SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f1b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 5f1b GP1
(Zaire
ebolavirus) 		5 / 12 GLY A 149
ALA A 148
GLY A 145
ILE A 113
ALA A 152
 None
 0.85A 3n3iA-5f1bA:
undetectable		 3n3iA-5f1bA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5f1b GP1
(Zaire
ebolavirus) 		4 / 7 ASN A  69
GLU A 178
GLU A  71
ARG A  85
 None
 0.99A 4mi4B-5f1bA:
undetectable
4mi4C-5f1bA:
undetectable		 4mi4B-5f1bA:
21.61
4mi4C-5f1bA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5f1b GP1
(Zaire
ebolavirus) 		3 / 3 ALA A 166
TYR A 162
PRO A  94
 None
 0.68A 4zdyA-5f1bA:
undetectable		 4zdyA-5f1bA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5f1b GP1
(Zaire
ebolavirus) 		4 / 5 SER A 167
ARG A 172
GLY A 173
GLU A 112
 None
 1.12A 5btiC-5f1bA:
undetectable
5btiD-5f1bA:
undetectable		 5btiC-5f1bA:
17.78
5btiD-5f1bA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 5f1b GP1
(Zaire
ebolavirus) 		4 / 4 LEU A  70
LEU A 161
GLY A  67
GLU A 103
 None
 1.27A 5hhjA-5f1bA:
undetectable		 5hhjA-5f1bA:
18.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 5f1b GP1
(Zaire
ebolavirus) 		6 / 7 VAL A  66
LEU A  68
GLU A 100
ALA A 101
LEU A 184
LEU A 186
 None
 0.44A 5jq7A-5f1bA:
19.2		 5jq7A-5f1bA:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5f1b GP1
(Zaire
ebolavirus) 		4 / 7 GLU A 178
PHE A 176
ALA A 152
GLY A  87
 None
 1.05A 5uxdA-5f1bA:
undetectable		 5uxdA-5f1bA:
20.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 5f1b GP1
(Zaire
ebolavirus) 		5 / 12 ARG A  64
VAL A  66
LEU A  68
ALA A 101
GLY A 102
 None
 1.02A 6f6iA-5f1bA:
20.5
6f6iB-5f1bA:
undetectable		 6f6iA-5f1bA:
98.70
6f6iB-5f1bA:
21.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 5f1b GP1
(Zaire
ebolavirus) 		6 / 12 VAL A  66
LEU A  68
GLU A 100
ALA A 101
GLY A 102
LEU A 186
 None
 0.39A 6f6iA-5f1bA:
20.5
6f6iB-5f1bA:
undetectable		 6f6iA-5f1bA:
98.70
6f6iB-5f1bA:
21.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 5f1b GP1
(Zaire
ebolavirus) 		4 / 7 LEU A  43
VAL A  66
LEU A 184
LEU A 186
 None
 0.27A 6g9bA-5f1bA:
23.1
6g9bB-5f1bA:
undetectable		 6g9bA-5f1bA:
98.70
6g9bB-5f1bA:
21.12