SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f4j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 5f4j PROTRUDING DOMAIN OF
GII.17 NOROVIRUS
CAPSID
(Norwalk
virus) 		5 / 11 ILE A 458
PHE A 434
LEU A 229
PRO A 230
ILE A 497
 None
None
None
EDO  A 601 ( 4.8A)
None
 1.00A 1dg5A-5f4jA:
undetectable		 1dg5A-5f4jA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 5f4j PROTRUDING DOMAIN OF
GII.17 NOROVIRUS
CAPSID
(Norwalk
virus) 		4 / 6 LEU A 432
MET A 530
LEU A 527
HIS A 501
 None
 1.26A 1errB-5f4jA:
undetectable		 1errB-5f4jA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5f4j PROTRUDING DOMAIN OF
GII.17 NOROVIRUS
CAPSID
(Norwalk
virus) 		4 / 8 SER A 357
GLN A 362
PHE A 363
ASP A 300
 None
 1.33A 1rs7B-5f4jA:
undetectable		 1rs7B-5f4jA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 5f4j PROTRUDING DOMAIN OF
GII.17 NOROVIRUS
CAPSID
(Norwalk
virus) 		5 / 12 PHE A 329
VAL A 438
THR A 275
LEU A 405
TYR A 408
 None
 1.17A 2cbrA-5f4jA:
undetectable		 2cbrA-5f4jA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 5f4j PROTRUDING DOMAIN OF
GII.17 NOROVIRUS
CAPSID
(Norwalk
virus) 		4 / 6 ASP A 471
ARG A 493
ASP A 269
THR A 267
 None
 1.26A 2j2pE-5f4jA:
undetectable
2j2pF-5f4jA:
undetectable		 2j2pE-5f4jA:
18.35
2j2pF-5f4jA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 5f4j PROTRUDING DOMAIN OF
GII.17 NOROVIRUS
CAPSID
(Norwalk
virus) 		5 / 12 LEU A 249
LEU A 237
ILE A 458
GLY A 264
LEU A 452
 None
 1.17A 2j7xA-5f4jA:
undetectable		 2j7xA-5f4jA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5f4j PROTRUDING DOMAIN OF
GII.17 NOROVIRUS
CAPSID
(Norwalk
virus) 		4 / 4 SER A 445
GLY A 447
HIS A 398
ASP A 300
 None
 1.05A 2oxtC-5f4jA:
undetectable		 2oxtC-5f4jA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5f4j PROTRUDING DOMAIN OF
GII.17 NOROVIRUS
CAPSID
(Norwalk
virus) 		4 / 6 ILE A 497
ARG A 265
THR A 267
LEU A 268
 None
 0.96A 3ag1N-5f4jA:
undetectable
3ag1W-5f4jA:
undetectable		 3ag1N-5f4jA:
20.83
3ag1W-5f4jA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5f4j PROTRUDING DOMAIN OF
GII.17 NOROVIRUS
CAPSID
(Norwalk
virus) 		5 / 12 VAL A 294
GLY A 335
ALA A 354
ALA A 351
ASP A 378
 None
 1.06A 3sugA-5f4jA:
undetectable		 3sugA-5f4jA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 5f4j PROTRUDING DOMAIN OF
GII.17 NOROVIRUS
CAPSID
(Norwalk
virus) 		4 / 5 VAL A 499
LEU A 507
VAL A 509
PHE A 487
 None
 0.91A 4lb0B-5f4jA:
undetectable		 4lb0B-5f4jA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5f4j PROTRUDING DOMAIN OF
GII.17 NOROVIRUS
CAPSID
(Norwalk
virus) 		4 / 5 PHE A 334
PRO A 389
VAL A 390
PHE A 242
 None
 1.20A 4w5oA-5f4jA:
undetectable		 4w5oA-5f4jA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5f4j PROTRUDING DOMAIN OF
GII.17 NOROVIRUS
CAPSID
(Norwalk
virus) 		4 / 5 PHE A 334
PRO A 389
VAL A 390
PHE A 242
 None
 1.20A 4z4cA-5f4jA:
undetectable		 4z4cA-5f4jA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5f4j PROTRUDING DOMAIN OF
GII.17 NOROVIRUS
CAPSID
(Norwalk
virus) 		4 / 5 PHE A 334
PRO A 389
VAL A 390
PHE A 242
 None
 1.22A 4z4dA-5f4jA:
undetectable		 4z4dA-5f4jA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5f4j PROTRUDING DOMAIN OF
GII.17 NOROVIRUS
CAPSID
(Norwalk
virus) 		4 / 5 PHE A 334
PRO A 389
VAL A 390
PHE A 242
 None
 1.21A 4z4eA-5f4jA:
undetectable		 4z4eA-5f4jA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 5f4j PROTRUDING DOMAIN OF
GII.17 NOROVIRUS
CAPSID
(Norwalk
virus) 		5 / 12 LEU A 249
LEU A 237
ILE A 458
GLY A 264
LEU A 452
 None
 1.17A 5gs4A-5f4jA:
undetectable		 5gs4A-5f4jA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 5f4j PROTRUDING DOMAIN OF
GII.17 NOROVIRUS
CAPSID
(Norwalk
virus) 		5 / 12 ASP A 446
PHE A 400
ARG A 241
PRO A 327
GLY A 325
 None
 1.42A 6gnfA-5f4jA:
undetectable		 6gnfA-5f4jA:
20.07