SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f0k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 5f0k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		5 / 11 PHE A  85
LEU A  81
ALA A  42
VAL A 114
LEU A  97
 None
None
None
None
EDO  A 501 (-4.7A)
 1.44A 1qabE-5f0kA:
undetectable		 1qabE-5f0kA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XPQ_C_SPMC921_1
(FMS1 PROTEIN)		 5f0k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		5 / 11 ASN A  37
LYS A  90
PHE A  85
LEU A  81
TYR A  76
 None
SO4  A 507 ( 3.5A)
None
None
GOL  A 506 (-3.5A)
 1.47A 1xpqC-5f0kA:
undetectable		 1xpqC-5f0kA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 5f0k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		4 / 5 VAL A 440
ASN A 443
VAL A 415
ILE A 460
 None
 1.08A 1z2bC-5f0kA:
undetectable		 1z2bC-5f0kA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFM_A_TOPA1290_1
(PTERIDINE REDUCTASE
1)		 5f0k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		5 / 9 PHE A 187
LEU A 224
LEU A 243
LEU A 247
TYR A 238
 None
 1.12A 2bfmA-5f0kA:
undetectable
2bfmD-5f0kA:
undetectable		 2bfmA-5f0kA:
21.80
2bfmD-5f0kA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 5f0k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		4 / 6 LEU A  53
MET A 190
MET A 197
LEU A 216
 None
 1.45A 2oz7A-5f0kA:
undetectable		 2oz7A-5f0kA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 5f0k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		4 / 8 VAL A 295
GLU A 288
ARG A 339
ALA A 287
 None
 1.14A 2v41G-5f0kA:
undetectable
2v41H-5f0kA:
undetectable		 2v41G-5f0kA:
19.12
2v41H-5f0kA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_1
(DIHYDROFOLATE
REDUCTASE)		 5f0k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		4 / 4 GLU A  78
GLN A 155
ASN A 151
ARG A 226
 None
 1.28A 2w3bA-5f0kA:
0.0		 2w3bA-5f0kA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5f0k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		4 / 7 LEU A 398
PHE A 380
LEU A 424
PHE A 425
 None
 0.98A 3ag2C-5f0kA:
undetectable		 3ag2C-5f0kA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5f0k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		5 / 12 ILE A 303
ALA A 307
ILE A 267
VAL A 332
LEU A 279
 None
 1.13A 3dzuA-5f0kA:
undetectable		 3dzuA-5f0kA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5f0k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		5 / 12 THR A 375
THR A 376
LEU A 350
ILE A 404
LEU A 424
 None
 1.18A 3gwxA-5f0kA:
undetectable		 3gwxA-5f0kA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC0_A_MIYA1204_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0)		 5f0k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		5 / 12 PHE A 380
PHE A 425
PRO A 405
THR A 376
LEU A 373
 None
 1.45A 4ac0A-5f0kA:
1.5		 4ac0A-5f0kA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5f0k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		5 / 12 VAL A 134
GLU A 189
LEU A 230
LEU A 227
ARG A 158
 None
 1.22A 5hnyB-5f0kA:
undetectable		 5hnyB-5f0kA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 5f0k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		3 / 3 MET A 180
GLU A 236
ARG A 237
 None
 0.98A 5tjyA-5f0kA:
undetectable		 5tjyA-5f0kA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 5f0k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		3 / 3 MET A 180
GLU A 236
ARG A 237
 None
 1.06A 5tjzA-5f0kA:
undetectable		 5tjzA-5f0kA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 5f0k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		3 / 3 SER A  62
LYS A  61
SER A  59
 None
 0.74A 6az3P-5f0kA:
undetectable		 6az3P-5f0kA:
11.01