SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f4o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5f4o CAPSID PROTEIN VP1
(Norwalk
virus) 		4 / 6 PHE A 242
ASN A 239
ASN A 445
GLN A 402
 None
None
None
EDO  A 602 (-3.9A)
 1.41A 1t9uA-5f4oA:
undetectable		 1t9uA-5f4oA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_B_ACTB601_0
(CHOLINE OXIDASE)		 5f4o CAPSID PROTEIN VP1
(Norwalk
virus) 		4 / 5 TRP A 457
ILE A 231
HIS A 514
VAL A 478
 None
 1.47A 3nneB-5f4oA:
undetectable		 3nneB-5f4oA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 5f4o CAPSID PROTEIN VP1
(Norwalk
virus) 		3 / 3 GLY A 346
PRO A 345
GLN A 382
 None
 0.58A 4oltB-5f4oA:
undetectable		 4oltB-5f4oA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 5f4o CAPSID PROTEIN VP1
(Norwalk
virus) 		3 / 3 GLY A 346
PRO A 345
GLN A 382
 None
 0.55A 4qwpB-5f4oA:
undetectable		 4qwpB-5f4oA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5f4o CAPSID PROTEIN VP1
(Norwalk
virus) 		4 / 9 VAL A 391
ASN A 239
ASP A 247
ILE A 449
 None
 1.00A 5lg3I-5f4oA:
undetectable		 5lg3I-5f4oA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEH_A_RPTA601_1
(SCAFFOLD PROTEIN D13)		 5f4o CAPSID PROTEIN VP1
(Norwalk
virus) 		5 / 10 GLN A 455
PRO A 406
VAL A 355
PHE A 362
PHE A 286
 None
 1.48A 6behA-5f4oA:
undetectable
6behB-5f4oA:
undetectable
6behC-5f4oA:
undetectable		 6behA-5f4oA:
19.68
6behB-5f4oA:
19.68
6behC-5f4oA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 5f4o CAPSID PROTEIN VP1
(Norwalk
virus) 		4 / 7 SER A 359
SER A 356
GLY A 329
ARG A 372
 None
 1.09A 6btxA-5f4oA:
undetectable		 6btxA-5f4oA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5f4o CAPSID PROTEIN VP1
(Norwalk
virus) 		5 / 12 ILE A 283
PHE A 327
VAL A 391
THR A 238
LEU A 237
 None
 1.10A 6djzB-5f4oA:
undetectable		 6djzB-5f4oA:
20.70