SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eyt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		4 / 7 LEU A 306
PHE A  24
MET A  20
SER A  17
 None
 0.78A 1wrlA-5eytA:
undetectable
1wrlB-5eytA:
undetectable		 1wrlA-5eytA:
11.48
1wrlB-5eytA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		4 / 6 LEU A 306
PHE A  24
MET A  20
SER A  17
 None
 0.71A 1wrlB-5eytA:
undetectable		 1wrlB-5eytA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		4 / 5 LEU A 306
PHE A  24
MET A  20
SER A  17
 None
 0.82A 1wrlC-5eytA:
undetectable		 1wrlC-5eytA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		4 / 7 LEU A 306
PHE A  24
MET A  20
SER A  17
 None
 0.69A 1wrlE-5eytA:
undetectable		 1wrlE-5eytA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		5 / 11 LEU A 336
ILE A 246
PHE A  24
ALA A 343
LEU A 122
 None
 1.07A 2q72A-5eytA:
undetectable		 2q72A-5eytA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		5 / 12 LEU A 336
ILE A 246
PHE A  24
ALA A 343
LEU A 122
 None
 1.08A 2qb4A-5eytA:
1.2		 2qb4A-5eytA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		5 / 11 LEU A 336
ILE A 246
PHE A  24
ALA A 343
LEU A 122
 None
 1.09A 2qjuA-5eytA:
undetectable		 2qjuA-5eytA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		4 / 6 LEU A  47
PHE A  49
PHE A 207
LEU A 217
 None
 1.02A 3abkP-5eytA:
4.6
3abkW-5eytA:
undetectable		 3abkP-5eytA:
18.88
3abkW-5eytA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		4 / 7 LEU A  47
PHE A  49
PHE A 207
LEU A 217
 None
 0.95A 3ag2P-5eytA:
3.8
3ag2W-5eytA:
undetectable		 3ag2P-5eytA:
18.88
3ag2W-5eytA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		4 / 7 LEU A  47
PHE A  49
PHE A 207
LEU A 217
 None
 0.99A 3asnP-5eytA:
4.6
3asnW-5eytA:
undetectable		 3asnP-5eytA:
18.88
3asnW-5eytA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		4 / 7 LEU A  47
PHE A  49
PHE A 207
LEU A 217
 None
 0.95A 3asoP-5eytA:
4.6
3asoW-5eytA:
undetectable		 3asoP-5eytA:
18.88
3asoW-5eytA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		5 / 11 GLN A 320
VAL A 317
TYR A 305
ILE A 309
ILE A 246
 None
 1.29A 3ganA-5eytA:
undetectable		 3ganA-5eytA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		4 / 4 LEU A 372
PRO A 373
LEU A 375
ARG A 151
 None
 1.23A 3hcoA-5eytA:
undetectable		 3hcoA-5eytA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		3 / 3 LYS A  13
ARG A  18
LYS A  29
 None
 1.40A 3okxA-5eytA:
undetectable		 3okxA-5eytA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		5 / 12 LEU A 206
ALA A 193
GLY A 195
GLY A 103
LEU A  40
 None
 1.05A 3ou6A-5eytA:
undetectable		 3ou6A-5eytA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		5 / 12 LEU A 206
ALA A 193
GLY A 195
GLY A 103
LEU A  40
 None
 1.08A 3ou6B-5eytA:
undetectable		 3ou6B-5eytA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		5 / 12 LEU A 206
ALA A 193
GLY A 195
GLY A 103
LEU A  40
 None
 1.06A 3ou7B-5eytA:
undetectable		 3ou7B-5eytA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		5 / 12 LEU A 206
ALA A 193
GLY A 195
GLY A 103
LEU A  40
 None
 1.06A 3ou7D-5eytA:
undetectable		 3ou7D-5eytA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		4 / 6 LEU A  47
PHE A  49
PHE A 207
LEU A 217
 None
 0.98A 3wg7C-5eytA:
4.6
3wg7J-5eytA:
undetectable		 3wg7C-5eytA:
18.88
3wg7J-5eytA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		4 / 6 LEU A  47
PHE A  49
PHE A 207
LEU A 217
 None
 0.95A 3wg7P-5eytA:
4.6
3wg7W-5eytA:
undetectable		 3wg7P-5eytA:
18.88
3wg7W-5eytA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		5 / 12 THR A 105
ALA A 104
LEU A 102
LEU A  40
LEU A  36
 None
 1.30A 4xi3D-5eytA:
undetectable		 4xi3D-5eytA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		5 / 11 LEU A  36
PHE A 203
LEU A 217
GLY A 195
SER A 225
 None
 1.36A 4zbqA-5eytA:
undetectable		 4zbqA-5eytA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		5 / 12 ALA A 193
GLY A 192
LEU A  40
PHE A 203
LEU A 206
 None
 1.13A 5w7pA-5eytA:
undetectable		 5w7pA-5eytA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		4 / 6 LEU A  47
PHE A  49
PHE A 207
LEU A 217
 None
 0.98A 5x19P-5eytA:
3.9		 5x19P-5eytA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		4 / 5 LEU A  47
PHE A  49
PHE A 207
LEU A 217
 None
 1.00A 5x1bP-5eytA:
4.0		 5x1bP-5eytA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		4 / 7 LEU A  47
PHE A  49
PHE A 207
LEU A 217
 None
 1.00A 5x1fP-5eytA:
3.9
5x1fW-5eytA:
undetectable		 5x1fP-5eytA:
18.88
5x1fW-5eytA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 5eyt ADENYLOSUCCINATE
LYASE
(Schistosoma
mansoni) 		3 / 3 LEU A 183
VAL A 242
ASP A 243
 None
 0.52A 5x23A-5eytA:
undetectable		 5x23A-5eytA:
25.00