SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f0l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5f0l VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26A
(Homo
sapiens) 		4 / 6 ARG B 127
ILE B 122
GLY B 123
ALA B 124
 EDO  B 411 (-4.9A)
None
EDO  B 410 ( 4.0A)
EDO  B 410 ( 4.1A)
 0.93A 1wmqA-5f0lB:
undetectable		 1wmqA-5f0lB:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5f0l VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26A
(Homo
sapiens) 		4 / 6 ARG B 127
ILE B 122
GLY B 123
ALA B 124
 EDO  B 411 (-4.9A)
None
EDO  B 410 ( 4.0A)
EDO  B 410 ( 4.1A)
 0.94A 1wmqB-5f0lB:
undetectable		 1wmqB-5f0lB:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5f0l VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26A
(Homo
sapiens) 		4 / 6 ARG B 127
ILE B 122
GLY B 123
ALA B 124
 EDO  B 411 (-4.9A)
None
EDO  B 410 ( 4.0A)
EDO  B 410 ( 4.1A)
 0.94A 1wpuA-5f0lB:
undetectable		 1wpuA-5f0lB:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5f0l VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26A
(Homo
sapiens) 		4 / 6 ARG B 127
ILE B 122
GLY B 123
ALA B 124
 EDO  B 411 (-4.9A)
None
EDO  B 410 ( 4.0A)
EDO  B 410 ( 4.1A)
 0.94A 1wpuB-5f0lB:
undetectable		 1wpuB-5f0lB:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5f0l VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26A
(Homo
sapiens) 		4 / 6 ARG B 127
ILE B 122
GLY B 123
ALA B 124
 EDO  B 411 (-4.9A)
None
EDO  B 410 ( 4.0A)
EDO  B 410 ( 4.1A)
 0.94A 1wrqA-5f0lB:
undetectable		 1wrqA-5f0lB:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5f0l VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26A
(Homo
sapiens) 		4 / 6 ARG B 127
ILE B 122
GLY B 123
ALA B 124
 EDO  B 411 (-4.9A)
None
EDO  B 410 ( 4.0A)
EDO  B 410 ( 4.1A)
 0.96A 1wrqB-5f0lB:
undetectable		 1wrqB-5f0lB:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 5f0l VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26A
(Homo
sapiens) 		3 / 3 ASP B 142
GLU B  94
TYR B 107
 None
EDO  B 409 (-3.3A)
None
 0.79A 1wsvA-5f0lB:
undetectable		 1wsvA-5f0lB:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 5f0l VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26A
(Homo
sapiens) 		4 / 6 LEU B 252
TYR B 185
ILE B 292
GLY B 193
 None
 0.95A 2du8B-5f0lB:
undetectable		 2du8B-5f0lB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 5f0l VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26A
(Homo
sapiens) 		5 / 9 ILE B 248
ILE B 195
LEU B 276
LEU B 274
TYR B 185
 None
 1.26A 3f78A-5f0lB:
undetectable		 3f78A-5f0lB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 5f0l VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26A
(Homo
sapiens) 		5 / 9 ILE B 248
ILE B 195
LEU B 276
LEU B 274
TYR B 185
 None
 1.24A 3f78B-5f0lB:
undetectable		 3f78B-5f0lB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5f0l VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26A
(Homo
sapiens) 		5 / 11 LEU B 149
TYR B  40
GLU B 146
LEU B 132
LEU B  18
 None
GOL  B 406 (-4.1A)
None
None
None
 0.72A 4wg0C-5f0lB:
undetectable
4wg0D-5f0lB:
undetectable
4wg0E-5f0lB:
undetectable		 4wg0C-5f0lB:
6.32
4wg0D-5f0lB:
6.32
4wg0E-5f0lB:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5f0l VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26A
(Homo
sapiens) 		5 / 11 LEU B  18
GLU B 146
LEU B 132
LEU B 149
TYR B  40
 None
None
None
None
GOL  B 406 (-4.1A)
 0.78A 4wg0F-5f0lB:
undetectable
4wg0G-5f0lB:
undetectable
4wg0H-5f0lB:
undetectable		 4wg0F-5f0lB:
6.32
4wg0G-5f0lB:
6.32
4wg0H-5f0lB:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5f0l VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26A
(Homo
sapiens) 		5 / 11 LEU B 149
TYR B  40
GLU B 146
LEU B 132
LEU B  18
 None
GOL  B 406 (-4.1A)
None
None
None
 0.70A 4wg0E-5f0lB:
undetectable
4wg0F-5f0lB:
undetectable
4wg0G-5f0lB:
undetectable		 4wg0E-5f0lB:
6.32
4wg0F-5f0lB:
6.32
4wg0G-5f0lB:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5f0l VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26A
(Homo
sapiens) 		5 / 11 LEU B  18
GLU B 146
LEU B 132
LEU B 149
TYR B  40
 None
None
None
None
GOL  B 406 (-4.1A)
 0.85A 4wg0H-5f0lB:
undetectable
4wg0I-5f0lB:
undetectable
4wg0J-5f0lB:
undetectable		 4wg0H-5f0lB:
6.32
4wg0I-5f0lB:
6.32
4wg0J-5f0lB:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5f0l VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26A
(Homo
sapiens) 		5 / 11 LEU B 149
TYR B  40
GLU B 146
LEU B 132
LEU B  18
 None
GOL  B 406 (-4.1A)
None
None
None
 0.75A 4wg0G-5f0lB:
undetectable
4wg0H-5f0lB:
undetectable
4wg0I-5f0lB:
undetectable		 4wg0G-5f0lB:
6.32
4wg0H-5f0lB:
6.32
4wg0I-5f0lB:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5f0l VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26A
(Homo
sapiens) 		5 / 11 LEU B 149
TYR B  40
GLU B 146
LEU B 132
LEU B  18
 None
GOL  B 406 (-4.1A)
None
None
None
 0.80A 4wg0K-5f0lB:
undetectable
4wg0L-5f0lB:
undetectable
4wg0M-5f0lB:
undetectable		 4wg0K-5f0lB:
6.32
4wg0L-5f0lB:
6.32
4wg0M-5f0lB:
6.32