SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5f4z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		3 / 3 ALA A 259
VAL A 261
TRP A 260
 None
 0.80A 1bdwA-5f4zA:
undetectable
1bdwB-5f4zA:
undetectable		 1bdwA-5f4zA:
9.43
1bdwB-5f4zA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 LEU A 328
GLY A 177
ALA A 178
SER A 181
LEU A 182
 None
 0.93A 1cqeA-5f4zA:
undetectable		 1cqeA-5f4zA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 LEU A 328
GLY A 177
ALA A 178
SER A 181
LEU A 182
 None
 0.94A 1cqeB-5f4zA:
0.0		 1cqeB-5f4zA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 ALA A 331
ASP A 376
LEU A 377
PHE A 380
SER A 181
 None
 1.09A 1dreA-5f4zA:
undetectable		 1dreA-5f4zA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		4 / 8 SER A 102
HIS A  79
SER A 133
HIS A  97
 None
 1.19A 1eqbA-5f4zA:
undetectable
1eqbB-5f4zA:
undetectable		 1eqbA-5f4zA:
24.11
1eqbB-5f4zA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		4 / 8 SER A 102
HIS A  79
SER A 133
HIS A  97
 None
 1.19A 1eqbA-5f4zA:
undetectable
1eqbB-5f4zA:
undetectable		 1eqbA-5f4zA:
24.11
1eqbB-5f4zA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		4 / 8 SER A 102
HIS A  79
SER A 133
HIS A  97
 None
 1.19A 1eqbC-5f4zA:
undetectable
1eqbD-5f4zA:
undetectable		 1eqbC-5f4zA:
24.11
1eqbD-5f4zA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		4 / 8 SER A 102
HIS A  79
SER A 133
HIS A  97
 None
 1.20A 1eqbC-5f4zA:
undetectable
1eqbD-5f4zA:
undetectable		 1eqbC-5f4zA:
24.11
1eqbD-5f4zA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 LEU A 328
GLY A 177
ALA A 178
SER A 181
LEU A 182
 None
 0.89A 1eqhA-5f4zA:
undetectable		 1eqhA-5f4zA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 LEU A 328
GLY A 177
ALA A 178
SER A 181
LEU A 182
 None
 0.85A 1eqhB-5f4zA:
undetectable		 1eqhB-5f4zA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		4 / 7 TRP A  56
GLU A  60
ILE A   6
LEU A  13
 None
 0.96A 1q0yH-5f4zA:
undetectable
1q0yL-5f4zA:
undetectable		 1q0yH-5f4zA:
21.39
1q0yL-5f4zA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 ALA A 331
ASP A 376
LEU A 377
PHE A 380
SER A 181
 None
 0.94A 1rx3A-5f4zA:
undetectable		 1rx3A-5f4zA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		4 / 4 LEU A 311
SER A 300
ASP A 175
ASP A 336
 None
None
5V4  A 408 (-3.0A)
None
 1.38A 2br4B-5f4zA:
undetectable		 2br4B-5f4zA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 SER A 181
HIS A  97
PRO A 135
VAL A 153
ILE A 307
 None
 1.48A 2fj1A-5f4zA:
undetectable		 2fj1A-5f4zA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		4 / 8 TRP A 179
SER A 300
TRP A  99
LEU A 176
 5V4  A 408 (-3.8A)
None
None
None
 0.95A 2o01A-5f4zA:
undetectable		 2o01A-5f4zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		4 / 8 ARG A 342
SER A 185
VAL A 330
GLY A 329
 None
 1.09A 2qd3A-5f4zA:
3.2		 2qd3A-5f4zA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VKE_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 11 SER A 181
HIS A  97
PRO A 135
VAL A 153
ILE A 307
 None
 1.43A 2vkeA-5f4zA:
0.0		 2vkeA-5f4zA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		4 / 8 SER A 102
HIS A  79
SER A 133
HIS A  97
 None
 1.18A 2vmyA-5f4zA:
2.1
2vmyB-5f4zA:
2.1		 2vmyA-5f4zA:
22.97
2vmyB-5f4zA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 ALA A 331
ASP A 376
LEU A 377
PHE A 380
SER A 181
 None
 0.92A 2w3vA-5f4zA:
undetectable		 2w3vA-5f4zA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		4 / 6 PRO A 275
SER A 274
GLU A  45
TYR A  42
 None
 0.79A 2x7hA-5f4zA:
1.7		 2x7hA-5f4zA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		4 / 7 THR A 296
TYR A 291
ILE A 290
SER A 300
 None
 1.23A 2xytI-5f4zA:
undetectable		 2xytI-5f4zA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 LEU A 176
ALA A 338
GLY A 174
THR A 183
ILE A 307
 None
5V4  A 408 (-3.5A)
None
None
None
 1.04A 3c6gA-5f4zA:
undetectable		 3c6gA-5f4zA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 LEU A 367
ASP A 280
LEU A 284
SER A 102
ALA A  59
 None
None
None
None
GOL  A 404 (-3.7A)
 1.07A 3dfrA-5f4zA:
undetectable		 3dfrA-5f4zA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 SER A 181
ALA A 178
GLU A 105
GLY A  98
ASN A 198
 None
 0.95A 3f8wA-5f4zA:
2.0		 3f8wA-5f4zA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 SER A 181
ALA A 178
GLU A 105
GLY A  98
ASN A 198
 None
 0.96A 3f8wC-5f4zA:
2.2		 3f8wC-5f4zA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 LEU A 328
GLY A 177
ALA A 178
SER A 181
LEU A 182
 None
 1.05A 3ln1A-5f4zA:
undetectable		 3ln1A-5f4zA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 LEU A 328
GLY A 177
ALA A 178
SER A 181
LEU A 182
 None
 1.05A 3ln1B-5f4zA:
undetectable		 3ln1B-5f4zA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 LEU A 328
GLY A 177
ALA A 178
SER A 181
LEU A 182
 None
 1.05A 3ln1C-5f4zA:
undetectable		 3ln1C-5f4zA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 GLY A  98
VAL A 197
LEU A 182
ILE A 307
PHE A 303
 None
 1.23A 3mnoA-5f4zA:
undetectable		 3mnoA-5f4zA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 GLY A  98
VAL A 197
LEU A 182
ILE A 307
PHE A 303
 None
 1.25A 3mnpA-5f4zA:
undetectable		 3mnpA-5f4zA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 LEU A 328
GLY A 177
ALA A 178
SER A 181
LEU A 182
 None
 1.01A 3n8zA-5f4zA:
undetectable		 3n8zA-5f4zA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 LEU A 328
GLY A 177
ALA A 178
SER A 181
LEU A 182
 None
 1.06A 3nt1B-5f4zA:
undetectable		 3nt1B-5f4zA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 LEU A 328
GLY A 177
ALA A 178
SER A 181
LEU A 182
 None
 0.97A 3pghD-5f4zA:
undetectable		 3pghD-5f4zA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		4 / 6 TYR A 291
ILE A 290
SER A 299
SER A 300
 None
 0.94A 3pmzD-5f4zA:
undetectable		 3pmzD-5f4zA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 LEU A 328
GLY A 177
ALA A 178
SER A 181
LEU A 182
 None
 1.05A 3rr3A-5f4zA:
0.2		 3rr3A-5f4zA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 LEU A 328
GLY A 177
ALA A 178
SER A 181
LEU A 182
 None
 1.05A 3rr3B-5f4zA:
undetectable		 3rr3B-5f4zA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		4 / 8 ILE A  83
ILE A 131
VAL A  66
PRO A  67
 None
 0.73A 4jltA-5f4zA:
undetectable		 4jltA-5f4zA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		3 / 3 PRO A 112
LEU A 113
HIS A 196
 None
 0.70A 4pevA-5f4zA:
3.9		 4pevA-5f4zA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 10 LEU A 328
GLY A 177
ALA A 178
SER A 181
LEU A 182
 None
 0.85A 4ph9A-5f4zA:
undetectable		 4ph9A-5f4zA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 10 LEU A 328
GLY A 177
ALA A 178
SER A 181
LEU A 182
 None
 0.84A 4ph9B-5f4zA:
0.2		 4ph9B-5f4zA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		4 / 6 TYR A 169
GLY A 186
SER A 185
LEU A 184
 None
 1.25A 5bphD-5f4zA:
undetectable		 5bphD-5f4zA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 9 ASN A  77
HIS A  79
GLY A 141
GLY A 138
VAL A  78
 None
 1.37A 5f8yA-5f4zA:
undetectable		 5f8yA-5f4zA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 9 HIS A  79
GLY A 141
GLY A 138
VAL A  78
ASN A  77
 None
 1.37A 5f8yA-5f4zA:
undetectable		 5f8yA-5f4zA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 9 ASN A  77
HIS A  79
GLY A 141
GLY A 138
VAL A  78
 None
 1.37A 5f8yB-5f4zA:
undetectable		 5f8yB-5f4zA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 LEU A 328
GLY A 177
ALA A 178
SER A 181
LEU A 182
 None
 0.91A 5jvzA-5f4zA:
undetectable		 5jvzA-5f4zA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 LEU A 328
GLY A 177
ALA A 178
SER A 181
LEU A 182
 None
 0.91A 5jvzB-5f4zA:
undetectable		 5jvzB-5f4zA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 LEU A 328
GLY A 177
ALA A 178
SER A 181
LEU A 182
 None
 0.94A 5jw1A-5f4zA:
undetectable		 5jw1A-5f4zA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 12 PHE A 106
LEU A 377
LEU A 129
PHE A 127
LEU A 134
 None
 1.29A 5ljcA-5f4zA:
undetectable		 5ljcA-5f4zA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		3 / 3 GLY A 177
THR A  70
PRO A 132
 None
 0.66A 5v5zA-5f4zA:
undetectable		 5v5zA-5f4zA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EUQ_A_DXCA502_0
(MULTIDRUG
TRANSPORTER MDFA)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		5 / 11 LEU A 182
GLY A  98
PRO A 340
LEU A 328
GLN A 172
 None
 1.45A 6euqA-5f4zA:
undetectable		 6euqA-5f4zA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 5f4z EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus) 		4 / 5 ASN A 198
GLY A 194
HIS A 196
ASP A 376
 None
 0.94A 6gh9A-5f4zA:
undetectable		 6gh9A-5f4zA:
11.55