SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ezr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
5 / 12 ILE A 585
ILE A 653
ALA A 644
TYR A 647
GLU A 588
None
1.31A 1ki7B-5ezrA:
undetectable
1ki7B-5ezrA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
5 / 12 LEU A 664
LEU A 665
GLY A 616
THR A 611
ILE A 595
4ZS  A 901 (-3.6A)
None
None
4ZS  A 901 (-3.2A)
4ZS  A 901 (-4.3A)
1.44A 1p93A-5ezrA:
undetectable
1p93A-5ezrA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
5 / 12 ILE A 439
ALA A 487
ILE A 451
ILE A 438
THR A 486
None
1.12A 1re7A-5ezrA:
undetectable
1re7A-5ezrA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 6 ILE A 540
VAL A 548
ILE A 594
ILE A 653
4ZS  A 901 (-4.2A)
4ZS  A 901 (-4.8A)
None
None
0.77A 1uwhA-5ezrA:
20.0
1uwhA-5ezrA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 7 ILE A 540
LYS A 563
ILE A 594
ASP A 675
4ZS  A 901 (-4.2A)
4ZS  A 901 (-3.9A)
None
None
0.87A 1uwjA-5ezrA:
10.3
1uwjA-5ezrA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 7 ILE A 540
LYS A 563
ILE A 594
ILE A 653
4ZS  A 901 (-4.2A)
4ZS  A 901 (-3.9A)
None
None
0.87A 1uwjA-5ezrA:
10.3
1uwjA-5ezrA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 6 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.94A 1v54A-5ezrA:
2.9
1v54J-5ezrA:
undetectable
1v54A-5ezrA:
20.35
1v54J-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 6 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.96A 2dyrA-5ezrA:
undetectable
2dyrJ-5ezrA:
undetectable
2dyrA-5ezrA:
20.35
2dyrJ-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 6 ARG A 276
MET A 279
THR A 280
LEU A 283
None
1.01A 2dysA-5ezrA:
2.6
2dysJ-5ezrA:
undetectable
2dysA-5ezrA:
20.35
2dysJ-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 6 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.93A 2dysN-5ezrA:
undetectable
2dysW-5ezrA:
undetectable
2dysN-5ezrA:
20.35
2dysW-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 6 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.97A 2eijA-5ezrA:
undetectable
2eijJ-5ezrA:
undetectable
2eijA-5ezrA:
20.35
2eijJ-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 6 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.94A 2eilA-5ezrA:
undetectable
2eilJ-5ezrA:
undetectable
2eilA-5ezrA:
20.35
2eilJ-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 5 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.91A 2eimJ-5ezrA:
undetectable
2eimJ-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 5 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.96A 2eimW-5ezrA:
undetectable
2eimW-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 6 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.88A 2einN-5ezrA:
2.4
2einW-5ezrA:
undetectable
2einN-5ezrA:
20.35
2einW-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 4 LEU A 808
PRO A 807
LEU A 626
ARG A 624
None
1.20A 2hrcA-5ezrA:
undetectable
2hrcA-5ezrA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
5 / 10 ALA A 622
LEU A 665
SER A 640
ILE A 641
PHE A 722
None
1.09A 2w9hA-5ezrA:
undetectable
2w9hA-5ezrA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
7 / 12 ILE A 540
ARG A 542
VAL A 548
ALA A 561
ILE A 595
LEU A 613
LEU A 664
4ZS  A 901 (-4.2A)
None
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-4.7A)
4ZS  A 901 (-3.6A)
0.66A 2y7jA-5ezrA:
27.8
2y7jA-5ezrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
7 / 12 ILE A 540
VAL A 548
ALA A 561
ILE A 595
LEU A 613
GLU A 618
LEU A 664
4ZS  A 901 (-4.2A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-4.7A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-3.6A)
0.72A 2y7jA-5ezrA:
27.8
2y7jA-5ezrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
6 / 10 ILE A 540
VAL A 548
ALA A 561
ILE A 595
LEU A 613
ASP A 675
4ZS  A 901 (-4.2A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-4.7A)
None
0.67A 2y7jB-5ezrA:
27.7
2y7jB-5ezrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
6 / 10 ILE A 540
VAL A 548
ALA A 561
ILE A 595
LEU A 613
LEU A 664
4ZS  A 901 (-4.2A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-4.7A)
4ZS  A 901 (-3.6A)
0.51A 2y7jB-5ezrA:
27.7
2y7jB-5ezrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
6 / 10 ILE A 540
VAL A 548
ALA A 561
ILE A 595
LEU A 613
LEU A 664
4ZS  A 901 (-4.2A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-4.7A)
4ZS  A 901 (-3.6A)
0.49A 2y7jC-5ezrA:
27.8
2y7jC-5ezrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
6 / 10 ILE A 540
VAL A 548
ALA A 561
ILE A 595
LEU A 613
LEU A 664
4ZS  A 901 (-4.2A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-4.7A)
4ZS  A 901 (-3.6A)
0.57A 2y7jD-5ezrA:
27.3
2y7jD-5ezrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 6 ARG A 276
MET A 279
THR A 280
LEU A 283
None
1.02A 2zxwA-5ezrA:
undetectable
2zxwJ-5ezrA:
undetectable
2zxwA-5ezrA:
20.35
2zxwJ-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 5 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.88A 3ag1J-5ezrA:
undetectable
3ag1J-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 6 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.94A 3ag1N-5ezrA:
1.9
3ag1W-5ezrA:
undetectable
3ag1N-5ezrA:
20.35
3ag1W-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 5 ARG A 276
MET A 279
THR A 280
LEU A 283
None
1.07A 3ag2J-5ezrA:
undetectable
3ag2J-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 5 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.99A 3ag4J-5ezrA:
undetectable
3ag4J-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 6 ARG A 276
MET A 279
THR A 280
LEU A 283
None
1.01A 3asnA-5ezrA:
2.5
3asnJ-5ezrA:
undetectable
3asnA-5ezrA:
20.35
3asnJ-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 6 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.99A 3asoA-5ezrA:
3.0
3asoJ-5ezrA:
undetectable
3asoA-5ezrA:
20.35
3asoJ-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
5 / 9 ALA A 622
LEU A 665
SER A 640
ILE A 641
PHE A 722
None
1.26A 3freX-5ezrA:
undetectable
3freX-5ezrA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 4 LEU A 808
PRO A 807
LEU A 626
ARG A 624
None
1.12A 3hcoB-5ezrA:
undetectable
3hcoB-5ezrA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
5 / 12 ALA A 561
ILE A 595
THR A 611
LEU A 613
ASP A 675
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-4.7A)
None
0.75A 3hecA-5ezrA:
20.3
3hecA-5ezrA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
5 / 12 ALA A 561
LYS A 563
ILE A 595
THR A 611
LEU A 613
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-4.7A)
0.65A 3hecA-5ezrA:
20.3
3hecA-5ezrA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
5 / 12 VAL A 548
ALA A 561
LYS A 563
ILE A 595
THR A 611
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.2A)
0.72A 3hegA-5ezrA:
17.7
3hegA-5ezrA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
7 / 12 GLY A 541
VAL A 548
ALA A 561
LYS A 563
ILE A 595
VAL A 614
LEU A 664
4ZS  A 901 ( 4.5A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.8A)
4ZS  A 901 (-3.6A)
0.60A 3lxnA-5ezrA:
21.8
3lxnA-5ezrA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
6 / 12 GLY A 541
VAL A 548
ALA A 561
LYS A 563
ILE A 595
THR A 611
4ZS  A 901 ( 4.5A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.2A)
0.49A 3ohtA-5ezrA:
5.0
3ohtA-5ezrA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
6 / 12 GLY A 541
VAL A 548
ALA A 561
LYS A 563
ILE A 595
THR A 611
4ZS  A 901 ( 4.5A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.2A)
0.42A 3ohtB-5ezrA:
4.9
3ohtB-5ezrA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 8 VAL A 548
LYS A 563
ILE A 595
ILE A 674
4ZS  A 901 (-4.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.9A)
0.56A 3warA-5ezrA:
23.5
3warA-5ezrA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 6 ARG A 276
MET A 279
THR A 280
LEU A 283
None
1.06A 3wg7N-5ezrA:
3.0
3wg7W-5ezrA:
undetectable
3wg7N-5ezrA:
20.35
3wg7W-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 6 THR A 280
ARG A 348
ILE A 328
LEU A 300
None
0.90A 4ac9C-5ezrA:
undetectable
4ac9C-5ezrA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 6 THR A 280
ARG A 348
ILE A 328
LEU A 300
None
0.89A 4acaC-5ezrA:
undetectable
4acaC-5ezrA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 6 THR A 280
ARG A 348
ILE A 328
LEU A 300
None
0.87A 4acbC-5ezrA:
undetectable
4acbC-5ezrA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
6 / 12 VAL A 548
ALA A 561
ILE A 595
THR A 611
LEU A 664
ASP A 675
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-3.6A)
None
1.03A 4bkjB-5ezrA:
19.5
4bkjB-5ezrA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
5 / 12 LEU A 297
ASN A 298
LEU A 300
ALA A 301
ALA A 282
None
0.95A 4fn9A-5ezrA:
undetectable
4fn9A-5ezrA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
8 / 12 VAL A 548
ALA A 561
ILE A 595
ASP A 657
ASN A 662
LEU A 664
ILE A 674
ASP A 675
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
None
None
4ZS  A 901 (-3.6A)
4ZS  A 901 (-3.9A)
None
0.78A 4i41A-5ezrA:
25.3
4i41A-5ezrA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
8 / 12 VAL A 548
ALA A 561
ILE A 595
ASP A 657
LYS A 659
ASN A 662
LEU A 664
ILE A 674
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
None
None
None
4ZS  A 901 (-3.6A)
4ZS  A 901 (-3.9A)
0.82A 4i41A-5ezrA:
25.3
4i41A-5ezrA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
6 / 11 VAL A 548
ALA A 561
LYS A 563
LEU A 664
ILE A 674
ASP A 675
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.6A)
4ZS  A 901 (-3.9A)
None
0.67A 4iaaA-5ezrA:
25.4
4iaaA-5ezrA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
8 / 12 GLY A 541
VAL A 548
ALA A 561
LEU A 597
GLY A 617
GLU A 618
LEU A 664
ILE A 674
4ZS  A 901 ( 4.5A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
None
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-3.6A)
4ZS  A 901 (-3.9A)
0.68A 4ifgA-5ezrA:
22.7
4ifgA-5ezrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 7 ILE A 397
PHE A 292
LEU A 388
THR A 380
None
0.98A 4mmcA-5ezrA:
undetectable
4mmcA-5ezrA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 5 LEU A 658
LEU A 648
LEU A 715
ASN A 589
None
0.88A 4n09B-5ezrA:
undetectable
4n09B-5ezrA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
6 / 12 VAL A 548
ALA A 561
LYS A 563
THR A 611
LEU A 664
ASP A 675
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-3.6A)
None
0.78A 4r7iA-5ezrA:
18.3
4r7iA-5ezrA:
17.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
10 / 10 ILE A 540
ALA A 561
LYS A 563
THR A 586
ILE A 595
PHE A 609
THR A 611
LEU A 613
VAL A 614
LEU A 664
4ZS  A 901 (-4.2A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.4A)
4ZS  A 901 (-4.3A)
None
4ZS  A 901 (-3.2A)
4ZS  A 901 (-4.7A)
4ZS  A 901 (-3.8A)
4ZS  A 901 (-3.6A)
0.38A 4rz7A-5ezrA:
55.5
4rz7A-5ezrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 5 ASP A 204
VAL A 197
PHE A 207
GLY A 233
None
1.17A 4xp6A-5ezrA:
undetectable
4xp6A-5ezrA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
6 / 12 VAL A 548
ALA A 561
LYS A 563
THR A 611
ASP A 675
PHE A 676
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.2A)
None
4ZS  A 901 (-4.9A)
0.88A 4xv2A-5ezrA:
19.5
4xv2A-5ezrA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
5 / 12 ALA A 561
LYS A 563
THR A 611
ASP A 675
PHE A 676
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.2A)
None
4ZS  A 901 (-4.9A)
0.85A 4xv2B-5ezrA:
19.7
4xv2B-5ezrA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 5 ILE A 623
ILE A 663
TYR A 620
GLU A 661
None
1.25A 4zzcE-5ezrA:
undetectable
4zzcE-5ezrA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 7 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.92A 5b3sN-5ezrA:
undetectable
5b3sW-5ezrA:
undetectable
5b3sN-5ezrA:
20.35
5b3sW-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
5 / 12 VAL A 548
ALA A 561
LYS A 563
THR A 611
PHE A 676
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-4.9A)
0.79A 5cswA-5ezrA:
19.4
5cswA-5ezrA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
5 / 12 VAL A 548
ALA A 561
LYS A 563
THR A 611
PHE A 676
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-4.9A)
0.78A 5cswB-5ezrA:
19.5
5cswB-5ezrA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 5 ALA A 634
TYR A 637
GLY A 543
LEU A 664
None
None
None
4ZS  A 901 (-3.6A)
1.02A 5eslA-5ezrA:
undetectable
5eslA-5ezrA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 7 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.90A 5iy5N-5ezrA:
undetectable
5iy5W-5ezrA:
undetectable
5iy5N-5ezrA:
20.35
5iy5W-5ezrA:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
5 / 9 ILE A 540
GLY A 541
VAL A 548
ALA A 561
ILE A 595
4ZS  A 901 (-4.2A)
4ZS  A 901 ( 4.5A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
0.27A 5lw1B-5ezrA:
21.9
5lw1B-5ezrA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
5 / 10 GLY A 541
VAL A 548
ALA A 561
ILE A 595
LEU A 613
4ZS  A 901 ( 4.5A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-4.7A)
0.42A 5lw1E-5ezrA:
21.8
5lw1E-5ezrA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
3 / 3 GLU A 646
TYR A 647
ARG A 651
None
0.71A 5uunA-5ezrA:
undetectable
5uunA-5ezrA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
3 / 3 GLU A 646
TYR A 647
ARG A 651
None
0.75A 5uunB-5ezrA:
undetectable
5uunB-5ezrA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
5 / 10 ILE A 645
ILE A 712
LEU A 766
ILE A 663
ASN A 662
None
1.43A 5vkqA-5ezrA:
undetectable
5vkqD-5ezrA:
undetectable
5vkqA-5ezrA:
19.39
5vkqD-5ezrA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
5 / 10 ILE A 663
ASN A 662
ILE A 645
ILE A 712
LEU A 766
None
1.42A 5vkqA-5ezrA:
undetectable
5vkqB-5ezrA:
undetectable
5vkqA-5ezrA:
19.39
5vkqB-5ezrA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 9 TYR A 637
ILE A 641
ILE A 645
LEU A 648
None
0.71A 5vkqB-5ezrA:
undetectable
5vkqC-5ezrA:
undetectable
5vkqB-5ezrA:
19.39
5vkqC-5ezrA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
5 / 10 ILE A 663
ASN A 662
ILE A 645
ILE A 712
LEU A 766
None
1.42A 5vkqC-5ezrA:
undetectable
5vkqD-5ezrA:
undetectable
5vkqC-5ezrA:
19.39
5vkqD-5ezrA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 5 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.73A 5w97J-5ezrA:
undetectable
5w97J-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 5 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.84A 5wauJ-5ezrA:
undetectable
5wauJ-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 5 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.77A 5x19J-5ezrA:
undetectable
5x19J-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 5 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.87A 5x1bJ-5ezrA:
undetectable
5x1bJ-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 5 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.97A 5x1fW-5ezrA:
undetectable
5x1fW-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
7 / 12 VAL A 548
ALA A 561
LYS A 563
THR A 611
LEU A 613
LEU A 664
ASP A 675
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-4.7A)
4ZS  A 901 (-3.6A)
None
0.57A 5y80A-5ezrA:
23.5
5y80A-5ezrA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 7 VAL A 548
LYS A 563
ILE A 674
ASP A 675
4ZS  A 901 (-4.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.9A)
None
0.82A 5yf9B-5ezrA:
22.1
5yf9B-5ezrA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
5 / 9 VAL A 548
LYS A 563
ILE A 595
ILE A 674
ASP A 675
4ZS  A 901 (-4.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.9A)
None
0.82A 5yf9X-5ezrA:
22.4
5yf9X-5ezrA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 7 LYS A 563
ILE A 595
ILE A 674
ASP A 675
4ZS  A 901 (-3.9A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.9A)
None
0.60A 5ywmX-5ezrA:
22.3
5ywmX-5ezrA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 7 VAL A 548
LYS A 563
ILE A 595
ILE A 674
4ZS  A 901 (-4.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.9A)
0.41A 5ywmX-5ezrA:
22.3
5ywmX-5ezrA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 5 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.85A 5z86J-5ezrA:
undetectable
5z86J-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 6 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.90A 5z86N-5ezrA:
undetectable
5z86W-5ezrA:
undetectable
5z86N-5ezrA:
20.35
5z86W-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 6 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.92A 5zcoN-5ezrA:
2.0
5zcoW-5ezrA:
undetectable
5zcoN-5ezrA:
20.35
5zcoW-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
3 / 3 LYS A 563
LEU A 664
ASP A 675
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.6A)
None
0.84A 5zv2A-5ezrA:
18.3
5zv2A-5ezrA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
5 / 12 LEU A 715
LEU A 658
ILE A 594
ALA A 644
HIS A 649
None
1.29A 6n91A-5ezrA:
undetectable
6n91A-5ezrA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
5 / 12 LEU A 715
LEU A 658
ILE A 594
ALA A 644
HIS A 649
None
1.20A 6n91B-5ezrA:
undetectable
6n91B-5ezrA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 5 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.59A 6nknW-5ezrA:
undetectable
6nknW-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 7 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.84A 6nmfA-5ezrA:
undetectable
6nmfJ-5ezrA:
undetectable
6nmfA-5ezrA:
20.35
6nmfJ-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax)
4 / 7 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.76A 6nmpA-5ezrA:
undetectable
6nmpJ-5ezrA:
undetectable
6nmpA-5ezrA:
20.35
6nmpJ-5ezrA:
6.28