SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f4l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 5f4l ENVELOPE
GLYCOPROTEIN GP120
OF HIV-1 CLADE C
(Human
immunodeficiency
virus
1) 		4 / 8 PHE A 468
ILE A 359
GLY A 393
PHE A 361
 None
 0.73A 1rtsA-5f4lA:
undetectable		 1rtsA-5f4lA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 5f4l ENVELOPE
GLYCOPROTEIN GP120
OF HIV-1 CLADE C
(Human
immunodeficiency
virus
1) 		4 / 6 TYR A 217
LEU A 215
ALA A  70
THR A  71
 None
 0.83A 3b6hA-5f4lA:
undetectable		 3b6hA-5f4lA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 5f4l ENVELOPE
GLYCOPROTEIN GP120
OF HIV-1 CLADE C
(Human
immunodeficiency
virus
1) 		4 / 6 TYR A 217
LEU A 215
ALA A  70
THR A  71
 None
 0.73A 3b6hB-5f4lA:
undetectable		 3b6hB-5f4lA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 5f4l ENVELOPE
GLYCOPROTEIN GP120
OF HIV-1 CLADE C
(Human
immunodeficiency
virus
1) 		5 / 10 LEU A 259
ILE A 284
VAL A 286
GLY A 346
LEU A 452
 None
 1.00A 3ogqA-5f4lA:
undetectable		 3ogqA-5f4lA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 5f4l ENVELOPE
GLYCOPROTEIN GP120
OF HIV-1 CLADE C
(Human
immunodeficiency
virus
1) 		3 / 3 SER A 375
PHE A 382
LYS A 421
 5VE  A 501 (-2.8A)
5VE  A 501 ( 4.8A)
None
 0.78A 3u88A-5f4lA:
undetectable		 3u88A-5f4lA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5f4l ENVELOPE
GLYCOPROTEIN GP120
OF HIV-1 CLADE C
(Human
immunodeficiency
virus
1) 		5 / 12 PHE A 391
ASN A 332
VAL A 292
ILE A 449
LEU A 452
 None
 1.33A 4k39A-5f4lA:
undetectable		 4k39A-5f4lA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 5f4l ENVELOPE
GLYCOPROTEIN GP120
OF HIV-1 CLADE C
(Human
immunodeficiency
virus
1) 		5 / 9 HIS A  66
LEU A 116
VAL A 208
SER A 209
VAL A  65
 None
 1.19A 4qd3A-5f4lA:
undetectable		 4qd3A-5f4lA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 5f4l ENVELOPE
GLYCOPROTEIN GP120
OF HIV-1 CLADE C
(Human
immunodeficiency
virus
1) 		4 / 7 PHE A 468
ILE A 359
GLY A 393
PHE A 361
 None
 0.70A 5h3aB-5f4lA:
undetectable		 5h3aB-5f4lA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 5f4l ENVELOPE
GLYCOPROTEIN GP120
OF HIV-1 CLADE C
(Human
immunodeficiency
virus
1) 		3 / 3 LYS A 117
ASP A 113
ILE A 434
 None
 0.82A 5kc4E-5f4lA:
undetectable		 5kc4E-5f4lA:
16.52