SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f12'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 5f12 NAD(P)H
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		3 / 3 ALA A 161
VAL A 109
TRP A 127
 None
 0.70A 1c4dA-5f12A:
undetectable
1c4dB-5f12A:
undetectable		 1c4dA-5f12A:
6.15
1c4dB-5f12A:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 5f12 NAD(P)H
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		3 / 3 TRP A 127
ALA A 161
VAL A 109
 None
 0.75A 1c4dA-5f12A:
undetectable
1c4dB-5f12A:
undetectable		 1c4dA-5f12A:
6.15
1c4dB-5f12A:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 5f12 NAD(P)H
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		3 / 3 ALA A 161
VAL A 109
TRP A 127
 None
 0.89A 1c4dC-5f12A:
undetectable
1c4dD-5f12A:
undetectable		 1c4dC-5f12A:
6.15
1c4dD-5f12A:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 5f12 NAD(P)H
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		3 / 3 TRP A 127
ALA A 161
VAL A 109
 None
 0.86A 1c4dC-5f12A:
undetectable
1c4dD-5f12A:
undetectable		 1c4dC-5f12A:
6.15
1c4dD-5f12A:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 5f12 NAD(P)H
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		5 / 10 LEU A 178
ALA A 161
VAL A  21
ILE A  72
GLY A  74
 None
 1.14A 1d4sA-5f12A:
undetectable		 1d4sA-5f12A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5f12 NAD(P)H
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		4 / 6 GLY A 185
GLN A 184
VAL A   5
ALA A  22
 None
 0.97A 1p6kA-5f12A:
undetectable		 1p6kA-5f12A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 5f12 NAD(P)H
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		3 / 3 ASP A  69
TYR A  68
GLU A  32
 None
 0.84A 1vm1A-5f12A:
undetectable		 1vm1A-5f12A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 5f12 NAD(P)H
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		4 / 8 VAL A   3
PHE A 110
ALA A  18
GLN A 184
 None
 1.12A 2ij7C-5f12A:
undetectable		 2ij7C-5f12A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 5f12 NAD(P)H
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		5 / 12 LEU A 178
ALA A 161
ILE A  72
GLY A  74
ILE A  14
 None
None
None
None
FMN  A 201 (-3.9A)
 1.04A 3spkB-5f12A:
undetectable		 3spkB-5f12A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5f12 NAD(P)H
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		4 / 7 ASP A 149
ARG A 182
GLY A  24
GLU A  23
 None
 0.93A 5btfA-5f12A:
undetectable
5btfB-5f12A:
2.8
5btfC-5f12A:
undetectable		 5btfA-5f12A:
19.57
5btfB-5f12A:
20.99
5btfC-5f12A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 5f12 NAD(P)H
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		4 / 6 GLU A  40
GLY A 167
ASP A 168
GLY A 114
 MHO  A  10 ( 4.7A)
None
None
FMN  A 201 (-3.6A)
 0.95A 5cdpA-5f12A:
undetectable
5cdpB-5f12A:
3.6		 5cdpA-5f12A:
16.15
5cdpB-5f12A:
24.54