SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ez7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5ez7 FLAVOENZYME PA4991
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 241
LEU A 270
ALA A 289
ALA A 291
LEU A 298
 None
None
None
None
HG  A 402 ( 4.6A)
 1.39A 1kt5A-5ez7A:
undetectable		 1kt5A-5ez7A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 5ez7 FLAVOENZYME PA4991
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 171
PRO A 379
PRO A 380
GLY A  42
LEU A  34
 None
None
None
FAD  A 401 ( 4.6A)
None
 0.76A 2uvnA-5ez7A:
undetectable		 2uvnA-5ez7A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 5ez7 FLAVOENZYME PA4991
(Pseudomonas
aeruginosa) 		5 / 11 ILE A  16
LEU A 346
ILE A  52
VAL A  93
LEU A  90
 FAD  A 401 (-4.8A)
FAD  A 401 (-4.3A)
None
None
None
 1.08A 3a51A-5ez7A:
undetectable		 3a51A-5ez7A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 5ez7 FLAVOENZYME PA4991
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  16
LEU A 346
ILE A  52
VAL A  93
LEU A  90
 FAD  A 401 (-4.8A)
FAD  A 401 (-4.3A)
None
None
None
 1.07A 3a51D-5ez7A:
undetectable		 3a51D-5ez7A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 5ez7 FLAVOENZYME PA4991
(Pseudomonas
aeruginosa) 		4 / 5 VAL A 201
LEU A 338
LEU A 186
ILE A 177
 None
 0.92A 4a9jC-5ez7A:
undetectable		 4a9jC-5ez7A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5ez7 FLAVOENZYME PA4991
(Pseudomonas
aeruginosa) 		5 / 10 THR A   7
GLY A 188
VAL A  35
ILE A  11
VAL A  12
 None
None
None
None
FAD  A 401 (-4.7A)
 1.05A 4jx1B-5ez7A:
undetectable		 4jx1B-5ez7A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 5ez7 FLAVOENZYME PA4991
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 203
LEU A  10
ILE A 177
LEU A 216
LEU A 186
 None
 1.02A 4p65F-5ez7A:
undetectable
4p65H-5ez7A:
undetectable
4p65K-5ez7A:
undetectable
4p65L-5ez7A:
undetectable		 4p65F-5ez7A:
6.09
4p65H-5ez7A:
6.09
4p65K-5ez7A:
3.71
4p65L-5ez7A:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 5ez7 FLAVOENZYME PA4991
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 188
ILE A 196
SER A   6
LEU A 189
VAL A 201
 None
 1.00A 4qdjA-5ez7A:
undetectable		 4qdjA-5ez7A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5ez7 FLAVOENZYME PA4991
(Pseudomonas
aeruginosa) 		3 / 3 MET A 230
GLN A 287
ARG A 313
 FAD  A 401 (-3.6A)
None
None
 0.89A 5ewzB-5ez7A:
undetectable		 5ewzB-5ez7A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 5ez7 FLAVOENZYME PA4991
(Pseudomonas
aeruginosa) 		4 / 7 ASN A 209
GLY A 206
ALA A 205
GLY A  18
 None
FAD  A 401 (-3.8A)
FAD  A 401 (-3.7A)
None
 0.67A 5kqyB-5ez7A:
undetectable		 5kqyB-5ez7A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 5ez7 FLAVOENZYME PA4991
(Pseudomonas
aeruginosa) 		4 / 8 ASN A 209
GLY A 206
ALA A 205
GLY A  18
 None
FAD  A 401 (-3.8A)
FAD  A 401 (-3.7A)
None
 0.65A 5kr1B-5ez7A:
undetectable		 5kr1B-5ez7A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 5ez7 FLAVOENZYME PA4991
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 159
GLY A  18
GLY A  15
LEU A 166
ALA A  23
 None
None
FAD  A 401 (-3.3A)
None
None
 0.99A 5l0zB-5ez7A:
4.3		 5l0zB-5ez7A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5ez7 FLAVOENZYME PA4991
(Pseudomonas
aeruginosa) 		3 / 3 MET A 230
GLN A 287
ARG A 313
 FAD  A 401 (-3.6A)
None
None
 0.98A 5m35B-5ez7A:
undetectable		 5m35B-5ez7A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5ez7 FLAVOENZYME PA4991
(Pseudomonas
aeruginosa) 		3 / 3 MET A 230
GLN A 287
ARG A 313
 FAD  A 401 (-3.6A)
None
None
 0.99A 5m36A-5ez7A:
undetectable		 5m36A-5ez7A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 5ez7 FLAVOENZYME PA4991
(Pseudomonas
aeruginosa) 		5 / 11 VAL A  12
GLU A  36
SER A 204
LEU A 203
ASN A 209
 FAD  A 401 (-4.7A)
FAD  A 401 (-2.8A)
None
None
None
 1.21A 5x6yA-5ez7A:
undetectable		 5x6yA-5ez7A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 5ez7 FLAVOENZYME PA4991
(Pseudomonas
aeruginosa) 		5 / 11 VAL A  12
GLY A  13
GLU A  36
SER A 204
LEU A 203
 FAD  A 401 (-4.7A)
FAD  A 401 (-3.3A)
FAD  A 401 (-2.8A)
None
None
 1.08A 5x6yA-5ez7A:
undetectable		 5x6yA-5ez7A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 5ez7 FLAVOENZYME PA4991
(Pseudomonas
aeruginosa) 		5 / 10 VAL A  12
GLY A  13
GLU A  36
SER A 204
LEU A 203
 FAD  A 401 (-4.7A)
FAD  A 401 (-3.3A)
FAD  A 401 (-2.8A)
None
None
 1.10A 5x6yB-5ez7A:
undetectable		 5x6yB-5ez7A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 5ez7 FLAVOENZYME PA4991
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 238
LEU A 295
THR A 257
ARG A 313
 None
 1.09A 6ew0F-5ez7A:
undetectable		 6ew0F-5ez7A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5ez7 FLAVOENZYME PA4991
(Pseudomonas
aeruginosa) 		3 / 3 MET A 230
GLN A 287
ARG A 313
 FAD  A 401 (-3.6A)
None
None
 1.01A 6fn9A-5ez7A:
undetectable		 6fn9A-5ez7A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5ez7 FLAVOENZYME PA4991
(Pseudomonas
aeruginosa) 		3 / 3 MET A 230
GLN A 287
ARG A 313
 FAD  A 401 (-3.6A)
None
None
 0.99A 6fnaB-5ez7A:
undetectable		 6fnaB-5ez7A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5ez7 FLAVOENZYME PA4991
(Pseudomonas
aeruginosa) 		3 / 3 MET A 230
GLN A 287
ARG A 313
 FAD  A 401 (-3.6A)
None
None
 1.01A 6fnbA-5ez7A:
undetectable		 6fnbA-5ez7A:
21.99