SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f4b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5f4b NAD(P)H
DEHYDROGENASE
(QUINONE)
(Brucella
abortus) 		5 / 12 GLY A  29
ILE A 193
GLY A  25
ALA A  31
VAL A   2
 None
 0.96A 1jg2A-5f4bA:
2.5		 1jg2A-5f4bA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5f4b NAD(P)H
DEHYDROGENASE
(QUINONE)
(Brucella
abortus) 		4 / 6 GLY A 187
GLN A 186
VAL A   6
ALA A  23
 None
 0.98A 1p6kA-5f4bA:
undetectable		 1p6kA-5f4bA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5f4b NAD(P)H
DEHYDROGENASE
(QUINONE)
(Brucella
abortus) 		4 / 5 GLY A  29
GLY A  30
MET A   1
GLU A  28
 None
 1.17A 4fglC-5f4bA:
10.6		 4fglC-5f4bA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 5f4b NAD(P)H
DEHYDROGENASE
(QUINONE)
(Brucella
abortus) 		4 / 7 GLY A 120
ALA A 121
GLU A 122
SER A 127
 None
 0.78A 4r1zB-5f4bA:
undetectable		 4r1zB-5f4bA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 5f4b NAD(P)H
DEHYDROGENASE
(QUINONE)
(Brucella
abortus) 		4 / 6 LYS A  88
TYR A   9
ALA A  77
ARG A  79
 None
None
CL  A 202 (-3.6A)
None
 1.13A 4yshB-5f4bA:
undetectable		 4yshB-5f4bA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 5f4b NAD(P)H
DEHYDROGENASE
(QUINONE)
(Brucella
abortus) 		5 / 12 MET A  87
VAL A  38
PHE A  90
GLU A  65
THR A  94
 None
None
None
None
FMN  A 201 (-4.4A)
 1.27A 5w8aA-5f4bA:
undetectable		 5w8aA-5f4bA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5f4b NAD(P)H
DEHYDROGENASE
(QUINONE)
(Brucella
abortus) 		3 / 3 ARG A 173
LYS A 173
ARG A 184
 None
 0.97A 6c06D-5f4bA:
undetectable		 6c06D-5f4bA:
undetectable