SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f2o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		5 / 12 ALA A  66
PHE A 104
LEU A 107
ALA A 106
ILE A 138
 SAH  A 400 (-3.3A)
None
None
None
None
 0.89A 1fm6U-5f2oA:
undetectable		 1fm6U-5f2oA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		5 / 9 LEU A  72
SER A  71
VAL A  65
LEU A 107
ALA A 127
 None
SAH  A 400 ( 4.8A)
None
None
None
 1.39A 1fo4A-5f2oA:
undetectable		 1fo4A-5f2oA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		4 / 5 ASP A  98
VAL A  99
SER A 133
ASP A  62
 SAH  A 400 (-2.8A)
SAH  A 400 (-4.3A)
SAH  A 400 (-3.0A)
None
 1.32A 1n2xB-5f2oA:
11.1		 1n2xB-5f2oA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		4 / 6 TYR A  63
GLU A 202
PRO A 140
VAL A  59
 None
 1.27A 1q13A-5f2oA:
undetectable		 1q13A-5f2oA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		5 / 12 ALA A  66
PHE A 104
LEU A 107
ALA A 106
ILE A 138
 SAH  A 400 (-3.3A)
None
None
None
None
 1.02A 2aclA-5f2oA:
undetectable
2aclE-5f2oA:
undetectable		 2aclA-5f2oA:
23.85
2aclE-5f2oA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		4 / 6 LEU A 231
MET A 227
LEU A 348
GLU A 341
 None
 1.16A 2kuhA-5f2oA:
undetectable		 2kuhA-5f2oA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		5 / 11 SER A 149
LEU A 264
ILE A 153
ALA A 154
LEU A 359
 None
None
None
5UF  A 401 ( 4.9A)
None
 1.44A 2v0mA-5f2oA:
undetectable		 2v0mA-5f2oA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		4 / 7 SER A 125
LEU A  72
ILE A  79
GLY A  68
 None
 0.97A 2v0mC-5f2oA:
undetectable		 2v0mC-5f2oA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		4 / 7 PHE A 222
TYR A 224
ALA A 258
ALA A 154
 None
5UF  A 401 ( 4.3A)
None
5UF  A 401 ( 4.9A)
 0.86A 2wx2A-5f2oA:
undetectable		 2wx2A-5f2oA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		4 / 7 SER A  71
HIS A  96
THR A 110
LEU A 111
 SAH  A 400 ( 4.8A)
None
None
None
 1.08A 3arrA-5f2oA:
undetectable		 3arrA-5f2oA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		5 / 11 ALA A  66
PHE A 104
LEU A 107
ALA A 106
ILE A 138
 SAH  A 400 (-3.3A)
None
None
None
None
 0.87A 3fc6A-5f2oA:
undetectable		 3fc6A-5f2oA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_1
(O-METHYLTRANSFERASE)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		4 / 4 ASP A  98
SER A 133
PHE A 134
SER A 150
 SAH  A 400 (-2.8A)
SAH  A 400 (-3.0A)
SAH  A 400 (-3.3A)
SAH  A 400 (-2.7A)
 0.80A 3i5uA-5f2oA:
13.7		 3i5uA-5f2oA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		4 / 8 PHE A 222
TYR A 224
ALA A 258
ALA A 154
 None
5UF  A 401 ( 4.3A)
None
5UF  A 401 ( 4.9A)
 0.87A 3khmA-5f2oA:
undetectable		 3khmA-5f2oA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		4 / 8 GLY A  64
PHE A 274
PHE A 268
PHE A 195
 SAH  A 400 (-3.8A)
None
None
None
 1.07A 3ko0D-5f2oA:
undetectable
3ko0E-5f2oA:
undetectable		 3ko0D-5f2oA:
13.62
3ko0E-5f2oA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		4 / 8 PHE A 195
GLY A  64
PHE A 274
PHE A 268
 None
SAH  A 400 (-3.8A)
None
None
 1.06A 3ko0B-5f2oA:
undetectable
3ko0J-5f2oA:
undetectable		 3ko0B-5f2oA:
13.62
3ko0J-5f2oA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		4 / 7 GLY A  64
PHE A 274
PHE A 268
PHE A 195
 SAH  A 400 (-3.8A)
None
None
None
 1.01A 3ko0L-5f2oA:
undetectable
3ko0N-5f2oA:
undetectable		 3ko0L-5f2oA:
13.62
3ko0N-5f2oA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		4 / 7 PHE A 195
GLY A  64
PHE A 274
PHE A 268
 None
SAH  A 400 (-3.8A)
None
None
 1.02A 3ko0K-5f2oA:
undetectable
3ko0S-5f2oA:
undetectable		 3ko0K-5f2oA:
13.62
3ko0S-5f2oA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		4 / 7 PHE A 195
GLY A  64
PHE A 274
PHE A 268
 None
SAH  A 400 (-3.8A)
None
None
 1.08A 3ko0R-5f2oA:
undetectable
3ko0T-5f2oA:
undetectable		 3ko0R-5f2oA:
13.62
3ko0T-5f2oA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		4 / 8 PHE A 222
TYR A 224
ALA A 258
ALA A 154
 None
5UF  A 401 ( 4.3A)
None
5UF  A 401 ( 4.9A)
 0.64A 3l4dD-5f2oA:
undetectable		 3l4dD-5f2oA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_A_SALA1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		5 / 9 LEU A  72
SER A  71
VAL A  65
LEU A 107
ALA A 127
 None
SAH  A 400 ( 4.8A)
None
None
None
 1.41A 3unaA-5f2oA:
undetectable		 3unaA-5f2oA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		5 / 9 LEU A  72
SER A  71
VAL A  65
LEU A 107
ALA A 127
 None
SAH  A 400 ( 4.8A)
None
None
None
 1.41A 3unaB-5f2oA:
undetectable		 3unaB-5f2oA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		5 / 9 LEU A  72
SER A  71
VAL A  65
LEU A 107
ALA A 127
 None
SAH  A 400 ( 4.8A)
None
None
None
 1.41A 3uncA-5f2oA:
undetectable		 3uncA-5f2oA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		5 / 9 LEU A  72
SER A  71
VAL A  65
LEU A 107
ALA A 127
 None
SAH  A 400 ( 4.8A)
None
None
None
 1.40A 3uncB-5f2oA:
undetectable		 3uncB-5f2oA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		5 / 9 PRO A 160
GLY A 162
ALA A 163
ASP A 177
LEU A 166
 None
 1.45A 3ur0C-5f2oA:
undetectable		 3ur0C-5f2oA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		5 / 12 VAL A 211
ILE A 138
ILE A 153
ARG A 201
LEU A 364
 None
 0.99A 4iv0A-5f2oA:
15.0		 4iv0A-5f2oA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		5 / 12 VAL A 211
ILE A 138
ILE A 153
ARG A 201
LEU A 364
 None
 1.02A 4mwzB-5f2oA:
14.3		 4mwzB-5f2oA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		4 / 5 ILE A  60
SER A  71
HIS A  96
ASP A 122
 None
SAH  A 400 ( 4.8A)
None
None
 1.23A 4rzvB-5f2oA:
undetectable		 4rzvB-5f2oA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		5 / 12 PHE A 336
PHE A 222
TYR A 224
ALA A 258
ALA A 154
 None
None
5UF  A 401 ( 4.3A)
None
5UF  A 401 ( 4.9A)
 1.10A 5tl8A-5f2oA:
undetectable		 5tl8A-5f2oA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		5 / 12 ALA A  66
PHE A 104
LEU A 107
ALA A 106
ILE A 138
 SAH  A 400 (-3.3A)
None
None
None
None
 0.91A 6a5zL-5f2oA:
undetectable		 6a5zL-5f2oA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 5f2o FATTY ACID
O-METHYLTRANSFERASE
(Mycobacterium
marinum) 		5 / 9 ASP A  98
LEU A 139
ALA A  95
VAL A  94
ASP A  62
 SAH  A 400 (-2.8A)
None
None
None
None
 1.36A 6c2mB-5f2oA:
undetectable		 6c2mB-5f2oA:
13.86