SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ezb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 5ezb CHICKEN PRESTIN STAS
DOMAIN,CHICKEN
PRESTIN STAS DOMAIN
(Gallus
gallus) 		4 / 8 TYR A 514
PHE A 544
THR A 674
LEU A 550
 None
 1.17A 1ea1A-5ezbA:
undetectable		 1ea1A-5ezbA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 5ezb CHICKEN PRESTIN STAS
DOMAIN,CHICKEN
PRESTIN STAS DOMAIN
(Gallus
gallus) 		5 / 10 ILE A 679
PHE A 708
MET A 699
TYR A 558
LEU A 717
 None
 1.44A 2w98A-5ezbA:
undetectable		 2w98A-5ezbA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5ezb CHICKEN PRESTIN STAS
DOMAIN,CHICKEN
PRESTIN STAS DOMAIN
(Gallus
gallus) 		4 / 8 LEU A 675
VAL A 712
VAL A 689
LEU A 702
 None
 0.92A 3v81C-5ezbA:
undetectable		 3v81C-5ezbA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 5ezb CHICKEN PRESTIN STAS
DOMAIN,CHICKEN
PRESTIN STAS DOMAIN
(Gallus
gallus) 		5 / 12 TYR A 682
ILE A 679
VAL A 678
THR A 566
ILE A 691
 None
 1.15A 3vrjA-5ezbA:
undetectable
3vrjC-5ezbA:
undetectable		 3vrjA-5ezbA:
18.52
3vrjC-5ezbA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5ezb CHICKEN PRESTIN STAS
DOMAIN,CHICKEN
PRESTIN STAS DOMAIN
(Gallus
gallus) 		4 / 8 LEU A 675
VAL A 712
VAL A 689
LEU A 702
 None
 1.03A 4q0bA-5ezbA:
undetectable		 4q0bA-5ezbA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 5ezb CHICKEN PRESTIN STAS
DOMAIN,CHICKEN
PRESTIN STAS DOMAIN
(Gallus
gallus) 		4 / 8 TYR A 526
TYR A 538
ILE A 541
ILE A 516
 None
 0.78A 5mzrE-5ezbA:
undetectable		 5mzrE-5ezbA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 5ezb CHICKEN PRESTIN STAS
DOMAIN,CHICKEN
PRESTIN STAS DOMAIN
(Gallus
gallus) 		4 / 7 TYR A 558
THR A 566
VAL A 687
TYR A 682
 None
 1.14A 5ov9A-5ezbA:
undetectable		 5ov9A-5ezbA:
13.55