SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f1n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 5f1n BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Canis
lupus) 		4 / 4 GLY B  56
ASP B  85
GLY A 120
THR A  10
 None
 1.06A 1hxbB-5f1nB:
undetectable		 1hxbB-5f1nB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 5f1n MHC CLASS I ANTIGEN
(Canis
lupus) 		3 / 3 ASP A 102
GLU A 213
TYR A 210
 None
 0.81A 1wsvA-5f1nA:
undetectable		 1wsvA-5f1nA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 5f1n MHC CLASS I ANTIGEN
(Canis
lupus) 		3 / 3 TRP A 168
GLU A  63
TYR A  59
 None
 1.07A 2a3aA-5f1nA:
undetectable		 2a3aA-5f1nA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5f1n MHC CLASS I ANTIGEN
BETA-2-MICROGLOBULIN
(Canis
lupus;
Canis
lupus) 		5 / 12 TYR A  85
LEU A  81
ALA A 140
ASP A 116
HIS B  58
 None
 1.36A 2qo4A-5f1nA:
1.7		 2qo4A-5f1nA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5f1n BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Canis
lupus) 		5 / 10 SER A  92
SER A  13
GLY A 120
ALA B  27
GLN B  29
 None
 1.27A 2x2iB-5f1nA:
undetectable		 2x2iB-5f1nA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5f1n BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Canis
lupus) 		5 / 10 VAL B 111
SER A  92
SER A  13
ALA B  27
GLN B  29
 None
 1.35A 2x2iB-5f1nB:
undetectable		 2x2iB-5f1nB:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5f1n BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Canis
lupus) 		6 / 12 VAL B 111
SER A  92
SER A  13
GLY A 120
ALA B  27
GLN B  29
 None
 1.31A 2x2iC-5f1nB:
undetectable		 2x2iC-5f1nB:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5f1n MHC CLASS I ANTIGEN
(Canis
lupus) 		4 / 8 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.92A 2zm8A-5f1nA:
undetectable		 2zm8A-5f1nA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5f1n MHC CLASS I ANTIGEN
(Canis
lupus) 		4 / 8 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.97A 2zmaA-5f1nA:
undetectable		 2zmaA-5f1nA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 5f1n BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Canis
lupus) 		5 / 12 ALA B  27
GLY B  56
THR A  10
VAL A  12
THR A  94
 None
 1.07A 3c6gA-5f1nB:
undetectable		 3c6gA-5f1nB:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 5f1n BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Canis
lupus) 		5 / 12 ALA B  27
GLY B  56
THR A  10
VAL A  12
THR A  94
 None
 1.10A 3c6gB-5f1nB:
undetectable		 3c6gB-5f1nB:
16.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UPR_A_1KXA277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5f1n MHC CLASS I ANTIGEN
(Canis
lupus) 		7 / 10 TYR A   9
TYR A  74
ILE A  95
TYR A  99
TYR A 123
ILE A 124
TRP A 147
 None
 0.38A 3uprA-5f1nA:
33.4		 3uprA-5f1nA:
80.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UPR_C_1KXC277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5f1n MHC CLASS I ANTIGEN
(Canis
lupus) 		7 / 10 TYR A   9
TYR A  74
ILE A  95
TYR A  99
TYR A 123
ILE A 124
TRP A 147
 None
 0.34A 3uprC-5f1nA:
33.6		 3uprC-5f1nA:
80.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRI_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 5f1n MHC CLASS I ANTIGEN
(Canis
lupus) 		6 / 10 TYR A   9
TYR A  74
TYR A  99
TYR A 123
ILE A 124
TRP A 147
 None
 0.32A 3vriA-5f1nA:
33.9
3vriC-5f1nA:
undetectable		 3vriA-5f1nA:
80.73
3vriC-5f1nA:
7.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 5f1n MHC CLASS I ANTIGEN
(Canis
lupus) 		7 / 12 TYR A   9
TYR A  74
ILE A  95
TYR A  99
TYR A 123
ILE A 124
TRP A 147
 None
 0.29A 3vrjA-5f1nA:
33.8
3vrjC-5f1nA:
undetectable		 3vrjA-5f1nA:
80.73
3vrjC-5f1nA:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 5f1n MHC CLASS I ANTIGEN
(Canis
lupus) 		4 / 6 ARG A  82
ARG A  75
ASP A  79
VAL A  12
 None
 1.37A 4xqeA-5f1nA:
undetectable		 4xqeA-5f1nA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5f1n MHC CLASS I ANTIGEN
(Canis
lupus) 		4 / 6 ARG A  82
ARG A  75
ASP A  79
VAL A  12
 None
 1.38A 4xqeB-5f1nA:
undetectable		 4xqeB-5f1nA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 5f1n MHC CLASS I ANTIGEN
(Canis
lupus) 		4 / 7 ASP A 239
THR A 241
TYR A 210
THR A 179
 None
 1.22A 5b6iA-5f1nA:
undetectable		 5b6iA-5f1nA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 5f1n MHC CLASS I ANTIGEN
(Canis
lupus) 		4 / 6 ASP A 239
THR A 241
TYR A 210
THR A 179
 None
 1.21A 5b6iB-5f1nA:
undetectable		 5b6iB-5f1nA:
22.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 5f1n MHC CLASS I ANTIGEN
(Canis
lupus) 		3 / 3 PRO A  47
ARG A  48
GLU A  53
 None
 1.00A 5j6hA-5f1nA:
33.2		 5j6hA-5f1nA:
73.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5f1n MHC CLASS I ANTIGEN
(Canis
lupus) 		4 / 4 GLN A 219
THR A 217
THR A 188
LEU A 267
 None
 1.44A 5m5kA-5f1nA:
undetectable		 5m5kA-5f1nA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5f1n MHC CLASS I ANTIGEN
(Canis
lupus) 		4 / 4 GLN A 219
THR A 217
THR A 188
LEU A 267
 None
 1.40A 5m66B-5f1nA:
undetectable		 5m66B-5f1nA:
18.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5U98_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5f1n MHC CLASS I ANTIGEN
(Canis
lupus) 		7 / 10 TYR A   9
TYR A  74
ILE A  95
TYR A  99
TYR A 123
ILE A 124
TRP A 147
 None
 0.34A 5u98A-5f1nA:
33.9		 5u98A-5f1nA:
80.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5U98_D_1KXD301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5f1n MHC CLASS I ANTIGEN
(Canis
lupus) 		7 / 10 TYR A   9
TYR A  74
ILE A  95
TYR A  99
TYR A 123
ILE A 124
TRP A 147
 None
 0.33A 5u98D-5f1nA:
33.8		 5u98D-5f1nA:
80.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 5f1n MHC CLASS I ANTIGEN
(Canis
lupus) 		4 / 5 LEU A  81
THR A  97
ARG A  75
PRO A  20
 None
 1.25A 6ew0B-5f1nA:
undetectable		 6ew0B-5f1nA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 5f1n MHC CLASS I ANTIGEN
(Canis
lupus) 		4 / 5 LEU A  81
THR A  97
ARG A  75
PRO A  20
 None
 1.25A 6ew0D-5f1nA:
undetectable		 6ew0D-5f1nA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 5f1n MHC CLASS I ANTIGEN
(Canis
lupus) 		4 / 5 LEU A  81
THR A  97
ARG A  75
PRO A  20
 None
 1.25A 6ew0H-5f1nA:
undetectable		 6ew0H-5f1nA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 5f1n MHC CLASS I ANTIGEN
(Canis
lupus) 		4 / 5 LEU A  81
THR A  97
ARG A  75
PRO A  20
 None
 1.25A 6ew0I-5f1nA:
undetectable		 6ew0I-5f1nA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_2
(-)		 5f1n MHC CLASS I ANTIGEN
(Canis
lupus) 		4 / 4 GLN A 219
THR A 217
THR A 188
LEU A 267
 None
 1.40A 6f3mB-5f1nA:
undetectable		 6f3mB-5f1nA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5f1n MHC CLASS I ANTIGEN
(Canis
lupus) 		4 / 5 ALA A 135
TYR A 123
GLN A 141
ILE A 142
 None
 1.39A 6f6sA-5f1nA:
undetectable
6f6sB-5f1nA:
undetectable		 6f6sA-5f1nA:
16.54
6f6sB-5f1nA:
15.27