SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ez3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
3 / 3 ALA A 149
VAL A 303
TRP A 433
None
None
MRD  A 601 ( 3.2A)
0.91A 1grmA-5ez3A:
undetectable
1grmA-5ez3A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
3 / 3 ALA A 149
VAL A 303
TRP A 433
None
None
MRD  A 601 ( 3.2A)
0.91A 1grmB-5ez3A:
undetectable
1grmB-5ez3A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 11 VAL A 356
TYR A 549
GLY A 533
LEU A 535
VAL A 326
None
1.35A 1i9jH-5ez3A:
undetectable
1i9jL-5ez3A:
undetectable
1i9jH-5ez3A:
17.38
1i9jL-5ez3A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 11 ALA A 323
TYR A 549
LEU A 401
ALA A 398
ALA A 427
None
0.99A 1jinA-5ez3A:
1.1
1jinA-5ez3A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
3 / 3 THR A 145
PRO A 143
THR A 147
MRD  A 601 (-3.7A)
None
None
0.64A 209dC-5ez3A:
undetectable
209dC-5ez3A:
2.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
4 / 6 LEU A 448
LEU A 494
PRO A 388
VAL A 389
None
1.13A 2dqyC-5ez3A:
undetectable
2dqyC-5ez3A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 12 ARG A 508
GLY A 358
ALA A 357
ILE A 544
ILE A 515
None
0.91A 2hs1A-5ez3A:
undetectable
2hs1A-5ez3A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 12 SER A 244
LEU A 188
GLY A 286
PHE A 246
VAL A 160
None
1.08A 2kceB-5ez3A:
undetectable
2kceB-5ez3A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 12 VAL A 186
ALA A 232
LEU A 234
LEU A 154
SER A 165
None
1.15A 2oipC-5ez3A:
undetectable
2oipC-5ez3A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_B_CSCB1384_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 12 THR A 235
LEU A 234
TYR A  91
PHE A 281
VAL A 279
None
1.35A 2vaxB-5ez3A:
undetectable
2vaxB-5ez3A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_D_CSCD1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 12 THR A 235
LEU A 234
TYR A  91
PHE A 281
VAL A 279
None
1.30A 2vaxD-5ez3A:
undetectable
2vaxD-5ez3A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_H_CSCH1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 12 THR A 235
LEU A 234
TYR A  91
PHE A 281
VAL A 279
None
1.34A 2vaxH-5ez3A:
undetectable
2vaxH-5ez3A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_I_CSCI1384_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 12 THR A 235
LEU A 234
TYR A  91
PHE A 281
VAL A 279
None
1.35A 2vaxI-5ez3A:
undetectable
2vaxI-5ez3A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 12 ALA A  39
ALA A 373
ALA A 383
THR A 387
LEU A 308
None
MPD  A 602 ( 4.7A)
MPD  A 602 ( 3.9A)
None
None
1.28A 2x2nB-5ez3A:
undetectable
2x2nB-5ez3A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 12 ILE A 544
ILE A 545
ALA A 350
LEU A 349
ALA A 315
None
0.96A 2yvlA-5ez3A:
undetectable
2yvlA-5ez3A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 12 ILE A 544
ILE A 545
ALA A 350
LEU A 349
ALA A 315
None
0.96A 2yvlB-5ez3A:
undetectable
2yvlB-5ez3A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 12 ILE A 544
ILE A 545
ALA A 350
LEU A 349
ALA A 315
None
0.97A 2yvlC-5ez3A:
undetectable
2yvlC-5ez3A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 12 VAL A 186
ALA A 232
LEU A 234
LEU A 154
SER A 165
None
1.11A 3hj3C-5ez3A:
undetectable
3hj3C-5ez3A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 12 VAL A 186
ALA A 232
LEU A 234
LEU A 154
SER A 165
None
1.12A 3hj3D-5ez3A:
undetectable
3hj3D-5ez3A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 9 ALA A 480
LEU A 498
ILE A 462
LEU A 466
ILE A 474
None
1.23A 3jw3B-5ez3A:
undetectable
3jw3B-5ez3A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
4 / 6 LEU A 107
ALA A  53
LEU A 132
THR A 133
None
1.12A 3rozA-5ez3A:
undetectable
3rozA-5ez3A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
3 / 3 TYR A 532
PHE A 500
ARG A 529
None
1.02A 4g19D-5ez3A:
undetectable
4g19D-5ez3A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 11 ALA A 373
ALA A 369
ALA A 383
THR A 387
LEU A 305
MPD  A 602 ( 4.7A)
None
MPD  A 602 ( 3.9A)
None
MPD  A 602 ( 4.9A)
1.15A 4j6cA-5ez3A:
0.7
4j6cA-5ez3A:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 10 ALA A 373
ALA A 369
ALA A 383
THR A 387
LEU A 305
MPD  A 602 ( 4.7A)
None
MPD  A 602 ( 3.9A)
None
MPD  A 602 ( 4.9A)
1.14A 4j6cB-5ez3A:
undetectable
4j6cB-5ez3A:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 12 ALA A 373
ALA A 369
ALA A 383
THR A 387
LEU A 305
MPD  A 602 ( 4.7A)
None
MPD  A 602 ( 3.9A)
None
MPD  A 602 ( 4.9A)
1.12A 4j6dA-5ez3A:
undetectable
4j6dA-5ez3A:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 12 ALA A 373
ALA A 369
ALA A 383
THR A 387
LEU A 305
MPD  A 602 ( 4.7A)
None
MPD  A 602 ( 3.9A)
None
MPD  A 602 ( 4.9A)
1.13A 4j6dB-5ez3A:
undetectable
4j6dB-5ez3A:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 11 ALA A 373
ALA A 369
ALA A 383
THR A 387
LEU A 305
MPD  A 602 ( 4.7A)
None
MPD  A 602 ( 3.9A)
None
MPD  A 602 ( 4.9A)
1.14A 4jbtB-5ez3A:
undetectable
4jbtB-5ez3A:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 11 GLY A 321
ARG A 319
GLY A 316
ILE A 462
LEU A 477
None
1.12A 4kt0A-5ez3A:
undetectable
4kt0J-5ez3A:
undetectable
4kt0A-5ez3A:
22.36
4kt0J-5ez3A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 12 VAL A 186
ALA A 232
LEU A 234
LEU A 154
SER A 165
None
1.16A 4q0dA-5ez3A:
undetectable
4q0dA-5ez3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 12 VAL A 186
ALA A 232
LEU A 234
LEU A 154
SER A 165
None
1.16A 4q0dB-5ez3A:
undetectable
4q0dB-5ez3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 12 VAL A 186
ALA A 232
LEU A 234
LEU A 154
SER A 165
None
1.16A 4q0dE-5ez3A:
undetectable
4q0dE-5ez3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 12 THR A 360
ALA A 361
GLU A 506
LEU A 510
ARG A 368
None
1.27A 4xi3D-5ez3A:
undetectable
4xi3D-5ez3A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
4 / 8 ALA A 503
PHE A 519
GLY A 358
ALA A 359
None
0.70A 4zjzA-5ez3A:
undetectable
4zjzA-5ez3A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
4 / 8 VAL A 390
LEU A 507
GLY A 358
ALA A 359
None
0.82A 5f1aA-5ez3A:
0.1
5f1aA-5ez3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
4 / 7 VAL A 390
LEU A 507
GLY A 358
ALA A 359
None
0.86A 5f1aB-5ez3A:
undetectable
5f1aB-5ez3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
4 / 7 LEU A 344
THR A 531
THR A 530
MET A 345
None
1.10A 5jq7B-5ez3A:
undetectable
5jq7B-5ez3A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 12 ALA A 152
LEU A 151
ALA A 149
THR A 145
THR A 304
None
None
None
MRD  A 601 (-3.7A)
MPD  A 602 ( 4.6A)
1.16A 5k9dA-5ez3A:
undetectable
5k9dA-5ez3A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 12 MET A 318
ALA A 357
LEU A 401
ILE A 397
PHE A 500
None
1.37A 5vlmB-5ez3A:
undetectable
5vlmB-5ez3A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 12 GLU A  49
LEU A 308
ALA A 128
GLY A 106
LEU A 107
None
0.95A 6b0cD-5ez3A:
undetectable
6b0cD-5ez3A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 11 THR A 387
ARG A 126
ALA A 149
THR A 145
ALA A 134
None
None
None
MRD  A 601 (-3.7A)
None
1.41A 6efnA-5ez3A:
undetectable
6efnA-5ez3A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis)
5 / 10 LEU A 498
VAL A 389
VAL A 458
ALA A 505
LEU A 362
None
1.22A 6h1lA-5ez3A:
undetectable
6h1lA-5ez3A:
20.68