SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eyw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 5eyw TRIOSEPHOSPHATE
ISOMERASE
(Litopenaeus
vannamei) 		4 / 8 VAL A  42
ALA A 236
TRP A  13
PHE A  28
 None
 1.10A 1dmiA-5eywA:
undetectable
1dmiB-5eywA:
undetectable		 1dmiA-5eywA:
18.79
1dmiB-5eywA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 5eyw TRIOSEPHOSPHATE
ISOMERASE
(Litopenaeus
vannamei) 		3 / 3 ALA A 199
VAL A 197
TRP A 158
 None
 1.00A 1gmkC-5eywA:
undetectable
1gmkD-5eywA:
undetectable		 1gmkC-5eywA:
6.42
1gmkD-5eywA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 5eyw TRIOSEPHOSPHATE
ISOMERASE
(Litopenaeus
vannamei) 		5 / 9 LEU A 151
LEU A 193
ILE A 207
VAL A 144
PHE A 145
 None
 1.36A 1gx8A-5eywA:
undetectable		 1gx8A-5eywA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 5eyw TRIOSEPHOSPHATE
ISOMERASE
(Litopenaeus
vannamei) 		5 / 11 ALA A 164
GLY A 233
GLU A 166
ILE A 125
HIS A  96
 None
PGA  A 301 (-3.3A)
PGA  A 301 (-2.6A)
None
PGA  A 301 (-4.2A)
 1.12A 1pg2A-5eywA:
undetectable		 1pg2A-5eywA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 5eyw TRIOSEPHOSPHATE
ISOMERASE
(Litopenaeus
vannamei) 		4 / 8 LYS A  14
THR A 176
SER A  97
GLU A 133
 PGA  A 301 (-2.7A)
None
None
None
 1.30A 1xr2B-5eywA:
3.6		 1xr2B-5eywA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 5eyw TRIOSEPHOSPHATE
ISOMERASE
(Litopenaeus
vannamei) 		5 / 10 ILE A  62
ILE A  60
ASN A  12
VAL A   9
ILE A  93
 None
None
PGA  A 301 (-4.1A)
None
None
 1.18A 2nnhB-5eywA:
undetectable		 2nnhB-5eywA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 5eyw TRIOSEPHOSPHATE
ISOMERASE
(Litopenaeus
vannamei) 		5 / 12 ILE A 244
PHE A 230
ALA A 222
ASN A 246
THR A  38
 None
 0.85A 2rlcA-5eywA:
undetectable		 2rlcA-5eywA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 5eyw TRIOSEPHOSPHATE
ISOMERASE
(Litopenaeus
vannamei) 		4 / 8 GLY A 115
HIS A 116
ILE A 110
GLU A 112
 None
 0.89A 2x0pA-5eywA:
undetectable		 2x0pA-5eywA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 5eyw TRIOSEPHOSPHATE
ISOMERASE
(Litopenaeus
vannamei) 		5 / 11 ALA A 164
GLY A 233
GLU A 166
ILE A 125
HIS A  96
 None
PGA  A 301 (-3.3A)
PGA  A 301 (-2.6A)
None
PGA  A 301 (-4.2A)
 1.04A 2x1lA-5eywA:
2.5		 2x1lA-5eywA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 5eyw TRIOSEPHOSPHATE
ISOMERASE
(Litopenaeus
vannamei) 		5 / 12 ALA A 164
GLY A 233
GLU A 166
ILE A 125
HIS A  96
 None
PGA  A 301 (-3.3A)
PGA  A 301 (-2.6A)
None
PGA  A 301 (-4.2A)
 1.03A 2x1lB-5eywA:
undetectable		 2x1lB-5eywA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 5eyw TRIOSEPHOSPHATE
ISOMERASE
(Litopenaeus
vannamei) 		5 / 11 ALA A 164
GLY A 233
GLU A 166
ILE A 125
HIS A  96
 None
PGA  A 301 (-3.3A)
PGA  A 301 (-2.6A)
None
PGA  A 301 (-4.2A)
 1.07A 2x1lC-5eywA:
undetectable		 2x1lC-5eywA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 5eyw TRIOSEPHOSPHATE
ISOMERASE
(Litopenaeus
vannamei) 		4 / 8 PHE A 230
ASN A 217
TYR A 209
LEU A 221
 None
 1.13A 3rqwC-5eywA:
undetectable
3rqwD-5eywA:
undetectable		 3rqwC-5eywA:
19.53
3rqwD-5eywA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5eyw TRIOSEPHOSPHATE
ISOMERASE
(Litopenaeus
vannamei) 		4 / 4 PRO A 126
LEU A 163
ILE A 207
ARG A 190
 None
 1.50A 4f4dA-5eywA:
undetectable		 4f4dA-5eywA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5eyw TRIOSEPHOSPHATE
ISOMERASE
(Litopenaeus
vannamei) 		4 / 5 GLY A 229
ASP A 228
GLU A 166
VAL A 144
 None
None
PGA  A 301 (-2.6A)
None
 1.16A 4nkvD-5eywA:
undetectable		 4nkvD-5eywA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5eyw TRIOSEPHOSPHATE
ISOMERASE
(Litopenaeus
vannamei) 		5 / 12 ALA A  64
ILE A  93
ASN A  12
GLY A  43
ASN A  66
 None
None
PGA  A 301 (-4.1A)
None
None
 1.24A 4obwD-5eywA:
undetectable		 4obwD-5eywA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5eyw TRIOSEPHOSPHATE
ISOMERASE
(Litopenaeus
vannamei) 		5 / 12 GLY A 210
GLY A 211
THR A 176
PHE A 241
ILE A 244
 None
PGA  A 301 ( 3.8A)
None
None
None
 1.16A 4zvmA-5eywA:
undetectable
4zvmB-5eywA:
undetectable		 4zvmA-5eywA:
22.14
4zvmB-5eywA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5eyw TRIOSEPHOSPHATE
ISOMERASE
(Litopenaeus
vannamei) 		4 / 6 ILE A 155
ALA A 117
VAL A 124
HIS A 116
 None
 0.90A 5eclD-5eywA:
undetectable		 5eclD-5eywA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 5eyw TRIOSEPHOSPHATE
ISOMERASE
(Litopenaeus
vannamei) 		5 / 11 VAL A 213
SER A 212
THR A 173
TYR A 209
LEU A 221
 None
PGA  A 301 (-3.6A)
None
None
None
 1.39A 5jh7B-5eywA:
undetectable		 5jh7B-5eywA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 5eyw TRIOSEPHOSPHATE
ISOMERASE
(Litopenaeus
vannamei) 		5 / 11 VAL A 213
SER A 212
THR A 173
TYR A 209
LEU A 221
 None
PGA  A 301 (-3.6A)
None
None
None
 1.37A 5jh7D-5eywA:
undetectable		 5jh7D-5eywA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 5eyw TRIOSEPHOSPHATE
ISOMERASE
(Litopenaeus
vannamei) 		5 / 12 ASN A  59
VAL A  40
ILE A 245
GLY A  32
ILE A  60
 None
 1.00A 5kqyA-5eywA:
undetectable		 5kqyA-5eywA:
18.07