SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ezo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 5ezo C12 FAB
(Plasmodium
falciparum) 		4 / 7 SER A 201
ARG A 135
TYR A 144
LEU A  93
 None
 1.16A 1ibgL-5ezoA:
undetectable		 1ibgL-5ezoA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 5ezo C12 FAB
(Plasmodium
falciparum) 		5 / 12 VAL A 333
ILE A 343
LEU A 341
GLU A  38
ILE A  42
 None
 1.26A 2gj5A-5ezoA:
undetectable		 2gj5A-5ezoA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5ezo C12 FAB
(Plasmodium
falciparum) 		3 / 3 ASN A 254
HIS A 240
VAL A 283
 None
 0.82A 3elzB-5ezoA:
2.1		 3elzB-5ezoA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 5ezo C12 FAB
(Plasmodium
falciparum) 		4 / 8 GLY A 329
GLN A 281
THR A 331
SER A 345
 None
 1.05A 6eqpA-5ezoA:
undetectable		 6eqpA-5ezoA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5ezo C12 FAB
(Plasmodium
falciparum) 		4 / 8 ASP A 121
ARG A 102
HIS A 104
ASP A  67
 None
 0.97A 6mn4B-5ezoA:
undetectable		 6mn4B-5ezoA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5ezo C12 FAB
(Plasmodium
falciparum) 		4 / 8 ASP A 121
ARG A 102
HIS A 104
ASP A  67
 None
 1.17A 6mn4D-5ezoA:
undetectable		 6mn4D-5ezoA:
21.15