-5eyiA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5eyi NON-STRUCTURAL
PROTEIN 11
(Porcine
reproductive
and
respiratory
syndrome
virus) 		5 / 9 TYR A 219
THR A 177
GLY A 164
ALA A 173
THR A 139
 None
 1.48A 3jusB-5eyiA:
undetectable		 3jusB-5eyiA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 5eyi NON-STRUCTURAL
PROTEIN 11
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 5 ALA A 173
GLY A 133
CYH A 143
HIS A 144
 None
None
None
CL  A 302 (-4.8A)
 1.02A 3zwiA-5eyiA:
undetectable		 3zwiA-5eyiA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CIP_A_ASCA130_0
(CYTOCHROME C')		 5eyi NON-STRUCTURAL
PROTEIN 11
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 4 ALA A 173
GLY A 133
CYH A 143
HIS A 144
 None
None
None
CL  A 302 (-4.8A)
 1.02A 4cipA-5eyiA:
undetectable		 4cipA-5eyiA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 5eyi NON-STRUCTURAL
PROTEIN 11
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 5 THR A 105
GLY A  66
VAL A  82
PRO A  80
 None
 1.06A 4grkA-5eyiA:
undetectable		 4grkA-5eyiA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 5eyi NON-STRUCTURAL
PROTEIN 11
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 4 ILE A 108
VAL A 181
VAL A 146
ARG A 113
 None
 1.33A 4m6tA-5eyiA:
undetectable		 4m6tA-5eyiA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 5eyi NON-STRUCTURAL
PROTEIN 11
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 5 ALA A 173
GLY A 133
CYH A 143
HIS A 144
 None
None
None
CL  A 302 (-4.8A)
 1.08A 5jliA-5eyiA:
undetectable		 5jliA-5eyiA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSL_A_ASCA202_0
(CYTOCHROME C')		 5eyi NON-STRUCTURAL
PROTEIN 11
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 4 ALA A 173
GLY A 133
CYH A 143
HIS A 144
 None
None
None
CL  A 302 (-4.8A)
 1.04A 5jslA-5eyiA:
undetectable		 5jslA-5eyiA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 5eyi NON-STRUCTURAL
PROTEIN 11
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 5 ALA A 173
GLY A 133
CYH A 143
HIS A 144
 None
None
None
CL  A 302 (-4.8A)
 1.07A 5jt4A-5eyiA:
undetectable		 5jt4A-5eyiA:
22.47