SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f38'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		4 / 4 LEU B 359
PRO B 272
ILE B 259
LEU B 257
 None
 0.86A 1ya4B-5f38B:
undetectable		 1ya4B-5f38B:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		4 / 4 LEU B 359
PRO B 272
ILE B 259
LEU B 257
 None
 0.92A 1ya4C-5f38B:
undetectable		 1ya4C-5f38B:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 ILE B 358
LEU B 359
GLY B  91
ALA B 387
ALA B 376
 None
 0.99A 2oc8A-5f38B:
undetectable		 2oc8A-5f38B:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 GLY B 348
SER B 248
ALA B 344
ASN B 317
GLY B  91
 None
COZ  B 401 (-3.9A)
None
None
None
 1.13A 2vmyB-5f38B:
undetectable		 2vmyB-5f38B:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		4 / 5 ARG B  11
ASP B 217
ILE B 191
GLU B 199
 None
 0.82A 2xrzA-5f38B:
undetectable
2xrzB-5f38B:
undetectable		 2xrzA-5f38B:
23.11
2xrzB-5f38B:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 9 ALA B 353
GLY B 113
ILE B  27
LEU B  29
ALA B 254
 None
None
EDO  B 405 ( 4.2A)
None
None
 0.92A 2z0yB-5f38B:
undetectable		 2z0yB-5f38B:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		6 / 9 VAL B 111
GLY B  54
GLY B 114
ILE B  34
LEU B  70
ALA B  66
 None
 1.39A 2z0yB-5f38B:
undetectable		 2z0yB-5f38B:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 PHE B 236
HIS B 157
PHE B 320
SER B 248
LEU B 145
 COZ  B 401 (-4.4A)
COZ  B 401 (-4.6A)
COZ  B 401 (-4.6A)
COZ  B 401 (-3.9A)
None
 1.39A 3u9fJ-5f38B:
undetectable
3u9fL-5f38B:
undetectable		 3u9fJ-5f38B:
18.72
3u9fL-5f38B:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVY_B_TOYB201_1
(AMINOGLYCOSIDE
N(6')-ACETYLTRANSFER
ASE TYPE 1)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 10 ASN B 339
GLU B 318
ASP B 217
GLU B 199
GLY B 355
 None
None
None
None
CSX  B  88 ( 4.3A)
 1.47A 4evyA-5f38B:
undetectable
4evyB-5f38B:
undetectable		 4evyA-5f38B:
18.73
4evyB-5f38B:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 ILE B 314
LEU B 331
GLY B 332
VAL B 327
ALA B 326
 None
 1.24A 4foxD-5f38B:
undetectable		 4foxD-5f38B:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 9 ALA B 387
THR B 297
ALA B 300
ILE B 380
GLY B 292
 None
None
None
MLY  B  86 ( 3.7A)
None
 1.12A 4qvqK-5f38B:
undetectable
4qvqL-5f38B:
undetectable		 4qvqK-5f38B:
20.89
4qvqL-5f38B:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 9 ALA B 387
THR B 297
ALA B 300
ILE B 380
GLY B 292
 None
None
None
MLY  B  86 ( 3.7A)
None
 1.12A 4qvqY-5f38B:
undetectable
4qvqZ-5f38B:
undetectable		 4qvqY-5f38B:
20.89
4qvqZ-5f38B:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 9 ALA B 112
ILE B 386
GLY B 355
ALA B 356
ILE B 259
 None
MLY  B  86 ( 4.8A)
CSX  B  88 ( 4.3A)
None
None
 1.04A 4r21B-5f38B:
undetectable		 4r21B-5f38B:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 GLU B 318
LEU B 375
GLY B 355
ALA B 353
GLU B 116
 None
None
CSX  B  88 ( 4.3A)
None
None
 1.29A 4retC-5f38B:
undetectable		 4retC-5f38B:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_B_QDNB602_1
(CYTOCHROME P450 2D6)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 9 LEU B 378
PHE B 320
ALA B 344
SER B 248
ALA B 247
 CSX  B  88 ( 4.0A)
COZ  B 401 (-4.6A)
None
COZ  B 401 (-3.9A)
COZ  B 401 ( 4.4A)
 1.40A 4wnuB-5f38B:
undetectable		 4wnuB-5f38B:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 VAL B  95
LEU B  92
ILE B 259
ILE B 390
GLY B 374
 None
 0.97A 4y8wC-5f38B:
undetectable		 4y8wC-5f38B:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 ILE B 102
VAL B 258
ALA B 255
ALA B 256
GLY B 355
 None
None
None
None
CSX  B  88 ( 4.3A)
 1.47A 5igpA-5f38B:
undetectable		 5igpA-5f38B:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU B  29
ASP B 217
ASN B 251
ALA B  22
ASN B 117
 None
None
None
EDO  B 403 (-3.6A)
None
 1.48A 5kc4A-5f38B:
undetectable		 5kc4A-5f38B:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		4 / 6 PHE B 320
THR B 161
ASP B 237
GLY B 240
 COZ  B 401 (-4.6A)
None
None
None
 1.22A 5mraA-5f38B:
undetectable
5mraB-5f38B:
undetectable		 5mraA-5f38B:
17.60
5mraB-5f38B:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		4 / 5 ILE B 110
PHE B  82
SER B  94
ALA B 101
 None
 1.07A 5msdA-5f38B:
undetectable		 5msdA-5f38B:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 GLY B 348
ASN B 246
GLN B 176
LEU B 179
LEU B 325
 None
 1.11A 5nwwA-5f38B:
undetectable		 5nwwA-5f38B:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHD_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 GLN B 184
ARG B 357
PRO B 350
ASN B 251
ILE B  14
 COZ  B 401 ( 4.7A)
None
None
None
None
 1.23A 5uhdC-5f38B:
0.0		 5uhdC-5f38B:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 ASN B  55
ASP B  28
GLY B  30
ALA B  31
LEU B  75
 None
EDO  B 405 (-3.1A)
None
None
None
 0.99A 5xxiA-5f38B:
undetectable		 5xxiA-5f38B:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		4 / 7 ASP B 217
ARG B 357
GLU B 199
GLU B 315
 None
 1.23A 6mn5E-5f38B:
undetectable		 6mn5E-5f38B:
11.90