SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5f4e SPERM-EGG FUSION
PROTEIN JUNO
(Homo
sapiens) 		4 / 7 LEU B 207
ALA B 223
ILE B  26
PRO B 105
 None
 0.99A 1oniB-5f4eB:
undetectable
1oniC-5f4eB:
undetectable		 1oniB-5f4eB:
19.38
1oniC-5f4eB:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 5f4e IZUMO SPERM-EGG
FUSION PROTEIN 1
(Homo
sapiens) 		3 / 3 ASP A  93
GLU A 120
SER A 100
 None
 0.75A 3p2kA-5f4eA:
undetectable		 3p2kA-5f4eA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 5f4e IZUMO SPERM-EGG
FUSION PROTEIN 1
(Homo
sapiens) 		3 / 3 ASN A 239
ALA A 158
ARG A 160
 None
 0.74A 3tj7C-5f4eA:
undetectable
3tj7D-5f4eA:
undetectable		 3tj7C-5f4eA:
21.29
3tj7D-5f4eA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 5f4e IZUMO SPERM-EGG
FUSION PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A  89
LEU A  90
PHE A  64
TYR A 125
 None
 1.04A 4j7uD-5f4eA:
undetectable		 4j7uD-5f4eA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5f4e IZUMO SPERM-EGG
FUSION PROTEIN 1
(Homo
sapiens) 		3 / 3 HIS A 157
SER A 190
ASN A 239
 None
 0.89A 5cprB-5f4eA:
undetectable		 5cprB-5f4eA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5f4e IZUMO SPERM-EGG
FUSION PROTEIN 1
SPERM-EGG FUSION
PROTEIN JUNO
(Homo
sapiens) 		4 / 7 PHE B  77
VAL A  77
ARG B  87
TRP A 148
 None
 1.21A 6av6C-5f4eB:
undetectable
6av6D-5f4eB:
undetectable		 6av6C-5f4eB:
18.54
6av6D-5f4eB:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5f4e IZUMO SPERM-EGG
FUSION PROTEIN 1
(Homo
sapiens) 		4 / 7 ASP A  79
GLN A 144
GLN A 130
TYR A  74
 None
 1.48A 6g31G-5f4eA:
2.0		 6g31G-5f4eA:
15.48